View in EDS

Aberrant myelination of the cingulum and Schneiderian delusions in schizophrenia: a 7T magnetization transfer study.

Saved in:
Bibliographic Details
Title: Aberrant myelination of the cingulum and Schneiderian delusions in schizophrenia: a 7T magnetization transfer study.
Authors: Palaniyappan, Lena, Al-Radaideh, Ali, Mougin, Olivier, Das, Tushar, Gowland, Penny, Liddle, Peter F.
Source: Psychological Medicine. Aug2019, Vol. 49 Issue 11, p1890-1896. 7p.
Subjects: Diagnosis of schizophrenia, Delusions, Limbic system, Magnetic resonance imaging, Myelination, Nerve tissue, Nervous system regeneration, Schizophrenia, Severity of illness index
Abstract: Background: The structural integrity of the anterior cingulum has been repeatedly observed to be abnormal in patients with schizophrenia. More recently, aberrant myelination of frontal fasciculi, especially, cingulum has been proposed to underlie delayed corollary discharges that can affect sense of agency and contribute to delusions of control (Schneiderian delusions). Using the magnetization transfer phenomenon at an ultra-high field 7T MRI, we investigated the putative myelin content of cingulum bundle in patients with schizophrenia. Methods: Seventeen clinically stable patients with schizophrenia and 20 controls were recruited for this 7T MRI study. We used a region-of-interest method and extracted magnetization transfer ratio (MTR) from left and right dorsal cingulum bundles and estimated patients v. controls differences. We also related the cingulum MTR values to the severity of Schneiderian delusions. Results: Patients had a significant reduction in the MTR, indicating reduced myelin content, in the cingulum bundle (right cingulum Hedges' g = 0.91; left cingulum g = 0.03). The reduced MTR of left cingulum was associated with higher severity of Schneiderian delusions (τ = −0.45, p = 0.026) but no such relationship was seen for the right cingulum MTR (τ = −0.136, p = 0.50) among patients. The association between the left cingulum MTR and Schneiderian delusions was not explained by the presence of other delusions, hallucinations, disorganization or negative symptoms. Conclusions: Dysmyelination of the cingulum bundle is seen in a subgroup of patients with schizophrenia and may be involved in the mechanism of Schneiderian delusions. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 137665105
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Aberrant myelination of the cingulum and Schneiderian delusions in schizophrenia: a 7T magnetization transfer study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Palaniyappan%2C+Lena%22">Palaniyappan, Lena</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Radaideh%2C+Ali%22">Al-Radaideh, Ali</searchLink><br /><searchLink fieldCode="AR" term="%22Mougin%2C+Olivier%22">Mougin, Olivier</searchLink><br /><searchLink fieldCode="AR" term="%22Das%2C+Tushar%22">Das, Tushar</searchLink><br /><searchLink fieldCode="AR" term="%22Gowland%2C+Penny%22">Gowland, Penny</searchLink><br /><searchLink fieldCode="AR" term="%22Liddle%2C+Peter+F%2E%22">Liddle, Peter F.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Aug2019, Vol. 49 Issue 11, p1890-1896. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Diagnosis+of+schizophrenia%22">Diagnosis of schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Delusions%22">Delusions</searchLink><br /><searchLink fieldCode="DE" term="%22Limbic+system%22">Limbic system</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Myelination%22">Myelination</searchLink><br /><searchLink fieldCode="DE" term="%22Nerve+tissue%22">Nerve tissue</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system+regeneration%22">Nervous system regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: The structural integrity of the anterior cingulum has been repeatedly observed to be abnormal in patients with schizophrenia. More recently, aberrant myelination of frontal fasciculi, especially, cingulum has been proposed to underlie delayed corollary discharges that can affect sense of agency and contribute to delusions of control (Schneiderian delusions). Using the magnetization transfer phenomenon at an ultra-high field 7T MRI, we investigated the putative myelin content of cingulum bundle in patients with schizophrenia. Methods: Seventeen clinically stable patients with schizophrenia and 20 controls were recruited for this 7T MRI study. We used a region-of-interest method and extracted magnetization transfer ratio (MTR) from left and right dorsal cingulum bundles and estimated patients v. controls differences. We also related the cingulum MTR values to the severity of Schneiderian delusions. Results: Patients had a significant reduction in the MTR, indicating reduced myelin content, in the cingulum bundle (right cingulum Hedges' g = 0.91; left cingulum g = 0.03). The reduced MTR of left cingulum was associated with higher severity of Schneiderian delusions (τ = −0.45, p = 0.026) but no such relationship was seen for the right cingulum MTR (τ = −0.136, p = 0.50) among patients. The association between the left cingulum MTR and Schneiderian delusions was not explained by the presence of other delusions, hallucinations, disorganization or negative symptoms. Conclusions: Dysmyelination of the cingulum bundle is seen in a subgroup of patients with schizophrenia and may be involved in the mechanism of Schneiderian delusions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=137665105
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1017/S0033291718002647
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 1890
    Subjects:
      – SubjectFull: Diagnosis of schizophrenia
        Type: general
      – SubjectFull: Delusions
        Type: general
      – SubjectFull: Limbic system
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Myelination
        Type: general
      – SubjectFull: Nerve tissue
        Type: general
      – SubjectFull: Nervous system regeneration
        Type: general
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
    Titles:
      – TitleFull: Aberrant myelination of the cingulum and Schneiderian delusions in schizophrenia: a 7T magnetization transfer study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Palaniyappan, Lena
      – PersonEntity:
          Name:
            NameFull: Al-Radaideh, Ali
      – PersonEntity:
          Name:
            NameFull: Mougin, Olivier
      – PersonEntity:
          Name:
            NameFull: Das, Tushar
      – PersonEntity:
          Name:
            NameFull: Gowland, Penny
      – PersonEntity:
          Name:
            NameFull: Liddle, Peter F.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2019
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 00332917
          Numbering:
            – Type: volume
              Value: 49
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Psychological Medicine
              Type: main
ResultId 1