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Effects of OSA Surgery on Ophthalmological Microstructures.

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Title: Effects of OSA Surgery on Ophthalmological Microstructures.
Authors: Lin, Pei-Wen, Lin, Hsin-Ching, Friedman, Michael, Chang, Hsueh-Wen, Salapatas, Anna M., Lin, Meng-Chih, Chin, Chien-Hung
Source: Annals of Otology, Rhinology & Laryngology. Oct2019, Vol. 128 Issue 10, p938-948. 11p.
Subjects: Retinal anatomy, Academic medical centers, Reactive oxygen species, Eye examination, Longitudinal method, Operative otolaryngology, Oxygen in the body, Perimetry, Sleep apnea syndromes, Visual acuity, Visual perception, Polysomnography, Optical coherence tomography, Blind experiment, Descriptive statistics
Abstract: Objective: Obstructive sleep apnea/hypopnea syndrome (OSA) could compromise oxygenation of the optic nerve and cause glaucomatous optic neuropathy; however, there were no studies to investigate the changes of visual function and retinal microstructures in OSA patients after upper airway surgery. We aim to assess the changes in the visual sensitivity and retinal fiber layer thickness in OSA patients before and after surgery. Methods: This prospective single-blind study enrolled patients with OSA from a tertiary academic medical center who had unsuccessful conservative therapy and then underwent surgery. The patients were referred for comprehensive ophthalmologic evaluation at baseline and 6 months after OSA surgery. The polysomnographic findings were collected pre- and postoperatively. Visual sensitivities on standard automated perimetry (SAP) were assessed. Peripapillary retinal nerve fiber layer (RNFL) thickness and macular layer (ML) thickness parameters were measured by spectral-domain optical coherence tomography (OCT). Results: A total of 108 OSA patients were enrolled. Six months after surgery, the major parameters of polysomnography (PSG), mean deviation, and pattern standard deviation of SAP significantly improved in these OSA patients. Regarding the OCT parameters, thickness of ML in the nasal-outer, superior-inner, temporal-inner, inferior-inner, nasal-inner sectors, and total ML thickness significantly increased 6 months after upper airway surgery in the severe OSA group (apnea/hypopnea index ⩾30 per hour). Conclusion: The visual sensitivities on SAP, ML thickness on OCT, and oxygenation status on PSG significantly improved 6 months after upper airway surgery in patients with severe OSA. Upper airway surgery may ameliorate the microstructures of the retina in patients with severe OSA. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of OSA Surgery on Ophthalmological Microstructures.
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  Data: <searchLink fieldCode="AR" term="%22Lin%2C+Pei-Wen%22">Lin, Pei-Wen</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Hsin-Ching%22">Lin, Hsin-Ching</searchLink><br /><searchLink fieldCode="AR" term="%22Friedman%2C+Michael%22">Friedman, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Chang%2C+Hsueh-Wen%22">Chang, Hsueh-Wen</searchLink><br /><searchLink fieldCode="AR" term="%22Salapatas%2C+Anna+M%2E%22">Salapatas, Anna M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Meng-Chih%22">Lin, Meng-Chih</searchLink><br /><searchLink fieldCode="AR" term="%22Chin%2C+Chien-Hung%22">Chin, Chien-Hung</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22">Annals of Otology, Rhinology & Laryngology</searchLink>. Oct2019, Vol. 128 Issue 10, p938-948. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Retinal+anatomy%22">Retinal anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Eye+examination%22">Eye examination</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Operative+otolaryngology%22">Operative otolaryngology</searchLink><br /><searchLink fieldCode="DE" term="%22Oxygen+in+the+body%22">Oxygen in the body</searchLink><br /><searchLink fieldCode="DE" term="%22Perimetry%22">Perimetry</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+apnea+syndromes%22">Sleep apnea syndromes</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+acuity%22">Visual acuity</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+perception%22">Visual perception</searchLink><br /><searchLink fieldCode="DE" term="%22Polysomnography%22">Polysomnography</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+coherence+tomography%22">Optical coherence tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Blind+experiment%22">Blind experiment</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Obstructive sleep apnea/hypopnea syndrome (OSA) could compromise oxygenation of the optic nerve and cause glaucomatous optic neuropathy; however, there were no studies to investigate the changes of visual function and retinal microstructures in OSA patients after upper airway surgery. We aim to assess the changes in the visual sensitivity and retinal fiber layer thickness in OSA patients before and after surgery. Methods: This prospective single-blind study enrolled patients with OSA from a tertiary academic medical center who had unsuccessful conservative therapy and then underwent surgery. The patients were referred for comprehensive ophthalmologic evaluation at baseline and 6 months after OSA surgery. The polysomnographic findings were collected pre- and postoperatively. Visual sensitivities on standard automated perimetry (SAP) were assessed. Peripapillary retinal nerve fiber layer (RNFL) thickness and macular layer (ML) thickness parameters were measured by spectral-domain optical coherence tomography (OCT). Results: A total of 108 OSA patients were enrolled. Six months after surgery, the major parameters of polysomnography (PSG), mean deviation, and pattern standard deviation of SAP significantly improved in these OSA patients. Regarding the OCT parameters, thickness of ML in the nasal-outer, superior-inner, temporal-inner, inferior-inner, nasal-inner sectors, and total ML thickness significantly increased 6 months after upper airway surgery in the severe OSA group (apnea/hypopnea index ⩾30 per hour). Conclusion: The visual sensitivities on SAP, ML thickness on OCT, and oxygenation status on PSG significantly improved 6 months after upper airway surgery in patients with severe OSA. Upper airway surgery may ameliorate the microstructures of the retina in patients with severe OSA. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1177/0003489419849082
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 938
    Subjects:
      – SubjectFull: Retinal anatomy
        Type: general
      – SubjectFull: Academic medical centers
        Type: general
      – SubjectFull: Reactive oxygen species
        Type: general
      – SubjectFull: Eye examination
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Operative otolaryngology
        Type: general
      – SubjectFull: Oxygen in the body
        Type: general
      – SubjectFull: Perimetry
        Type: general
      – SubjectFull: Sleep apnea syndromes
        Type: general
      – SubjectFull: Visual acuity
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      – SubjectFull: Visual perception
        Type: general
      – SubjectFull: Polysomnography
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      – SubjectFull: Optical coherence tomography
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      – SubjectFull: Blind experiment
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      – SubjectFull: Descriptive statistics
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      – TitleFull: Effects of OSA Surgery on Ophthalmological Microstructures.
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            NameFull: Lin, Pei-Wen
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              Text: Oct2019
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              Y: 2019
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