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Food craving and consumption evolution in patients starting treatment with clozapine.

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Title: Food craving and consumption evolution in patients starting treatment with clozapine.
Authors: Garriga, Marina (AUTHOR), Mallorquí, Andrea (AUTHOR), Serrano, Lourdes (AUTHOR), Ríos, José (AUTHOR), Salamero, Manel (AUTHOR), Parellada, Eduard (AUTHOR), Gómez-Ramiro, Marta (AUTHOR), Oliveira, Cristina (AUTHOR), Amoretti, Silvia (AUTHOR), Vieta, Eduard (AUTHOR), Bernardo, Miquel (AUTHOR), García-Rizo, Clemente (AUTHOR)
Source: Psychopharmacology. Nov2019, Vol. 236 Issue 11, p3317-3327. 11p. 3 Charts, 1 Graph.
Subjects: Food consumption, Food preferences, Body mass index, Generalized estimating equations, Body weight, Convenience foods, Aripiprazole, Herbicide resistance
Abstract: Background: Antipsychotic-induced weight gain has been especially related to clozapine and olanzapine. Underlying mechanisms in relation to food preferences with an increased food craving and consumption of specific nutrients have not been extensively studied in patients with serious mental illness (SMI). We aim to describe specific food preferences (craving) and subsequent food consumption in SMI patients starting clozapine, as well as their possible relation to weight and body mass index (BMI). Methods: An observational prospective follow-up study (18 weeks) was conducted in a cohort of 34 SMI patients who started clozapine due to resistant-psychotic symptoms. Anthropometric measures, Food Craving Inventory (FCI), and a food consumption frequency questionnaire were evaluated at baseline, weeks 8 and 18 of treatment. Statistical analysis included generalized estimating equations models with adjustment for potential confounding factors. Results: No longitudinal changes over time were found across the different food craving scores after 18 weeks of treatment. However, adjusted models according to BMI status showed that the normal weight (NW) group presented an increased score for the "complex carbohydrates/proteins" food cravings (− 0.67; 95% CI [− 1.15, − 0.19]; P = 0.010), while baseline scores for "fast-food fats" cravings were significantly higher in the overweight/obese (OWO) group in comparison with NW patients (NW, 2.05; 95% CI [1.60, 2.49]; OWO, 2.81, 95% CI [2.37, 3.25]; P = 0.016). When considering if food craving could predict weight gain, only increments in "fast-food fats" cravings were associated (β = − 5.35 ± 1.67; 95% CI [− 8.64, − 2.06]; P = 0.001). Conclusions: No longitudinal differences were found for any of the food craving scores evaluated; however, in the NW group, food craving for "complex carbohydrates/proteins" changed. Thus, changes in "fast-food fats" cravings predicted weight increase in this sample. Interventions targeting food preferences may help to mitigate weight gain in patients starting treatment with clozapine. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Food craving and consumption evolution in patients starting treatment with clozapine.
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  Data: <searchLink fieldCode="AR" term="%22Garriga%2C+Marina%22">Garriga, Marina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mallorquí%2C+Andrea%22">Mallorquí, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Serrano%2C+Lourdes%22">Serrano, Lourdes</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ríos%2C+José%22">Ríos, José</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salamero%2C+Manel%22">Salamero, Manel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Parellada%2C+Eduard%22">Parellada, Eduard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gómez-Ramiro%2C+Marta%22">Gómez-Ramiro, Marta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oliveira%2C+Cristina%22">Oliveira, Cristina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amoretti%2C+Silvia%22">Amoretti, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vieta%2C+Eduard%22">Vieta, Eduard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bernardo%2C+Miquel%22">Bernardo, Miquel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22García-Rizo%2C+Clemente%22">García-Rizo, Clemente</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Nov2019, Vol. 236 Issue 11, p3317-3327. 11p. 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Food+consumption%22">Food consumption</searchLink><br /><searchLink fieldCode="DE" term="%22Food+preferences%22">Food preferences</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink><br /><searchLink fieldCode="DE" term="%22Generalized+estimating+equations%22">Generalized estimating equations</searchLink><br /><searchLink fieldCode="DE" term="%22Body+weight%22">Body weight</searchLink><br /><searchLink fieldCode="DE" term="%22Convenience+foods%22">Convenience foods</searchLink><br /><searchLink fieldCode="DE" term="%22Aripiprazole%22">Aripiprazole</searchLink><br /><searchLink fieldCode="DE" term="%22Herbicide+resistance%22">Herbicide resistance</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Antipsychotic-induced weight gain has been especially related to clozapine and olanzapine. Underlying mechanisms in relation to food preferences with an increased food craving and consumption of specific nutrients have not been extensively studied in patients with serious mental illness (SMI). We aim to describe specific food preferences (craving) and subsequent food consumption in SMI patients starting clozapine, as well as their possible relation to weight and body mass index (BMI). Methods: An observational prospective follow-up study (18 weeks) was conducted in a cohort of 34 SMI patients who started clozapine due to resistant-psychotic symptoms. Anthropometric measures, Food Craving Inventory (FCI), and a food consumption frequency questionnaire were evaluated at baseline, weeks 8 and 18 of treatment. Statistical analysis included generalized estimating equations models with adjustment for potential confounding factors. Results: No longitudinal changes over time were found across the different food craving scores after 18 weeks of treatment. However, adjusted models according to BMI status showed that the normal weight (NW) group presented an increased score for the "complex carbohydrates/proteins" food cravings (− 0.67; 95% CI [− 1.15, − 0.19]; P = 0.010), while baseline scores for "fast-food fats" cravings were significantly higher in the overweight/obese (OWO) group in comparison with NW patients (NW, 2.05; 95% CI [1.60, 2.49]; OWO, 2.81, 95% CI [2.37, 3.25]; P = 0.016). When considering if food craving could predict weight gain, only increments in "fast-food fats" cravings were associated (β = − 5.35 ± 1.67; 95% CI [− 8.64, − 2.06]; P = 0.001). Conclusions: No longitudinal differences were found for any of the food craving scores evaluated; however, in the NW group, food craving for "complex carbohydrates/proteins" changed. Thus, changes in "fast-food fats" cravings predicted weight increase in this sample. Interventions targeting food preferences may help to mitigate weight gain in patients starting treatment with clozapine. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s00213-019-05291-3
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Food preferences
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      – SubjectFull: Body mass index
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