Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring.
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| Title: | Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring. |
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| Authors: | Fant, Bruno (AUTHOR), Wimmer, Mathieu E. (AUTHOR), Swinford-Jackson, Sarah E. (AUTHOR), Maurer, John (AUTHOR), Van Nest, Duncan (AUTHOR), Pierce, R. Christopher (AUTHOR) |
| Source: | Psychopharmacology. Dec2019, Vol. 236 Issue 12, p3429-3437. 9p. 1 Chart, 3 Graphs. |
| Subjects: | Cocaine, Drug abstinence, Pharmacology, Rat behavior |
| Abstract: | Rationale: Although the influence of gestational cocaine exposure on offspring has been the focus of a sustained research effort, the effect of preconception cocaine self-administration by dams on progeny has received far less attention. Method: In the current study, adult female rats were allowed to self-administer cocaine 2 h a day for 60 days and then after a 10-day wash out period, bred to naïve males. Maternal behavior was measured in dams until weaning. When male and female progeny reached adulthood, anxiety-like behavior, memory, and cocaine self-administration were assessed in separate cohorts of rats. Results: Despite a total of at least 30 days of cocaine abstinence, the quality of maternal behaviors was negatively affected by previous cocaine exposure as reflected by less time spent with pups as well as an excess of other maladaptive maternal behaviors. Measures of anxiety-like behavior and memory were not affected by maternal cocaine intake in either male or female offspring. In contrast, male, but not female, the progeny of dams exposed to cocaine showed increased reinforcing efficacy of cocaine as measured by cocaine self-administration under a progressive ratio schedule. The fact that cocaine self-administration was influenced only in the male offspring of cocaine-exposed dams argues against this phenotype being linked to altered maternal behavior, although this possibility cannot be ruled out completely. Conclusions: Collectively, these results indicate that preconception cocaine self-administration by dams results in the relatively selective enhancement of cocaine addiction-like behavior in male offspring. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 140160531 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fant%2C+Bruno%22">Fant, Bruno</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wimmer%2C+Mathieu+E%2E%22">Wimmer, Mathieu E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Swinford-Jackson%2C+Sarah+E%2E%22">Swinford-Jackson, Sarah E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maurer%2C+John%22">Maurer, John</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Nest%2C+Duncan%22">Van Nest, Duncan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pierce%2C+R%2E+Christopher%22">Pierce, R. Christopher</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Dec2019, Vol. 236 Issue 12, p3429-3437. 9p. 1 Chart, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cocaine%22">Cocaine</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abstinence%22">Drug abstinence</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacology%22">Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Rat+behavior%22">Rat behavior</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Although the influence of gestational cocaine exposure on offspring has been the focus of a sustained research effort, the effect of preconception cocaine self-administration by dams on progeny has received far less attention. Method: In the current study, adult female rats were allowed to self-administer cocaine 2 h a day for 60 days and then after a 10-day wash out period, bred to naïve males. Maternal behavior was measured in dams until weaning. When male and female progeny reached adulthood, anxiety-like behavior, memory, and cocaine self-administration were assessed in separate cohorts of rats. Results: Despite a total of at least 30 days of cocaine abstinence, the quality of maternal behaviors was negatively affected by previous cocaine exposure as reflected by less time spent with pups as well as an excess of other maladaptive maternal behaviors. Measures of anxiety-like behavior and memory were not affected by maternal cocaine intake in either male or female offspring. In contrast, male, but not female, the progeny of dams exposed to cocaine showed increased reinforcing efficacy of cocaine as measured by cocaine self-administration under a progressive ratio schedule. The fact that cocaine self-administration was influenced only in the male offspring of cocaine-exposed dams argues against this phenotype being linked to altered maternal behavior, although this possibility cannot be ruled out completely. Conclusions: Collectively, these results indicate that preconception cocaine self-administration by dams results in the relatively selective enhancement of cocaine addiction-like behavior in male offspring. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-019-05307-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 3429 Subjects: – SubjectFull: Cocaine Type: general – SubjectFull: Drug abstinence Type: general – SubjectFull: Pharmacology Type: general – SubjectFull: Rat behavior Type: general Titles: – TitleFull: Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fant, Bruno – PersonEntity: Name: NameFull: Wimmer, Mathieu E. – PersonEntity: Name: NameFull: Swinford-Jackson, Sarah E. – PersonEntity: Name: NameFull: Maurer, John – PersonEntity: Name: NameFull: Van Nest, Duncan – PersonEntity: Name: NameFull: Pierce, R. Christopher IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 236 – Type: issue Value: 12 Titles: – TitleFull: Psychopharmacology Type: main |
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