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Impact of adjuvant therapy on survival for sinonasal mucosal melanoma.

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Title: Impact of adjuvant therapy on survival for sinonasal mucosal melanoma.
Authors: Lai, Yuting (AUTHOR), Meng, Xinjun (AUTHOR), Liu, Quan (AUTHOR), Lu, Hanyu (AUTHOR), Guo, Limin (AUTHOR), Wang, Shuyi (AUTHOR), Wang, Dehui (AUTHOR)
Source: Acta Oto-Laryngologica. Jan2020, Vol. 140 Issue 1, p79-84. 6p.
Subjects: Melanoma prognosis, Melanoma treatment, Risk of metastasis, Adjuvant treatment of cancer, Cancer relapse, Combined modality therapy, Endoscopy, Nasal mucosa, Risk assessment, Survival analysis (Biometry), Treatment effectiveness, Retrospective studies, Kaplan-Meier estimator, Log-rank test, Chemoradiotherapy, Disease risk factors
Abstract (English): Background: The optimal treatment modality for sinonasal mucosal melanoma (SNMM) remains controversial. Objectives: To investigate the impact of adjuvant therapy on SNMM. Material and methods: Ninety-two patients were retrospectively analyzed and were grouped into surgery alone (SA), surgery plus radiotherapy (SR), surgery plus chemotherapy (SC) and surgery plus radiochemotherapy (SRC) groups. Survival outcomes among different treatment modalities were analyzed using the Kaplan–Meier method and log-rank test. Results: Twenty-nine patients (31.5%) developed local recurrence, 10 patients (10.9%) had nodal metastasis, and 41 patients (44.6%) had distant metastasis. The overall survival time (OS) for SA, SR and SRC were 16, 29 and 27 months, respectively, and the disease-free survival time (DFS) were 10, 16 and 16 months, respectively. Significant differences were found between SA and SR (OS: p =.003; DFS: p =.016) and SA and SRC (OS: p =.002; DFS: p =.008). Superior outcomes were also found in SRC group compared to that in SA group for both OS (15 vs. 27 months, p =.012) and DFS (10 vs. 20 months, p =.017) in endoscopic approach. Conclusions and significance: SNMM had poor prognosis with high rates of local recurrence and metastasis. Adjuvant therapy improved survival outcomes for SNMM. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 背景：鼻腔粘膜黑色素瘤（SNMM）的最佳治疗方式仍存有争议。 目的：探讨辅助治疗对SNMM的影响。 材料与方法：对92例患者进行回顾性分析, 将其分为单纯手术组（SA）、手术加放疗组（SR）、手术加化疗组（SC）和手术加放化疗组（SRC）。采用Kaplan-Meier法和对数秩检验来分析不同治疗方式的生存率。 结果：局部复发29例（31.5%）, 淋巴结转移10例（10.9%）, 远处转移41例（44.6%）。SA、SR和SRC的总生存期分别为16、29和27个月, 无病生存期分别为10、16和16个月。SA和SR（OS: p =.003；DFS: p =.016）和SA和SRC（OS: p =.002；DFS: p =.008）之间存在显著差异。SRC组在内镜手术中OS（15个月对27个月, p =.012）和DFS（10个月对20个月, p =.017）的疗效也优于SA组。 结论与意义：SNMM预后差, 局部复发转移率高。辅助治疗提高了SNMM的生存率。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Impact of adjuvant therapy on survival for sinonasal mucosal melanoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lai%2C+Yuting%22">Lai, Yuting</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meng%2C+Xinjun%22">Meng, Xinjun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Quan%22">Liu, Quan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Hanyu%22">Lu, Hanyu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Limin%22">Guo, Limin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Shuyi%22">Wang, Shuyi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Dehui%22">Wang, Dehui</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jan2020, Vol. 140 Issue 1, p79-84. