Status of inflammation in relation to health related quality of life in hepatocellular carcinoma patients.
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| Title: | Status of inflammation in relation to health related quality of life in hepatocellular carcinoma patients. |
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| Authors: | Li, Leung (AUTHOR), Chan, Stephen L. (AUTHOR), Mo, Frankie (AUTHOR), Hui, Edwin P. (AUTHOR), Koh, Jane (AUTHOR), Chan, Allen KC (AUTHOR), Tang, Nelson LS (AUTHOR), Chu, Cheuk M. (AUTHOR), Hui, Joyce (AUTHOR), Lee, Kit F. (AUTHOR), Yu, Simon (AUTHOR), Yeo, Winnie (AUTHOR) |
| Source: | Quality of Life Research. Sep2019, Vol. 28 Issue 9, p2597-2607. 11p. 1 Diagram, 8 Charts. |
| Subjects: | Hepatocellular carcinoma, Appetite loss, Pearson correlation (Statistics), Body image, Quality of life |
| Abstract: | |
| Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| FullText | Links: – Type: pdflink Text: Availability: 1 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 138126818 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Status of inflammation in relation to health related quality of life in hepatocellular carcinoma patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li%2C+Leung%22">Li, Leung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Stephen+L%2E%22">Chan, Stephen L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mo%2C+Frankie%22">Mo, Frankie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hui%2C+Edwin+P%2E%22">Hui, Edwin P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koh%2C+Jane%22">Koh, Jane</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Allen+KC%22">Chan, Allen KC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Nelson+LS%22">Tang, Nelson LS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chu%2C+Cheuk+M%2E%22">Chu, Cheuk M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hui%2C+Joyce%22">Hui, Joyce</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Kit+F%2E%22">Lee, Kit F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Simon%22">Yu, Simon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yeo%2C+Winnie%22">Yeo, Winnie</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Sep2019, Vol. 28 Issue 9, p2597-2607. 11p. 1 Diagram, 8 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hepatocellular+carcinoma%22">Hepatocellular carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Appetite+loss%22">Appetite loss</searchLink><br /><searchLink fieldCode="DE" term="%22Pearson+correlation+%28Statistics%29%22">Pearson correlation (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Body+image%22">Body image</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: <bold>Purpose: </bold>Both Inflammation and health-related quality of life (HRQoL) are independent prognosticators in HCC patients. We hypothesized that inflammation can cause impairment in HRQoL and investigated the correlation between inflammatory status and HRQoL in HCC patients.<bold>Methods: </bold>Clinical, laboratory and HRQoL (using EORTC QLQ-C30, QLQ-HCC18, C30 and HCC18 index-scores) data were prospectively collected from HCC patients at diagnosis. Correlation analyses were performed between HRQoL and inflammation-based markers including C-reactive protein (CRP), CRP/albumin ratio (CRP/alb), Glasgow Prognostic Score (GPS), Inflammation-Based Index (IBI) and Prognostic Index (PI).<bold>Results: </bold>Among 445 HCC patients, higher inflammatory states were significantly correlated with worse HRQoL. For CRP and CRP/alb ratio, the HRQoL factors with higher correlations included C30 and HCC18 index-scores, certain QLQ-C30 domains and items ('physical functioning', 'role functioning', 'fatigue', 'pain', 'appetite loss') and QLQ-HCC18 items ('fatigue', 'body image', 'nutrition' and 'abdominal swelling'), where the Pearson's correlation coefficients were up to 0.416. Multivariate analyses indicated that worse HRQoL factors were significantly correlated with worse scores in GPS, IBI and PI.<bold>Conclusion: </bold>In HCC patients, inflammatory status correlates with HRQoL at presentation. In particular, relatively stronger correlations with CRP-based markers have been observed in HRQoL scales that assess constitutional symptoms (QLQ-C30 'physical functioning', 'role functioning', 'fatigue', 'appetite loss' and QLQ-HCC18 'fatigue' and 'nutrition') and tumor burden (QLQ-C30 'pain' and QLQ-HCC18 'abdominal swelling' and 'body image'). Future studies are warranted to evaluate whether intervention that reduces inflammation could improve HRQoL in HCC patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=138126818 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11136-019-02190-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 2597 Subjects: – SubjectFull: Hepatocellular carcinoma Type: general – SubjectFull: Appetite loss Type: general – SubjectFull: Pearson correlation (Statistics) Type: general – SubjectFull: Body image Type: general – SubjectFull: Quality of life Type: general Titles: – TitleFull: Status of inflammation in relation to health related quality of life in hepatocellular carcinoma patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Leung – PersonEntity: Name: NameFull: Chan, Stephen L. – PersonEntity: Name: NameFull: Mo, Frankie – PersonEntity: Name: NameFull: Hui, Edwin P. – PersonEntity: Name: NameFull: Koh, Jane – PersonEntity: Name: NameFull: Chan, Allen KC – PersonEntity: Name: NameFull: Tang, Nelson LS – PersonEntity: Name: NameFull: Chu, Cheuk M. – PersonEntity: Name: NameFull: Hui, Joyce – PersonEntity: Name: NameFull: Lee, Kit F. – PersonEntity: Name: NameFull: Yu, Simon – PersonEntity: Name: NameFull: Yeo, Winnie IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 09629343 Numbering: – Type: volume Value: 28 – Type: issue Value: 9 Titles: – TitleFull: Quality of Life Research Type: main |
| ResultId | 1 |
