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Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function.

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Title: Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function.
Authors: Goldberg, Lisa R. (AUTHOR), Gould, Thomas J. (AUTHOR)
Source: European Journal of Neuroscience. Aug2019, Vol. 50 Issue 3, p2453-2466. 14p. 4 Charts.
Subjects: Drugs of abuse, Drug addiction, Pharmacology, Child abuse, Nicotine, Addictions
Abstract: Addictions are highly heritable disorders, with heritability estimates ranging from 39% to 72%. Multiple studies suggest a link between paternal drug abuse and addiction in their children. However, patterns of inheritance cannot be explained purely by Mendelian genetic mechanisms. Exposure to drugs of abuse results in epigenetic changes that may be passed on through the germline. This mechanism of epigenetic transgenerational inheritance may provide a link between paternal drug exposure and addiction susceptibility in the offspring. Recent studies have begun to investigate the effect of paternal drug exposure on behavioral and neurobiological phenotypes in offspring of drug‐exposed fathers in rodent models. This review aims to discuss behavioral and neural effects of paternal exposure to alcohol, cocaine, opioids, and nicotine. Although a special focus will be on addiction‐relevant behaviors, additional behavioral effects including cognition, anxiety, and depressive‐like behaviors will be discussed. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function.
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  Data: <searchLink fieldCode="AR" term="%22Goldberg%2C+Lisa+R%2E%22">Goldberg, Lisa R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gould%2C+Thomas+J%2E%22">Gould, Thomas J.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Aug2019, Vol. 50 Issue 3, p2453-2466. 14p. 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Drugs+of+abuse%22">Drugs of abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+addiction%22">Drug addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacology%22">Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Child+abuse%22">Child abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Nicotine%22">Nicotine</searchLink><br /><searchLink fieldCode="DE" term="%22Addictions%22">Addictions</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Addictions are highly heritable disorders, with heritability estimates ranging from 39% to 72%. Multiple studies suggest a link between paternal drug abuse and addiction in their children. However, patterns of inheritance cannot be explained purely by Mendelian genetic mechanisms. Exposure to drugs of abuse results in epigenetic changes that may be passed on through the germline. This mechanism of epigenetic transgenerational inheritance may provide a link between paternal drug exposure and addiction susceptibility in the offspring. Recent studies have begun to investigate the effect of paternal drug exposure on behavioral and neurobiological phenotypes in offspring of drug‐exposed fathers in rodent models. This review aims to discuss behavioral and neural effects of paternal exposure to alcohol, cocaine, opioids, and nicotine. Although a special focus will be on addiction‐relevant behaviors, additional behavioral effects including cognition, anxiety, and depressive‐like behaviors will be discussed. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=138540385
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        Value: 10.1111/ejn.14060
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      – Code: eng
        Text: English
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        PageCount: 14
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    Subjects:
      – SubjectFull: Drugs of abuse
        Type: general
      – SubjectFull: Drug addiction
        Type: general
      – SubjectFull: Pharmacology
        Type: general
      – SubjectFull: Child abuse
        Type: general
      – SubjectFull: Nicotine
        Type: general
      – SubjectFull: Addictions
        Type: general
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      – TitleFull: Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function.
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              Text: Aug2019
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              Y: 2019
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              Value: 50
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