Interferon-γ Expression in the Inner Ear of Rats Following Secondary Immune Reaction in the Endolymphatic Sac.
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| Title: | Interferon-γ Expression in the Inner Ear of Rats Following Secondary Immune Reaction in the Endolymphatic Sac. |
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| Authors: | Pawankar, Ruby, Tomiyama, Shunichi, Ikezono, Tetsuo, Nonaka, Manabu, Jinnouchi, Ken, Yagi, Toshiaki |
| Source: | Acta Oto-Laryngologica (Supplement). Aug2004 Supplement 553, Vol. 124, p6-12. 7p. 1 Color Photograph, 1 Chart, 4 Graphs. |
| Subjects: | Inner ear, Interferons, Rats, Antigens, Cytokines |
| Abstract: | Recently, we demonstrated increased intercellular adhesion molecule-1 (ICAM-1) expression in the inner ear of systemically pre-sensitized rats after antigen [keyhole limpet hemocyanin (KLH)] challenge into the endolymphatic sac (ES), in good correlation with the cellular infiltration. Interferon-γ (IFN-γ) is an important cytokine that upregulates the expression of ICAM-1. Here, we report upregulation of IFN-γ expression in the inner ear of systemically pre-sensitized rats after antigen (KLH) challenge into the ES. Immunoreactivity for IFN-γ was detected in the spiral ligament, suprastrial region, spiral modiolar veins, spiral collecting venules, surface membrane of the perilymphatic compartment and perilymphatic space of immunized, but not control, rats. IFN-γ expression was detected at 1.5 h post-challenge, peaked at 6 h and gradually returned to baseline levels after 7 days. Interestingly, the time kinetics of IFN-γ expression were in good correlation with those of ICAM-1. These observations demonstrate that antigen challenge into the ES induces IFN-γ expression, which can then upregulate ICAM-1 expression and induce cell infiltration, suggesting that IFN-γ may play a crucial role in immune-mediated inner ear diseases. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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