Executive dysfunctions differentially predict amotivation in first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study.
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| Title: | Executive dysfunctions differentially predict amotivation in first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study. |
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| Authors: | Chang, Wing Chung (AUTHOR), Liu, Jasmine Tsz Ting (AUTHOR), Hui, Christy Lai Ming (AUTHOR), Chan, Sherry Kit Wa (AUTHOR), Lee, Edwin Ho Ming (AUTHOR), Suen, Yi Nam (AUTHOR), Chen, Eric Yu Hai (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Dec2019, Vol. 269 Issue 8, p887-896. 10p. 4 Charts. |
| Subjects: | Longitudinal method, Neuroplasticity, Response inhibition, Short-term memory, Regression analysis |
| Abstract: | Amotivation is a major determinant of functional outcome in schizophrenia but it is understudied in the early course of illness. There is a paucity of longitudinal research investigating predictors of amotivation. In this study, we aimed to examine baseline cognitive and clinical predictors of amotivation at 6 and 12 months of follow-up in patients aged 18–55 years presenting with first-episode DSM-IV schizophrenia-spectrum disorder (FES). Of 145 patients recruited at intake, 116 and 113 completed assessments at 6- and 12-month follow-up, respectively. Amotivation was measured by avolition-apathy and anhedonia-asociality subscale scores of the Scale of the Assessment of Negative Symptoms. Cognitive assessment was administered at baseline. As executive dysfunction has been more consistently found to be associated with negative symptoms and amotivation in prior literature, we adopted fractionated approach to subdivide executive function into distinct components encompassing switching and flexibility, response initiation, response inhibition, planning and strategy allocation, sustained attention and working memory. Our results showed that baseline amotivation (p = 0.01) and switching and flexibility (p = 0.01) were found to independently predict amotivation at 6 months follow-up. Baseline amotivation (p < 0.01) and switching and flexibility (albeit with trend-wise significance, p = 0.06) were also retained in final multivariate regression model for 12-month amotivation prediction. No other executive components or cognitive domains predicted amotivation at follow-up. Findings of our study thus indicate amotivation at initial presentation as a critical determinant of subsequent motivational deficits over 1 year of treatment for FES patients. Cognitive flexibility might be specifically related to the development of amotivation in the early stage of illness. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 139568289 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Executive dysfunctions differentially predict amotivation in first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chang%2C+Wing+Chung%22">Chang, Wing Chung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Jasmine+Tsz+Ting%22">Liu, Jasmine Tsz Ting</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hui%2C+Christy+Lai+Ming%22">Hui, Christy Lai Ming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Sherry+Kit+Wa%22">Chan, Sherry Kit Wa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Edwin+Ho+Ming%22">Lee, Edwin Ho Ming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Suen%2C+Yi+Nam%22">Suen, Yi Nam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Eric+Yu+Hai%22">Chen, Eric Yu Hai</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Dec2019, Vol. 269 Issue 8, p887-896. 10p. 4 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Response+inhibition%22">Response inhibition</searchLink><br /><searchLink fieldCode="DE" term="%22Short-term+memory%22">Short-term memory</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Amotivation is a major determinant of functional outcome in schizophrenia but it is understudied in the early course of illness. There is a paucity of longitudinal research investigating predictors of amotivation. In this study, we aimed to examine baseline cognitive and clinical predictors of amotivation at 6 and 12 months of follow-up in patients aged 18–55 years presenting with first-episode DSM-IV schizophrenia-spectrum disorder (FES). Of 145 patients recruited at intake, 116 and 113 completed assessments at 6- and 12-month follow-up, respectively. Amotivation was measured by avolition-apathy and anhedonia-asociality subscale scores of the Scale of the Assessment of Negative Symptoms. Cognitive assessment was administered at baseline. As executive dysfunction has been more consistently found to be associated with negative symptoms and amotivation in prior literature, we adopted fractionated approach to subdivide executive function into distinct components encompassing switching and flexibility, response initiation, response inhibition, planning and strategy allocation, sustained attention and working memory. Our results showed that baseline amotivation (p = 0.01) and switching and flexibility (p = 0.01) were found to independently predict amotivation at 6 months follow-up. Baseline amotivation (p < 0.01) and switching and flexibility (albeit with trend-wise significance, p = 0.06) were also retained in final multivariate regression model for 12-month amotivation prediction. No other executive components or cognitive domains predicted amotivation at follow-up. Findings of our study thus indicate amotivation at initial presentation as a critical determinant of subsequent motivational deficits over 1 year of treatment for FES patients. Cognitive flexibility might be specifically related to the development of amotivation in the early stage of illness. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-018-0918-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 887 Subjects: – SubjectFull: Longitudinal method Type: general – SubjectFull: Neuroplasticity Type: general – SubjectFull: Response inhibition Type: general – SubjectFull: Short-term memory Type: general – SubjectFull: Regression analysis Type: general Titles: – TitleFull: Executive dysfunctions differentially predict amotivation in first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chang, Wing Chung – PersonEntity: Name: NameFull: Liu, Jasmine Tsz Ting – PersonEntity: Name: NameFull: Hui, Christy Lai Ming – PersonEntity: Name: NameFull: Chan, Sherry Kit Wa – PersonEntity: Name: NameFull: Lee, Edwin Ho Ming – PersonEntity: Name: NameFull: Suen, Yi Nam – PersonEntity: Name: NameFull: Chen, Eric Yu Hai IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 269 – Type: issue Value: 8 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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