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The efficiency of a carbamazepine–mianserin combination scheme in opiate detoxification.

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Title: The efficiency of a carbamazepine–mianserin combination scheme in opiate detoxification.
Authors: Zullino, Daniele F., Krenz, Sonia, Favrat, Bernard, Zimmermann, Grégoire, Bertschy, Gilles, Besson, Jacques
Source: Human Psychopharmacology: Clinical & Experimental. Aug2004, Vol. 19 Issue 6, p425-430. 6p. 1 Chart.
Subjects: Drug withdrawal symptoms, Carbamazepine, Narcotics, Detoxification (Alternative medicine), Antidepressants, Anticonvulsants
Abstract: A recent comparative randomized double-blind study has suggested the utility of a carbamazepine/mianserin combination as a treatment for opiate withdrawal. The aim of the present study was to explore the feasibility and efficiency of this combination under naturalistic conditions. Five hundred and fifty mostly polysubstance abusing patients treated with a standardized scheme combining carbamazepine and mianserin were assessed with regard to deviations to the protocol, used comedications and retention in treatment. Three hundred and sixty three patients (66.0%) received the carbamazepine/mianserin combination as specified by the standardized protocol. In 350 patients (63.7%) the whole 10 days was completed. The most frequently used p.r.n. medications were for anxiety (47.5%) and insomnia (54.5%). The treatment of opiate withdrawal with a carbamazepine/mianserin combination scheme in an inpatient setting seems to be feasible and applicable with few adaptations to most patients, and may represent an interesting treatment option for multidrug users.. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The efficiency of a carbamazepine–mianserin combination scheme in opiate detoxification.
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  Data: <searchLink fieldCode="AR" term="%22Zullino%2C+Daniele+F%2E%22">Zullino, Daniele F.</searchLink><br /><searchLink fieldCode="AR" term="%22Krenz%2C+Sonia%22">Krenz, Sonia</searchLink><br /><searchLink fieldCode="AR" term="%22Favrat%2C+Bernard%22">Favrat, Bernard</searchLink><br /><searchLink fieldCode="AR" term="%22Zimmermann%2C+Grégoire%22">Zimmermann, Grégoire</searchLink><br /><searchLink fieldCode="AR" term="%22Bertschy%2C+Gilles%22">Bertschy, Gilles</searchLink><br /><searchLink fieldCode="AR" term="%22Besson%2C+Jacques%22">Besson, Jacques</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Aug2004, Vol. 19 Issue 6, p425-430. 6p. 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Drug+withdrawal+symptoms%22">Drug withdrawal symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Carbamazepine%22">Carbamazepine</searchLink><br /><searchLink fieldCode="DE" term="%22Narcotics%22">Narcotics</searchLink><br /><searchLink fieldCode="DE" term="%22Detoxification+%28Alternative+medicine%29%22">Detoxification (Alternative medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Anticonvulsants%22">Anticonvulsants</searchLink>
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  Data: A recent comparative randomized double-blind study has suggested the utility of a carbamazepine/mianserin combination as a treatment for opiate withdrawal. The aim of the present study was to explore the feasibility and efficiency of this combination under naturalistic conditions. Five hundred and fifty mostly polysubstance abusing patients treated with a standardized scheme combining carbamazepine and mianserin were assessed with regard to deviations to the protocol, used comedications and retention in treatment. Three hundred and sixty three patients (66.0%) received the carbamazepine/mianserin combination as specified by the standardized protocol. In 350 patients (63.7%) the whole 10 days was completed. The most frequently used p.r.n. medications were for anxiety (47.5%) and insomnia (54.5%). The treatment of opiate withdrawal with a carbamazepine/mianserin combination scheme in an inpatient setting seems to be feasible and applicable with few adaptations to most patients, and may represent an interesting treatment option for multidrug users.. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=14076764
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              Text: Aug2004
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