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Genetic variants within Ninjurin 2 gene are associated with risk of ischemic stroke in Iranian population.

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Title: Genetic variants within Ninjurin 2 gene are associated with risk of ischemic stroke in Iranian population.
Authors: Malekzadeh, Vadoud (AUTHOR), Azari, Iman (AUTHOR), Noroozi, Rezvan (AUTHOR), Shams, Roshanak (AUTHOR), Farzaneh, Mina (AUTHOR), Taheri, Mohammad (AUTHOR), Ghafouri-Fard, Soudeh (AUTHOR)
Source: Neurological Sciences. Dec2019, Vol. 40 Issue 12, p2603-2607. 5p. 5 Charts.
Subjects: Glycoproteins, Relative medical risk, Genetic polymorphisms, Case-control method, Cerebral ischemia, Stroke
Geographic Terms: Iran
Abstract: Previous genetic and epidemiological studies have shown the contribution of genetic factors in conferring the risk of ischemic stroke. Among the acknowledged risk factors of stroke are the single nucleotide polymorphisms (SNPs) near Ninjurin 2 (NINJ2) gene which encodes a surface adhesion protein. In the current study, we investigated the role of two SNPs near this gene in ischemic stroke in Iranian population. The frequency of the A allele of the rs11833579 was significantly lower in cases compared with controls (OR (95% CI) = 0.68 (0.54-0.86), adjusted P value = 0.002). The rs11833579 was significantly associated with risk of stroke in co-dominant (AA vs. GG: OR (95% CI) = 0.39 (0.23-0.66), adjusted P value = 0.003) and recessive (OR (95% CI) = 0.44 (0.27-0.72), adjusted P value = 0.001) models. The rs3809263 was associated with risk of stroke in dominant model (OR (95% CI) = 1.5 (1.09-2.06), adjusted P value = 0.02). The A C haplotype (rs11833579 and rs3809263) decreased the risk of stroke (OR (95% CI) = 0.72 (0.57-0.91), adjusted P value = 0.03), while the G T haplotype conferred susceptibility to stroke (OR (95% CI) = 1.42 (1.11-1.82), adjusted P value = 0.02). Consequently, the present case-control study supports the role of NINJ2 as a risk locus for ischemic stroke in Iranian population. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Genetic variants within Ninjurin 2 gene are associated with risk of ischemic stroke in Iranian population.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Malekzadeh%2C+Vadoud%22">Malekzadeh, Vadoud</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Azari%2C+Iman%22">Azari, Iman</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Noroozi%2C+Rezvan%22">Noroozi, Rezvan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shams%2C+Roshanak%22">Shams, Roshanak</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farzaneh%2C+Mina%22">Farzaneh, Mina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taheri%2C+Mohammad%22">Taheri, Mohammad</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghafouri-Fard%2C+Soudeh%22">Ghafouri-Fard, Soudeh</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2019, Vol. 40 Issue 12, p2603-2607. 5p. 5 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Glycoproteins%22">Glycoproteins</searchLink><br /><searchLink fieldCode="DE" term="%22Relative+medical+risk%22">Relative medical risk</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+ischemia%22">Cerebral ischemia</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Iran%22">Iran</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Previous genetic and epidemiological studies have shown the contribution of genetic factors in conferring the risk of ischemic stroke. Among the acknowledged risk factors of stroke are the single nucleotide polymorphisms (SNPs) near Ninjurin 2 (NINJ2) gene which encodes a surface adhesion protein. In the current study, we investigated the role of two SNPs near this gene in ischemic stroke in Iranian population. The frequency of the A allele of the rs11833579 was significantly lower in cases compared with controls (OR (95% CI) = 0.68 (0.54-0.86), adjusted P value = 0.002). The rs11833579 was significantly associated with risk of stroke in co-dominant (AA vs. GG: OR (95% CI) = 0.39 (0.23-0.66), adjusted P value = 0.003) and recessive (OR (95% CI) = 0.44 (0.27-0.72), adjusted P value = 0.001) models. The rs3809263 was associated with risk of stroke in dominant model (OR (95% CI) = 1.5 (1.09-2.06), adjusted P value = 0.02). The A C haplotype (rs11833579 and rs3809263) decreased the risk of stroke (OR (95% CI) = 0.72 (0.57-0.91), adjusted P value = 0.03), while the G T haplotype conferred susceptibility to stroke (OR (95% CI) = 1.42 (1.11-1.82), adjusted P value = 0.02). Consequently, the present case-control study supports the role of NINJ2 as a risk locus for ischemic stroke in Iranian population. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s10072-019-04023-x
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 2603
    Subjects:
      – SubjectFull: Glycoproteins
        Type: general
      – SubjectFull: Relative medical risk
        Type: general
      – SubjectFull: Genetic polymorphisms
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      – SubjectFull: Case-control method
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      – SubjectFull: Cerebral ischemia
        Type: general
      – SubjectFull: Stroke
        Type: general
      – SubjectFull: Iran
        Type: general
    Titles:
      – TitleFull: Genetic variants within Ninjurin 2 gene are associated with risk of ischemic stroke in Iranian population.
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              M: 12
              Text: Dec2019
              Type: published
              Y: 2019
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