The Neuroendocrine Effects of Venlafaxine in Healthy Subjects.
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| Title: | The Neuroendocrine Effects of Venlafaxine in Healthy Subjects. |
|---|---|
| Authors: | Daffner-Bugía, C., Laakmann, G., Voderholzer, U., Haag, C., Baghai, T., Kolmsee, S., Schröder, U., Munz, T. |
| Source: | Human Psychopharmacology: Clinical & Experimental. Jan/Feb96, Vol. 11 Issue 1, p1-9. 9p. |
| Subjects: | Neuroendocrine tumors, Venlafaxine, Neurotransmitter uptake inhibitors, Anterior pituitary gland, Hormones, Antidepressants |
| Abstract: | Venlafaxine hydrochloride represents a novel chemical class of antidepressant compounds. In preclinical studies it had monamine uptake inhibitory properties. It specifically inhibited the uptake of serotonin (5-HT) norepinephrine (NE) and dopamine (DA) in rat brain synaptosomes. Previous studies showed that various classes of psychotropic drugs with different effects on central aminergic systems exhibit distinct neuroendocrine profiles. In this study we investigated the effect of ascending doses of venlafaxine (12.5 mg, 25 mg ,50 mg,75 mg orally) on neuroendocrine function in six healthy male subjects, using a single-blind, placebo-controlled study design. After the ascending doses of venlafaxine there could be demonstrated descriptively an influence on GH, and prolactin after the higher doses of venlafaxine. The cortisol secretion was statistically significantly influenced by venlafaxine, and showed a dose dependent increase. These neuroendocrine effects of venlafaxine may be interpreted as being a result of 5-HT and NF reuptake-inhibition properties of the substance. Evidence for a DA reuptake-inhibition was not found as DA agonists lead to an inhibition of prolactin secretion. [ABSTRACT FROM AUTHOR] |
| Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 14159027 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Neuroendocrine Effects of Venlafaxine in Healthy Subjects. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Daffner-Bugía%2C+C%2E%22">Daffner-Bugía, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Laakmann%2C+G%2E%22">Laakmann, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Voderholzer%2C+U%2E%22">Voderholzer, U.</searchLink><br /><searchLink fieldCode="AR" term="%22Haag%2C+C%2E%22">Haag, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Baghai%2C+T%2E%22">Baghai, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Kolmsee%2C+S%2E%22">Kolmsee, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Schröder%2C+U%2E%22">Schröder, U.</searchLink><br /><searchLink fieldCode="AR" term="%22Munz%2C+T%2E%22">Munz, T.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Jan/Feb96, Vol. 11 Issue 1, p1-9. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neuroendocrine+tumors%22">Neuroendocrine tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Venlafaxine%22">Venlafaxine</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitter+uptake+inhibitors%22">Neurotransmitter uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Anterior+pituitary+gland%22">Anterior pituitary gland</searchLink><br /><searchLink fieldCode="DE" term="%22Hormones%22">Hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Venlafaxine hydrochloride represents a novel chemical class of antidepressant compounds. In preclinical studies it had monamine uptake inhibitory properties. It specifically inhibited the uptake of serotonin (5-HT) norepinephrine (NE) and dopamine (DA) in rat brain synaptosomes. Previous studies showed that various classes of psychotropic drugs with different effects on central aminergic systems exhibit distinct neuroendocrine profiles. In this study we investigated the effect of ascending doses of venlafaxine (12.5 mg, 25 mg ,50 mg,75 mg orally) on neuroendocrine function in six healthy male subjects, using a single-blind, placebo-controlled study design. After the ascending doses of venlafaxine there could be demonstrated descriptively an influence on GH, and prolactin after the higher doses of venlafaxine. The cortisol secretion was statistically significantly influenced by venlafaxine, and showed a dose dependent increase. These neuroendocrine effects of venlafaxine may be interpreted as being a result of 5-HT and NF reuptake-inhibition properties of the substance. Evidence for a DA reuptake-inhibition was not found as DA agonists lead to an inhibition of prolactin secretion. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/(SICI)1099-1077(199601)11:1<1::AID-HUP732>3.0.CO;2-Z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: Neuroendocrine tumors Type: general – SubjectFull: Venlafaxine Type: general – SubjectFull: Neurotransmitter uptake inhibitors Type: general – SubjectFull: Anterior pituitary gland Type: general – SubjectFull: Hormones Type: general – SubjectFull: Antidepressants Type: general Titles: – TitleFull: The Neuroendocrine Effects of Venlafaxine in Healthy Subjects. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Daffner-Bugía, C. – PersonEntity: Name: NameFull: Laakmann, G. – PersonEntity: Name: NameFull: Voderholzer, U. – PersonEntity: Name: NameFull: Haag, C. – PersonEntity: Name: NameFull: Baghai, T. – PersonEntity: Name: NameFull: Kolmsee, S. – PersonEntity: Name: NameFull: Schröder, U. – PersonEntity: Name: NameFull: Munz, T. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan/Feb96 Type: published Y: 1996 Identifiers: – Type: issn-print Value: 08856222 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: Human Psychopharmacology: Clinical & Experimental Type: main |
| ResultId | 1 |
