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Interferon-γ Expression in the Inner Ear of Rats Following Secondary Immune Reaction in the Endolymphatic Sac.

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Title: Interferon-γ Expression in the Inner Ear of Rats Following Secondary Immune Reaction in the Endolymphatic Sac.
Authors: Pawankar, Ruby, Tomiyama, Shunichi, Ikezono, Tetsuo, Nonaka, Manabu, Jinnouchi, Ken, Yagi, Toshiaki
Source: Acta Oto-Laryngologica (Supplement). Aug2004 Supplement 553, Vol. 124, p6-12. 7p. 1 Color Photograph, 1 Chart, 4 Graphs.
Subjects: Inner ear, Interferons, Rats, Antigens, Cytokines
Abstract: Recently, we demonstrated increased intercellular adhesion molecule-1 (ICAM-1) expression in the inner ear of systemically pre-sensitized rats after antigen [keyhole limpet hemocyanin (KLH)] challenge into the endolymphatic sac (ES), in good correlation with the cellular infiltration. Interferon-γ (IFN-γ) is an important cytokine that upregulates the expression of ICAM-1. Here, we report upregulation of IFN-γ expression in the inner ear of systemically pre-sensitized rats after antigen (KLH) challenge into the ES. Immunoreactivity for IFN-γ was detected in the spiral ligament, suprastrial region, spiral modiolar veins, spiral collecting venules, surface membrane of the perilymphatic compartment and perilymphatic space of immunized, but not control, rats. IFN-γ expression was detected at 1.5 h post-challenge, peaked at 6 h and gradually returned to baseline levels after 7 days. Interestingly, the time kinetics of IFN-γ expression were in good correlation with those of ICAM-1. These observations demonstrate that antigen challenge into the ES induces IFN-γ expression, which can then upregulate ICAM-1 expression and induce cell infiltration, suggesting that IFN-γ may play a crucial role in immune-mediated inner ear diseases. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Interferon-γ Expression in the Inner Ear of Rats Following Secondary Immune Reaction in the Endolymphatic Sac.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica+%28Supplement%29%22">Acta Oto-Laryngologica (Supplement)</searchLink>. Aug2004 Supplement 553, Vol. 124, p6-12. 7p. 1 Color Photograph, 1 Chart, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Inner+ear%22">Inner ear</searchLink><br /><searchLink fieldCode="DE" term="%22Interferons%22">Interferons</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Antigens%22">Antigens</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Recently, we demonstrated increased intercellular adhesion molecule-1 (ICAM-1) expression in the inner ear of systemically pre-sensitized rats after antigen [keyhole limpet hemocyanin (KLH)] challenge into the endolymphatic sac (ES), in good correlation with the cellular infiltration. Interferon-γ (IFN-γ) is an important cytokine that upregulates the expression of ICAM-1. Here, we report upregulation of IFN-γ expression in the inner ear of systemically pre-sensitized rats after antigen (KLH) challenge into the ES. Immunoreactivity for IFN-γ was detected in the spiral ligament, suprastrial region, spiral modiolar veins, spiral collecting venules, surface membrane of the perilymphatic compartment and perilymphatic space of immunized, but not control, rats. IFN-γ expression was detected at 1.5 h post-challenge, peaked at 6 h and gradually returned to baseline levels after 7 days. Interestingly, the time kinetics of IFN-γ expression were in good correlation with those of ICAM-1. These observations demonstrate that antigen challenge into the ES induces IFN-γ expression, which can then upregulate ICAM-1 expression and induce cell infiltration, suggesting that IFN-γ may play a crucial role in immune-mediated inner ear diseases. [ABSTRACT FROM AUTHOR]
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  Label:
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  Data: <i>Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Aug2004 Supplement 553
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