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Melanoma+prognosis%22">Melanoma prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Melanoma+treatment%22">Melanoma treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+of+metastasis%22">Risk of metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Adjuvant+treatment+of+cancer%22">Adjuvant treatment of cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+relapse%22">Cancer relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Combined+modality+therapy%22">Combined modality therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Endoscopy%22">Endoscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Nasal+mucosa%22">Nasal mucosa</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+analysis+%28Biometry%29%22">Survival analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Kaplan-Meier+estimator%22">Kaplan-Meier estimator</searchLink><br /><searchLink fieldCode="DE" term="%22Log-rank+test%22">Log-rank test</searchLink><br /><searchLink fieldCode="DE" term="%22Chemoradiotherapy%22">Chemoradiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: The optimal treatment modality for sinonasal mucosal melanoma (SNMM) remains controversial. Objectives: To investigate the impact of adjuvant therapy on SNMM. Material and methods: Ninety-two patients were retrospectively analyzed and were grouped into surgery alone (SA), surgery plus radiotherapy (SR), surgery plus chemotherapy (SC) and surgery plus radiochemotherapy (SRC) groups. Survival outcomes among different treatment modalities were analyzed using the Kaplan–Meier method and log-rank test. Results: Twenty-nine patients (31.5%) developed local recurrence, 10 patients (10.9%) had nodal metastasis, and 41 patients (44.6%) had distant metastasis. The overall survival time (OS) for SA, SR and SRC were 16, 29 and 27 months, respectively, and the disease-free survival time (DFS) were 10, 16 and 16 months, respectively. Significant differences were found between SA and SR (OS: p =.003; DFS: p =.016) and SA and SRC (OS: p =.002; DFS: p =.008). Superior outcomes were also found in SRC group compared to that in SA group for both OS (15 vs. 27 months, p =.012) and DFS (10 vs. 20 months, p =.017) in endoscopic approach. Conclusions and significance: SNMM had poor prognosis with high rates of local recurrence and metastasis. Adjuvant therapy improved survival outcomes for SNMM. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 背景：鼻腔粘膜黑色素瘤（SNMM）的最佳治疗方式仍存有争议。 目的：探讨辅助治疗对SNMM的影响。 材料与方法：对92例患者进行回顾性分析, 将其分为单纯手术组（SA）、手术加放疗组（SR）、手术加化疗组（SC）和手术加放化疗组（SRC）。采用Kaplan-Meier法和对数秩检验来分析不同治疗方式的生存率。 结果：局部复发29例（31.5%）, 淋巴结转移10例（10.9%）, 远处转移41例（44.6%）。SA、SR和SRC的总生存期分别为16、29和27个月, 无病生存期分别为10、16和16个月。SA和SR（OS: p =.003；DFS: p =.016）和SA和SRC（OS: p =.002；DFS: p =.008）之间存在显著差异。SRC组在内镜手术中OS（15个月对27个月, p =.012）和DFS（10个月对20个月, p =.017）的疗效也优于SA组。 结论与意义：SNMM预后差, 局部复发转移率高。辅助治疗提高了SNMM的生存率。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2019.1635269
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 79
    Subjects:
      – SubjectFull: Melanoma prognosis
        Type: general
      – SubjectFull: Melanoma treatment
        Type: general
      – SubjectFull: Risk of metastasis
        Type: general
      – SubjectFull: Adjuvant treatment of cancer
        Type: general
      – SubjectFull: Cancer relapse
        Type: general
      – SubjectFull: Combined modality therapy
        Type: general
      – SubjectFull: Endoscopy
        Type: general
      – SubjectFull: Nasal mucosa
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Survival analysis (Biometry)
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Retrospective studies
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      – SubjectFull: Kaplan-Meier estimator
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      – SubjectFull: Log-rank test
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      – SubjectFull: Chemoradiotherapy
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      – SubjectFull: Disease risk factors
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      – TitleFull: Impact of adjuvant therapy on survival for sinonasal mucosal melanoma.
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              Text: Jan2020
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