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Longitudinal trajectories of neurocognitive test performance among individuals with perinatal HIV-infection and -exposure: adolescence through young adulthood.

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Title: Longitudinal trajectories of neurocognitive test performance among individuals with perinatal HIV-infection and -exposure: adolescence through young adulthood.
Authors: Robbins, Reuben N., Zimmerman, R., Korich, R., Raymond, J., Dolezal, C., Choi, C. J., Leu, C. S., Nguyen, N., Malee, K., Wiznia, A., Abrams, E. J., Mellins, C. A.
Source: AIDS Care. Jan2020, Vol. 32 Issue 1, p21-29. 9p. 4 Charts.
Subjects: Diagnosis of HIV infections, Psychology of HIV-positive persons, Longitudinal method, Neuropsychological tests, Motor ability, Short-term memory, Thought & thinking, Task performance, Executive function, Descriptive statistics, Adolescence, Adults, Children, Fetus
Abstract: There are an estimated 2.1 million youth less than 15 years of age living with HIV globally (the majority perinatally HIV-infected [PHIV]) and millions more perinatally HIV-exposed uninfected (PHEU) youth who are expected to survive through adolescence and into adulthood. Transitioning from adolescence to young adulthood requires adaptation to more demanding social interactions, academic pressures, and individual responsibilities which place distinct demands on neurocognitive functions. This study examined longitudinal trajectories of neurocognitive test performance in the domains of processing speed (PS), working memory (WM), and executive functioning (EF) among PHIV and demographically similar PHEU from adolescence through young adulthood. Data for this paper come from four time points, spanning approximately 10 years, within the Child and Adolescent Self-Awareness and Health Study (CASAH). Youth age ranged from 15 to 29 years. Longitudinal linear mixed effect models were computed for each test. Few differences in performance were found on tests of EF and WM between PHIV and PHEU youth as they aged, though PHEU youth showed significantly better PS as they aged than PHIV youth. Future research is needed to understand these vulnerable youth's neurocognitive trajectories as a function of HIV infection and -exposure, biological functions and psychosocial stressors. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Longitudinal trajectories of neurocognitive test performance among individuals with perinatal HIV-infection and -exposure: adolescence through young adulthood.
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  Data: <searchLink fieldCode="AR" term="%22Robbins%2C+Reuben+N%2E%22">Robbins, Reuben N.</searchLink><br /><searchLink fieldCode="AR" term="%22Zimmerman%2C+R%2E%22">Zimmerman, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Korich%2C+R%2E%22">Korich, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Raymond%2C+J%2E%22">Raymond, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Dolezal%2C+C%2E%22">Dolezal, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Choi%2C+C%2E+J%2E%22">Choi, C. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Leu%2C+C%2E+S%2E%22">Leu, C. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+N%2E%22">Nguyen, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Malee%2C+K%2E%22">Malee, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Wiznia%2C+A%2E%22">Wiznia, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Abrams%2C+E%2E+J%2E%22">Abrams, E. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Mellins%2C+C%2E+A%2E%22">Mellins, C. A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Jan2020, Vol. 32 Issue 1, p21-29. 9p. 4 Charts.
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  Data: There are an estimated 2.1 million youth less than 15 years of age living with HIV globally (the majority perinatally HIV-infected [PHIV]) and millions more perinatally HIV-exposed uninfected (PHEU) youth who are expected to survive through adolescence and into adulthood. Transitioning from adolescence to young adulthood requires adaptation to more demanding social interactions, academic pressures, and individual responsibilities which place distinct demands on neurocognitive functions. This study examined longitudinal trajectories of neurocognitive test performance in the domains of processing speed (PS), working memory (WM), and executive functioning (EF) among PHIV and demographically similar PHEU from adolescence through young adulthood. Data for this paper come from four time points, spanning approximately 10 years, within the Child and Adolescent Self-Awareness and Health Study (CASAH). Youth age ranged from 15 to 29 years. Longitudinal linear mixed effect models were computed for each test. Few differences in performance were found on tests of EF and WM between PHIV and PHEU youth as they aged, though PHEU youth showed significantly better PS as they aged than PHIV youth. Future research is needed to understand these vulnerable youth's neurocognitive trajectories as a function of HIV infection and -exposure, biological functions and psychosocial stressors. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/09540121.2019.1626343
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      – Code: eng
        Text: English
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        PageCount: 9
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    Subjects:
      – SubjectFull: Diagnosis of HIV infections
        Type: general
      – SubjectFull: Psychology of HIV-positive persons
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Neuropsychological tests
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      – SubjectFull: Motor ability
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      – SubjectFull: Short-term memory
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      – SubjectFull: Thought & thinking
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      – SubjectFull: Task performance
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      – SubjectFull: Executive function
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      – SubjectFull: Descriptive statistics
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