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No Gastrointestinal Dysmotility in Transgenic Mouse Models of Migraine.

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Title: No Gastrointestinal Dysmotility in Transgenic Mouse Models of Migraine.
Authors: Sprouse Blum, Adam S., Lavoie, Brigitte, Haag, Melody, Mawe, Seamus M., Tolner, Else A., Maagdenberg, Arn M.J.M., Chen, Shih‐Pin, Eikermann‐Haerter, Katharina, Ptáček, Louis, Mawe, Gary M., Shapiro, Robert E.
Source: Headache: The Journal of Head & Face Pain. Feb2020, Vol. 60 Issue 2, p396-404. 9p. 3 Graphs.
Subjects: Therapeutic use of nitroglycerin, Animal experimentation, Gastrointestinal diseases, Gastrointestinal motility, Mice, Migraine, Genetic mutation, Nitroglycerin, Transgenic animals
Abstract: Objective: To determine whether transgenic mouse models of migraine exhibit upper gastrointestinal dysmotility comparable to those observed in migraine patients. Background: There is considerable evidence supporting the comorbidity of gastrointestinal dysmotility and migraine. Gastrointestinal motility, however, has never been investigated in transgenic mouse models of migraine. Methods: Three transgenic mouse strains that express pathogenic gene mutations linked to monogenic migraine‐relevant phenotypes were studied: CADASIL (Notch3‐Tg88), FASP (CSNK1D‐T44A), and FHM1 (CACNA1A‐S218L). Upper gastrointestinal motility was quantified by measuring gastric emptying and small intestinal transit in mutant and control animals. Gastrointestinal motility was measured at baseline and after pretreatment with 10 mg/kg nitroglycerin (NTG). Results: No significant differences were observed for gastric emptying or small intestinal transit at baseline for any of the 3 transgenic strains when compared to appropriate controls or after pretreatment with NTG when compared to vehicle. Conclusions: We detected no evidence of upper gastrointestinal dysmotility in mice that express mutations in genes linked to monogenic migraine‐relevant phenotypes. Future studies seeking to understand why humans with migraine experience delayed gastric emptying may benefit from pursuing other modifiers of gastrointestinal motility, such as epigenetic or microbiome‐related factors. [ABSTRACT FROM AUTHOR]
Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: No Gastrointestinal Dysmotility in Transgenic Mouse Models of Migraine.
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  Data: <searchLink fieldCode="AR" term="%22Sprouse+Blum%2C+Adam+S%2E%22">Sprouse Blum, Adam S.</searchLink><br /><searchLink fieldCode="AR" term="%22Lavoie%2C+Brigitte%22">Lavoie, Brigitte</searchLink><br /><searchLink fieldCode="AR" term="%22Haag%2C+Melody%22">Haag, Melody</searchLink><br /><searchLink fieldCode="AR" term="%22Mawe%2C+Seamus+M%2E%22">Mawe, Seamus M.</searchLink><br /><searchLink fieldCode="AR" term="%22Tolner%2C+Else+A%2E%22">Tolner, Else A.</searchLink><br /><searchLink fieldCode="AR" term="%22Maagdenberg%2C+Arn+M%2EJ%2EM%2E%22">Maagdenberg, Arn M.J.M.</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Shih‐Pin%22">Chen, Shih‐Pin</searchLink><br /><searchLink fieldCode="AR" term="%22Eikermann‐Haerter%2C+Katharina%22">Eikermann‐Haerter, Katharina</searchLink><br /><searchLink fieldCode="AR" term="%22Ptáček%2C+Louis%22">Ptáček, Louis</searchLink><br /><searchLink fieldCode="AR" term="%22Mawe%2C+Gary+M%2E%22">Mawe, Gary M.</searchLink><br /><searchLink fieldCode="AR" term="%22Shapiro%2C+Robert+E%2E%22">Shapiro, Robert E.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Headache%3A+The+Journal+of+Head+%26+Face+Pain%22">Headache: The Journal of Head & Face Pain</searchLink>. Feb2020, Vol. 60 Issue 2, p396-404. 9p. 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Therapeutic+use+of+nitroglycerin%22">Therapeutic use of nitroglycerin</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+diseases%22">Gastrointestinal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+motility%22">Gastrointestinal motility</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Nitroglycerin%22">Nitroglycerin</searchLink><br /><searchLink fieldCode="DE" term="%22Transgenic+animals%22">Transgenic animals</searchLink>
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  Data: Objective: To determine whether transgenic mouse models of migraine exhibit upper gastrointestinal dysmotility comparable to those observed in migraine patients. Background: There is considerable evidence supporting the comorbidity of gastrointestinal dysmotility and migraine. Gastrointestinal motility, however, has never been investigated in transgenic mouse models of migraine. Methods: Three transgenic mouse strains that express pathogenic gene mutations linked to monogenic migraine‐relevant phenotypes were studied: CADASIL (Notch3‐Tg88), FASP (CSNK1D‐T44A), and FHM1 (CACNA1A‐S218L). Upper gastrointestinal motility was quantified by measuring gastric emptying and small intestinal transit in mutant and control animals. Gastrointestinal motility was measured at baseline and after pretreatment with 10 mg/kg nitroglycerin (NTG). Results: No significant differences were observed for gastric emptying or small intestinal transit at baseline for any of the 3 transgenic strains when compared to appropriate controls or after pretreatment with NTG when compared to vehicle. Conclusions: We detected no evidence of upper gastrointestinal dysmotility in mice that express mutations in genes linked to monogenic migraine‐relevant phenotypes. Future studies seeking to understand why humans with migraine experience delayed gastric emptying may benefit from pursuing other modifiers of gastrointestinal motility, such as epigenetic or microbiome‐related factors. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/head.13724
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 396
    Subjects:
      – SubjectFull: Therapeutic use of nitroglycerin
        Type: general
      – SubjectFull: Animal experimentation
        Type: general
      – SubjectFull: Gastrointestinal diseases
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      – SubjectFull: Gastrointestinal motility
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      – SubjectFull: Mice
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      – SubjectFull: Migraine
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      – SubjectFull: Genetic mutation
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      – SubjectFull: Nitroglycerin
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      – SubjectFull: Transgenic animals
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              Text: Feb2020
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