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The PRIAMO study: active sexual life is associated with better motor and non‐motor outcomes in men with early Parkinson's disease.

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Title: The PRIAMO study: active sexual life is associated with better motor and non‐motor outcomes in men with early Parkinson's disease.
Authors: Picillo, M. (AUTHOR), Palladino, R. (AUTHOR), Erro, R. (AUTHOR), Colosimo, C. (AUTHOR), Marconi, R. (AUTHOR), Antonini, A. (AUTHOR), Barone, P. (AUTHOR)
Source: European Journal of Neurology. Oct2019, Vol. 26 Issue 10, p1327-1333. 7p. 2 Charts, 1 Graph.
Subjects: Parkinson's disease, Fossil hominids, Impotence, Apathy, Sexual intercourse, Movement disorders, Neurorehabilitation, Sexual dysfunction, Logistic regression analysis
Abstract: Background and purpose: Data suggest a relationship between sexual dysfunction, mainly erectile dysfunction in men, and worse disease progression in Parkinson's disease (PD). There is scant evidence on the correlates of sexual activity in PD patients. By involving a subgroup of 355 patients from the PRIAMO (Parkinson Disease Non Motor Symptoms) study, the present 24‐month longitudinal prospective analysis aims to demonstrate that the presence of active sexual life is associated with disease progression in early PD. Methods and results: Multivariable mixed‐effect logistic regression models showed that gastrointestinal symptoms [odds ratio 0.56, 95% confidence interval (CI) 0.39–0.82, P = 0.003] and apathy (odds ratio 0.42, 95% CI 0.29–0.63, P < 0.001) were less likely to be associated with sexual activity in men. Analysis also demonstrated that sexual activity in men was associated with lower motor disability (coefficient −2.881, 95% CI −4.732 to −1.030, P = 0.002), better quality of life (coefficient −24.196, 95% CI −44.884 to −3.508, P = 0.022; coefficient 0.083, 95% CI 0.023–0.143, P = 0.006) and lower depression scores (coefficient −1.245, 95% CI −2.104 to −0.387, P = 0.004). No association was shown in women. Conclusions: This is the first prospective longitudinal study involving a large cohort of PD patients suggesting that sexual activity is associated with lower motor and non‐motor disability as well as with better quality of life in men. These findings should prompt movement disorders specialists to periodically inquiry about their patients' sexual life. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The PRIAMO study: active sexual life is associated with better motor and non‐motor outcomes in men with early Parkinson&#39;s disease.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Picillo%2C+M%2E%22&quot;&gt;Picillo, M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Palladino%2C+R%2E%22&quot;&gt;Palladino, R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Erro%2C+R%2E%22&quot;&gt;Erro, R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Colosimo%2C+C%2E%22&quot;&gt;Colosimo, C.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Marconi%2C+R%2E%22&quot;&gt;Marconi, R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Antonini%2C+A%2E%22&quot;&gt;Antonini, A.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Barone%2C+P%2E%22&quot;&gt;Barone, P.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Oct2019, Vol. 26 Issue 10, p1327-1333. 7p. 2 Charts, 1 Graph.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Parkinson&#39;s+disease%22&quot;&gt;Parkinson&#39;s disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fossil+hominids%22&quot;&gt;Fossil hominids&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Impotence%22&quot;&gt;Impotence&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Apathy%22&quot;&gt;Apathy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sexual+intercourse%22&quot;&gt;Sexual intercourse&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Movement+disorders%22&quot;&gt;Movement disorders&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neurorehabilitation%22&quot;&gt;Neurorehabilitation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sexual+dysfunction%22&quot;&gt;Sexual dysfunction&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Logistic+regression+analysis%22&quot;&gt;Logistic regression analysis&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose: Data suggest a relationship between sexual dysfunction, mainly erectile dysfunction in men, and worse disease progression in Parkinson&#39;s disease (PD). There is scant evidence on the correlates of sexual activity in PD patients. By involving a subgroup of 355 patients from the PRIAMO (Parkinson Disease Non Motor Symptoms) study, the present 24‐month longitudinal prospective analysis aims to demonstrate that the presence of active sexual life is associated with disease progression in early PD. Methods and results: Multivariable mixed‐effect logistic regression models showed that gastrointestinal symptoms [odds ratio 0.56, 95% confidence interval (CI) 0.39–0.82, P&#160;=&#160;0.003] and apathy (odds ratio 0.42, 95% CI 0.29–0.63, P&#160;&lt;&#160;0.001) were less likely to be associated with sexual activity in men. Analysis also demonstrated that sexual activity in men was associated with lower motor disability (coefficient −2.881, 95% CI −4.732 to −1.030, P&#160;=&#160;0.002), better quality of life (coefficient −24.196, 95% CI −44.884 to −3.508, P&#160;=&#160;0.022; coefficient 0.083, 95% CI 0.023–0.143, P&#160;=&#160;0.006) and lower depression scores (coefficient −1.245, 95% CI −2.104 to −0.387, P&#160;=&#160;0.004). No association was shown in women. Conclusions: This is the first prospective longitudinal study involving a large cohort of PD patients suggesting that sexual activity is associated with lower motor and non‐motor disability as well as with better quality of life in men. These findings should prompt movement disorders specialists to periodically inquiry about their patients&#39; sexual life. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1111/ene.13983
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 1327
    Subjects:
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Fossil hominids
        Type: general
      – SubjectFull: Impotence
        Type: general
      – SubjectFull: Apathy
        Type: general
      – SubjectFull: Sexual intercourse
        Type: general
      – SubjectFull: Movement disorders
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      – SubjectFull: Neurorehabilitation
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      – SubjectFull: Sexual dysfunction
        Type: general
      – SubjectFull: Logistic regression analysis
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      – TitleFull: The PRIAMO study: active sexual life is associated with better motor and non‐motor outcomes in men with early Parkinson's disease.
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              Text: Oct2019
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              Y: 2019
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