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Existing and emerging applications for the neuromodulation of nerve activity through targeted delivery of electric stimuli.

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Title: Existing and emerging applications for the neuromodulation of nerve activity through targeted delivery of electric stimuli.
Authors: Ginn, Claire (AUTHOR), Patel, Bipin (AUTHOR), Walker, Robert (AUTHOR)
Source: International Journal of Neuroscience. Oct2019, Vol. 129 Issue 10, p1013-1023. 11p.
Subjects: Autonomic nervous system, Nerves, Vagus nerve, Sacral nerves, Parkinson's disease, Neuromodulation
Abstract: The effective treatment of many diseases requires the use of multiple treatment strategies among which neuromodulation is playing an increasingly important role. Neuromodulation devices that act to normalize or modulate nerve activity through the targeted delivery of electrical stimuli will be the focus of this review. These devices encompass deep brain stimulators, vagus nerve stimulators, spinal cord simulators and sacral nerve stimulators. Already neuromodulation has proven successful in the treatment of a broad range of conditions from Parkinson's disease to chronic pain and urinary incontinence. Many of these approaches seek to exploit the activities of the autonomic nervous system, which influences organ function through the release of neurotransmitters and associated signalling cascades. This review will outline existing and emerging applications for each of these neuromodulation devices, proposed mechanisms of action and clinical studies evaluating both their safety and therapeutic efficacy. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Existing and emerging applications for the neuromodulation of nerve activity through targeted delivery of electric stimuli.
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  Data: <searchLink fieldCode="AR" term="%22Ginn%2C+Claire%22">Ginn, Claire</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patel%2C+Bipin%22">Patel, Bipin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Walker%2C+Robert%22">Walker, Robert</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Oct2019, Vol. 129 Issue 10, p1013-1023. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Autonomic+nervous+system%22">Autonomic nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Nerves%22">Nerves</searchLink><br /><searchLink fieldCode="DE" term="%22Vagus+nerve%22">Vagus nerve</searchLink><br /><searchLink fieldCode="DE" term="%22Sacral+nerves%22">Sacral nerves</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Neuromodulation%22">Neuromodulation</searchLink>
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  Label: Abstract
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  Data: The effective treatment of many diseases requires the use of multiple treatment strategies among which neuromodulation is playing an increasingly important role. Neuromodulation devices that act to normalize or modulate nerve activity through the targeted delivery of electrical stimuli will be the focus of this review. These devices encompass deep brain stimulators, vagus nerve stimulators, spinal cord simulators and sacral nerve stimulators. Already neuromodulation has proven successful in the treatment of a broad range of conditions from Parkinson's disease to chronic pain and urinary incontinence. Many of these approaches seek to exploit the activities of the autonomic nervous system, which influences organ function through the release of neurotransmitters and associated signalling cascades. This review will outline existing and emerging applications for each of these neuromodulation devices, proposed mechanisms of action and clinical studies evaluating both their safety and therapeutic efficacy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1080/00207454.2019.1609473
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      – Code: eng
        Text: English
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        PageCount: 11
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    Subjects:
      – SubjectFull: Autonomic nervous system
        Type: general
      – SubjectFull: Nerves
        Type: general
      – SubjectFull: Vagus nerve
        Type: general
      – SubjectFull: Sacral nerves
        Type: general
      – SubjectFull: Parkinson's disease
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      – SubjectFull: Neuromodulation
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      – TitleFull: Existing and emerging applications for the neuromodulation of nerve activity through targeted delivery of electric stimuli.
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              Text: Oct2019
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              Y: 2019
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