Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.
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| Title: | Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area. |
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| Authors: | Quintana, Gonzalo R. (AUTHOR), Birrel, Morgan (AUTHOR), Marceau, Sarah (AUTHOR), Kalantari, Narges (AUTHOR), Bowden, James (AUTHOR), Bachoura, Yvonne (AUTHOR), Borduas, Eric (AUTHOR), Lemay, Valerie (AUTHOR), Payne, Jason W. (AUTHOR), Cionnaith, Conall Mac (AUTHOR), Pfaus, James G. (AUTHOR) |
| Source: | Psychopharmacology. Dec2019, Vol. 236 Issue 12, p3613-3623. 11p. 1 Black and White Photograph, 1 Chart, 2 Graphs. |
| Subjects: | Preoptic area, Odors, Conditioned response, Male ejaculation, Rats, Naloxone |
| Abstract: | Rationale: Male rats trained to associate a neutral odor or rodent jacket on a female with their post-ejaculatory reward state display a preference to ejaculate with females bearing the odor or jacket. This conditioned ejaculatory preference (CEP) can be shifted by systemic administration of the opioid antagonist naloxone (NAL) during training, such that NAL-trained males distribute their ejaculations to females without the cue, relative to saline (SAL)-trained males. Objective: The present study examined two brain sites, the medial preoptic area (mPOA) or ventral tegmental area (VTA), where the opioid reward state might be induced. Methods: Sexually naïve Long-Evans males were implanted with bilateral guide cannula aimed at either site before they underwent multi-ejaculatory conditioning trials at 4-day intervals with sexually receptive females that bore either an almond odor or rodent tethering jacket. Infusions of NAL (1 μl/side) or SAL (1 μl/side) were made prior to each conditioning trial. All males were infused with SAL prior to a final open-field choice test with two sexually receptive females, one scented and the other unscented, or one jacketed and the other unjacketed. Results: Males previously conditioned with SAL in either region showed significant CEP. In contrast, prior infusions of NAL to the mPOA shifted the preference towards the unfamiliar female, whereas prior infusions to the VTA abolished CEP for the odor. Subsequent detection of Fos protein induced by the cue showed that, relative to SAL-treated males, prior experience with NAL in the mPOA suppressed Fos in both the mPOA and VTA, whereas prior experience with NAL in to the VTA suppressed Fos in the VTA alone. Conclusions: Opioid antagonism in the mPOA produces a state of non-reward whereas in the VTA, it produces a state in which the odor does not acquire incentive properties. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 140160545 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Quintana%2C+Gonzalo+R%2E%22">Quintana, Gonzalo R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Birrel%2C+Morgan%22">Birrel, Morgan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marceau%2C+Sarah%22">Marceau, Sarah</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kalantari%2C+Narges%22">Kalantari, Narges</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bowden%2C+James%22">Bowden, James</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bachoura%2C+Yvonne%22">Bachoura, Yvonne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Borduas%2C+Eric%22">Borduas, Eric</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lemay%2C+Valerie%22">Lemay, Valerie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Payne%2C+Jason+W%2E%22">Payne, Jason W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cionnaith%2C+Conall+Mac%22">Cionnaith, Conall Mac</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pfaus%2C+James+G%2E%22">Pfaus, James G.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Dec2019, Vol. 236 Issue 12, p3613-3623. 11p. 1 Black and White Photograph, 1 Chart, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Preoptic+area%22">Preoptic area</searchLink><br /><searchLink fieldCode="DE" term="%22Odors%22">Odors</searchLink><br /><searchLink fieldCode="DE" term="%22Conditioned+response%22">Conditioned response</searchLink><br /><searchLink fieldCode="DE" term="%22Male+ejaculation%22">Male ejaculation</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Naloxone%22">Naloxone</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Male rats trained to associate a neutral odor or rodent jacket on a female with their post-ejaculatory reward state display a preference to ejaculate with females bearing the odor or jacket. This conditioned ejaculatory preference (CEP) can be shifted by systemic administration of the opioid antagonist naloxone (NAL) during training, such that NAL-trained males distribute their ejaculations to females without the cue, relative to saline (SAL)-trained males. Objective: The present study examined two brain sites, the medial preoptic area (mPOA) or ventral tegmental area (VTA), where the opioid reward state might be induced. Methods: Sexually naïve Long-Evans males were implanted with bilateral guide cannula aimed at either site before they underwent multi-ejaculatory conditioning trials at 4-day intervals with sexually receptive females that bore either an almond odor or rodent tethering jacket. Infusions of NAL (1 μl/side) or SAL (1 μl/side) were made prior to each conditioning trial. All males were infused with SAL prior to a final open-field choice test with two sexually receptive females, one scented and the other unscented, or one jacketed and the other unjacketed. Results: Males previously conditioned with SAL in either region showed significant CEP. In contrast, prior infusions of NAL to the mPOA shifted the preference towards the unfamiliar female, whereas prior infusions to the VTA abolished CEP for the odor. Subsequent detection of Fos protein induced by the cue showed that, relative to SAL-treated males, prior experience with NAL in the mPOA suppressed Fos in both the mPOA and VTA, whereas prior experience with NAL in to the VTA suppressed Fos in the VTA alone. Conclusions: Opioid antagonism in the mPOA produces a state of non-reward whereas in the VTA, it produces a state in which the odor does not acquire incentive properties. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-019-05334-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 3613 Subjects: – SubjectFull: Preoptic area Type: general – SubjectFull: Odors Type: general – SubjectFull: Conditioned response Type: general – SubjectFull: Male ejaculation Type: general – SubjectFull: Rats Type: general – SubjectFull: Naloxone Type: general Titles: – TitleFull: Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Quintana, Gonzalo R. – PersonEntity: Name: NameFull: Birrel, Morgan – PersonEntity: Name: NameFull: Marceau, Sarah – PersonEntity: Name: NameFull: Kalantari, Narges – PersonEntity: Name: NameFull: Bowden, James – PersonEntity: Name: NameFull: Bachoura, Yvonne – PersonEntity: Name: NameFull: Borduas, Eric – PersonEntity: Name: NameFull: Lemay, Valerie – PersonEntity: Name: NameFull: Payne, Jason W. – PersonEntity: Name: NameFull: Cionnaith, Conall Mac – PersonEntity: Name: NameFull: Pfaus, James G. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 236 – Type: issue Value: 12 Titles: – TitleFull: Psychopharmacology Type: main |
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