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Striatal functional connectivity in chronic ketamine users: a pilot study.

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Title: Striatal functional connectivity in chronic ketamine users: a pilot study.
Authors: Hung, Chia-Chun (AUTHOR), Zhang, Sheng (AUTHOR), Chen, Chun-Ming (AUTHOR), Duann, Jeng-Ren (AUTHOR), Lin, Ching-Po (AUTHOR), Lee, Tony Szu-Hsien (AUTHOR), Li, Chiang-Shan R. (AUTHOR)
Source: American Journal of Drug & Alcohol Abuse. 2020, Vol. 46 Issue 1, p31-43. 13p.
Subjects: Magnetic resonance imaging, Cingulate cortex, Pilot projects, Drug addiction
Abstract: Background: The striatum supports motivated behavior and impulse control. Altered striatal activation and connectivity has been observed in link with impulse control dysfunction in individuals with drug addiction.Objectives: We examined how resting state functional connectivity (rsFC) of the striatum is altered as a result of chronic ketamine misuse.Methods: Thirty-six ketamine users (10 women) and 20 healthy controls (9 women) completed an assessment with the Barratt Impulsiveness Scale (BIS-11) and magnetic resonance imaging. In SPM we examined voxel-wise connectivities of the caudate, pallidum, putamen, and ventral striatum in ketamine users (versus healthy controls) and in association with BIS-11 score and duration of use, all at a corrected threshold.Results: Compared to controls, ketamine users showed higher connectivity between caudate and dorsal anterior cingulate cortex and between pallidum and bilateral cerebellum. In ketamine users, putamen showed higher connectivity with the left orbitofrontal cortex (OFC) in association with both BIS-11 score and months of ketamine use. Mediation analyses suggest that the connectivity z score mediated the relationship between impulsivity and duration of use.Conclusions: These preliminary findings highlighted altered striatal connectivity in chronic ketamine users, and the potential role of putamen OFC connectivity in supporting the correlation between impulsivity and duration of ketamine use. If replicated in a larger sample, these findings may represent neural markers of ketamine misuse. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Striatal functional connectivity in chronic ketamine users: a pilot study.
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  Data: <searchLink fieldCode="AR" term="%22Hung%2C+Chia-Chun%22">Hung, Chia-Chun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Sheng%22">Zhang, Sheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Chun-Ming%22">Chen, Chun-Ming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duann%2C+Jeng-Ren%22">Duann, Jeng-Ren</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Ching-Po%22">Lin, Ching-Po</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Tony+Szu-Hsien%22">Lee, Tony Szu-Hsien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Chiang-Shan+R%2E%22">Li, Chiang-Shan R.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Drug+%26+Alcohol+Abuse%22">American Journal of Drug & Alcohol Abuse</searchLink>. 2020, Vol. 46 Issue 1, p31-43. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Cingulate+cortex%22">Cingulate cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+addiction%22">Drug addiction</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: The striatum supports motivated behavior and impulse control. Altered striatal activation and connectivity has been observed in link with impulse control dysfunction in individuals with drug addiction.Objectives: We examined how resting state functional connectivity (rsFC) of the striatum is altered as a result of chronic ketamine misuse.Methods: Thirty-six ketamine users (10 women) and 20 healthy controls (9 women) completed an assessment with the Barratt Impulsiveness Scale (BIS-11) and magnetic resonance imaging. In SPM we examined voxel-wise connectivities of the caudate, pallidum, putamen, and ventral striatum in ketamine users (versus healthy controls) and in association with BIS-11 score and duration of use, all at a corrected threshold.Results: Compared to controls, ketamine users showed higher connectivity between caudate and dorsal anterior cingulate cortex and between pallidum and bilateral cerebellum. In ketamine users, putamen showed higher connectivity with the left orbitofrontal cortex (OFC) in association with both BIS-11 score and months of ketamine use. Mediation analyses suggest that the connectivity z score mediated the relationship between impulsivity and duration of use.Conclusions: These preliminary findings highlighted altered striatal connectivity in chronic ketamine users, and the potential role of putamen OFC connectivity in supporting the correlation between impulsivity and duration of ketamine use. If replicated in a larger sample, these findings may represent neural markers of ketamine misuse. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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