Tired and stressed: Examining the need for sleep.

Saved in:

Bibliographic Details
Title:	Tired and stressed: Examining the need for sleep.
Authors:	Hill, Vanessa M. (AUTHOR), O'Connor, Reed M. (AUTHOR), Shirasu-Hiza, Mimi (AUTHOR)
Source:	European Journal of Neuroscience. Jan2020, Vol. 51 Issue 1, p494-508. 15p.
Subjects:	Non-REM sleep, Somnology, Sleep, Drosophila melanogaster, Circadian rhythms, Free radicals
Abstract:	A key feature of circadian rhythms is the sleep/wake cycle. Sleep causes reduced responsiveness to the environment, which puts animals in a particularly vulnerable state; yet sleep has been conserved throughout evolution, indicating that it fulfils a vital purpose. A core function of sleep across species has not been identified, but substantial advances in sleep research have been made in recent years using the genetically tractable model organism, Drosophila melanogaster. This review describes the universality of sleep, the regulation of sleep, and current theories on the function of sleep, highlighting a historical and often overlooked theory called the Free Radical Flux Theory of Sleep. Additionally, we summarize our recent work with short‐sleeping Drosophila mutants and other genetic and pharmacological tools for manipulating sleep which supports an antioxidant theory of sleep and demonstrates a bi‐directional relationship between sleep and oxidative stress. [ABSTRACT FROM AUTHOR]
	Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	A key feature of circadian rhythms is the sleep/wake cycle. Sleep causes reduced responsiveness to the environment, which puts animals in a particularly vulnerable state; yet sleep has been conserved throughout evolution, indicating that it fulfils a vital purpose. A core function of sleep across species has not been identified, but substantial advances in sleep research have been made in recent years using the genetically tractable model organism, Drosophila melanogaster. This review describes the universality of sleep, the regulation of sleep, and current theories on the function of sleep, highlighting a historical and often overlooked theory called the Free Radical Flux Theory of Sleep. Additionally, we summarize our recent work with short‐sleeping Drosophila mutants and other genetic and pharmacological tools for manipulating sleep which supports an antioxidant theory of sleep and demonstrates a bi‐directional relationship between sleep and oxidative stress. [ABSTRACT FROM AUTHOR]
ISSN:	0953816X
DOI:	10.1111/ejn.14197