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A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.

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Title: A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.
Authors: Alexander, Peter D. (AUTHOR), Gicas, Kristina M. (AUTHOR), Cheng, Alex (AUTHOR), Lang, Donna J. (AUTHOR), Procyshyn, Ric M. (AUTHOR), Vertinsky, Alexandra T. (AUTHOR), Panenka, William J. (AUTHOR), Thornton, Allen E. (AUTHOR), Rauscher, Alexander (AUTHOR), Wong, Jamie Y. X. (AUTHOR), Chan, Tasha (AUTHOR), Jones, Andrea A. (AUTHOR), Vila-Rodriguez, F. (AUTHOR), Honer, William G. (AUTHOR), Barr, Alasdair M. (AUTHOR)
Source: Psychopharmacology. Dec2019, Vol. 236 Issue 12, p3385-3399. 15p. 2 Color Photographs, 5 Charts.
Subjects: White matter (Nerve tissue), Diffusion tensor imaging, Schizophrenia, Psychoses, Temporal lobe, City dwellers
Abstract: Rationale: Schizophrenia and stimulant-induced psychosis (SIP) represent two different forms of psychotic disorder, with different etiologies. While many of the symptoms of psychosis are common to both disorders, there have been few direct comparisons between these conditions, especially when controlling for stimulant use in individuals with schizophrenia. Objectives: We directly compared both psychotic disorders with a comprehensive battery of clinical, neurocognitive and neuroanatomical measures. This included one group with SIP (and concurrent stimulant dependence) and two groups with schizophrenia (either with or without concurrent stimulant dependence). Methods: Ninety-six participants were recruited from a marginalized urban population, which included 39 with SIP (and concurrent stimulant dependence), 18 with schizophrenia (without stimulant dependence), and 39 with schizophrenia (with concurrent stimulant dependence). All subjects had extensive clinical and neurocognitive evaluations, complemented with structural MRI including diffusion tensor imaging (DTI) sequences to determine regional brain volumes and white matter connectivity. Results: Both positive and negative symptoms were greater in the SZ-dependent group than the other two. Neurocognitive function was broadly similar. The structural brain imaging revealed lateralized changes to the left parietal/temporal lobe, in which regional volumes were smaller in the SZ-dependent than the SZ-non-dependent group. DTI analysis indicated extensive decreases in fractional anisotropy, with parallel increases in radial diffusivity, in the SIP group compared to the SZ-dependent group. Conclusions: These findings reveal both similarities and differences between SIP and schizophrenia. Furthermore, schizophrenia with concurrent stimulant dependence may be associated with a different clinical and neuroanatomical profile as compared to schizophrenia alone. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Alexander%2C+Peter+D%2E%22">Alexander, Peter D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gicas%2C+Kristina+M%2E%22">Gicas, Kristina M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Alex%22">Cheng, Alex</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lang%2C+Donna+J%2E%22">Lang, Donna J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Procyshyn%2C+Ric+M%2E%22">Procyshyn, Ric M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vertinsky%2C+Alexandra+T%2E%22">Vertinsky, Alexandra T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Panenka%2C+William+J%2E%22">Panenka, William J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thornton%2C+Allen+E%2E%22">Thornton, Allen E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rauscher%2C+Alexander%22">Rauscher, Alexander</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wong%2C+Jamie+Y%2E+X%2E%22">Wong, Jamie Y. X.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Tasha%22">Chan, Tasha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jones%2C+Andrea+A%2E%22">Jones, Andrea A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vila-Rodriguez%2C+F%2E%22">Vila-Rodriguez, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Honer%2C+William+G%2E%22">Honer, William G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barr%2C+Alasdair+M%2E%22">Barr, Alasdair M.</searchLink> (AUTHOR)
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  Data: Rationale: Schizophrenia and stimulant-induced psychosis (SIP) represent two different forms of psychotic disorder, with different etiologies. While many of the symptoms of psychosis are common to both disorders, there have been few direct comparisons between these conditions, especially when controlling for stimulant use in individuals with schizophrenia. Objectives: We directly compared both psychotic disorders with a comprehensive battery of clinical, neurocognitive and neuroanatomical measures. This included one group with SIP (and concurrent stimulant dependence) and two groups with schizophrenia (either with or without concurrent stimulant dependence). Methods: Ninety-six participants were recruited from a marginalized urban population, which included 39 with SIP (and concurrent stimulant dependence), 18 with schizophrenia (without stimulant dependence), and 39 with schizophrenia (with concurrent stimulant dependence). All subjects had extensive clinical and neurocognitive evaluations, complemented with structural MRI including diffusion tensor imaging (DTI) sequences to determine regional brain volumes and white matter connectivity. Results: Both positive and negative symptoms were greater in the SZ-dependent group than the other two. Neurocognitive function was broadly similar. The structural brain imaging revealed lateralized changes to the left parietal/temporal lobe, in which regional volumes were smaller in the SZ-dependent than the SZ-non-dependent group. DTI analysis indicated extensive decreases in fractional anisotropy, with parallel increases in radial diffusivity, in the SIP group compared to the SZ-dependent group. Conclusions: These findings reveal both similarities and differences between SIP and schizophrenia. Furthermore, schizophrenia with concurrent stimulant dependence may be associated with a different clinical and neuroanatomical profile as compared to schizophrenia alone. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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