View in EDS HTML Full Text PDF Full Text

Plasma levels of protein C pathway proteins and brain magnetic resonance imaging volumes in multiple sclerosis.

Saved in:
Bibliographic Details
Title: Plasma levels of protein C pathway proteins and brain magnetic resonance imaging volumes in multiple sclerosis.
Authors: Ziliotto, N. (AUTHOR), Zivadinov, R. (AUTHOR), Baroni, M. (AUTHOR), Marchetti, G. (AUTHOR), Jakimovski, D. (AUTHOR), Bergsland, N. (AUTHOR), Ramasamy, D. P. (AUTHOR), Weinstock‐Guttman, B. (AUTHOR), Straudi, S. (AUTHOR), Manfredini, F. (AUTHOR), Ramanathan, M. (AUTHOR), Bernardi, F. (AUTHOR)
Source: European Journal of Neurology. Feb2020, Vol. 27 Issue 2, p235-243. 9p. 4 Charts, 2 Graphs.
Subjects: Protein C, Blood proteins, Magnetic resonance imaging, Multiple sclerosis, Brain proteins
Abstract: Background and purpose: The involvement of protein C (PC) pathway components in multiple sclerosis (MS) has scarcely been explored. The aim was to investigate their levels in relation to clinical and neurodegenerative magnetic resonance imaging (MRI) outcomes in patients. Methods: In all, 138 MS patients and 42 healthy individuals were studied. PC, protein S (PS) and soluble endothelial protein C receptor (sEPCR) were evaluated by multiplex assays and enzyme‐linked immunosorbent assay. Regression analyses between 3 T MRI outcomes and PC pathway components were performed. ancova was used to compare MRI volumes based on protein level quartiles. Partial correlation was assessed amongst levels of PC pathway components and hemostasis protein levels, including soluble thrombomodulin (sTM), heparin cofactor II (HCII), plasminogen activator inhibitor 1 (PAI‐1) and factor XII (FXII). The variation of PC concentration across four time points was evaluated in 32 additional MS patients. Results: There was an association between PC concentration, mainly reflecting the zymogen PC, and MRI measures for volumes of total gray matter (GM) (P = 0.003), thalamus (P = 0.007), cortex (P = 0.008), deep GM (P = 0.009) and whole brain (P = 0.026). Patients in the highest PC level quartile were characterized by the lowest GM volumes. Correlations of PC–HCII, PC–FXII and sEPCR–sTM values were detectable in MS patients, whilst PC–PS and PS–PAI‐1 correlations were present in healthy individuals only. Conclusions: Protein C plasma concentrations might be associated with neurodegenerative MRI outcomes in MS. Several differences in correlation amongst protein plasma levels suggest dysregulation of PC pathway components in MS patients. The stability of PC concentration over time supports a PC investigation in relation to GM atrophy in MS. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 141075992
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Plasma levels of protein C pathway proteins and brain magnetic resonance imaging volumes in multiple sclerosis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ziliotto%2C+N%2E%22">Ziliotto, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zivadinov%2C+R%2E%22">Zivadinov, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baroni%2C+M%2E%22">Baroni, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marchetti%2C+G%2E%22">Marchetti, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jakimovski%2C+D%2E%22">Jakimovski, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bergsland%2C+N%2E%22">Bergsland, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramasamy%2C+D%2E+P%2E%22">Ramasamy, D. P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weinstock‐Guttman%2C+B%2E%22">Weinstock‐Guttman, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Straudi%2C+S%2E%22">Straudi, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manfredini%2C+F%2E%22">Manfredini, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramanathan%2C+M%2E%22">Ramanathan, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bernardi%2C+F%2E%22">Bernardi, F.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Feb2020, Vol. 27 Issue 2, p235-243. 9p. 4 Charts, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Protein+C%22">Protein C</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+proteins%22">Blood proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+proteins%22">Brain proteins</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose: The involvement of protein C (PC) pathway components in multiple sclerosis (MS) has scarcely been explored. The aim was to investigate their levels in relation to clinical and neurodegenerative magnetic resonance imaging (MRI) outcomes in patients. Methods: In all, 138 MS patients and 42 healthy individuals were studied. PC, protein S (PS) and soluble endothelial protein C receptor (sEPCR) were evaluated by multiplex assays and enzyme‐linked immunosorbent assay. Regression analyses between 3 T MRI outcomes and PC pathway components were performed. ancova was used to compare MRI volumes based on protein level quartiles. Partial correlation was assessed amongst levels of PC pathway components and hemostasis protein levels, including soluble thrombomodulin (sTM), heparin cofactor II (HCII), plasminogen activator inhibitor 1 (PAI‐1) and factor XII (FXII). The variation of PC concentration across four time points was evaluated in 32 additional MS patients. Results: There was an association between PC concentration, mainly reflecting the zymogen PC, and MRI measures for volumes of total gray matter (GM) (P = 0.003), thalamus (P = 0.007), cortex (P = 0.008), deep GM (P = 0.009) and whole brain (P = 0.026). Patients in the highest PC level quartile were characterized by the lowest GM volumes. Correlations of PC–HCII, PC–FXII and sEPCR–sTM values were detectable in MS patients, whilst PC–PS and PS–PAI‐1 correlations were present in healthy individuals only. Conclusions: Protein C plasma concentrations might be associated with neurodegenerative MRI outcomes in MS. Several differences in correlation amongst protein plasma levels suggest dysregulation of PC pathway components in MS patients. The stability of PC concentration over time supports a PC investigation in relation to GM atrophy in MS. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=141075992
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ene.14058
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 235
    Subjects:
      – SubjectFull: Protein C
        Type: general
      – SubjectFull: Blood proteins
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Multiple sclerosis
        Type: general
      – SubjectFull: Brain proteins
        Type: general
    Titles:
      – TitleFull: Plasma levels of protein C pathway proteins and brain magnetic resonance imaging volumes in multiple sclerosis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ziliotto, N.
      – PersonEntity:
          Name:
            NameFull: Zivadinov, R.
      – PersonEntity:
          Name:
            NameFull: Baroni, M.
      – PersonEntity:
          Name:
            NameFull: Marchetti, G.
      – PersonEntity:
          Name:
            NameFull: Jakimovski, D.
      – PersonEntity:
          Name:
            NameFull: Bergsland, N.
      – PersonEntity:
          Name:
            NameFull: Ramasamy, D. P.
      – PersonEntity:
          Name:
            NameFull: Weinstock‐Guttman, B.
      – PersonEntity:
          Name:
            NameFull: Straudi, S.
      – PersonEntity:
          Name:
            NameFull: Manfredini, F.
      – PersonEntity:
          Name:
            NameFull: Ramanathan, M.
      – PersonEntity:
          Name:
            NameFull: Bernardi, F.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 27
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1