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The Impact of Noncavity-Distorting Intramural Fibroids on Live Birth Rate in In Vitro Fertilization Cycles: A Systematic Review and Meta-Analysis.

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Title: The Impact of Noncavity-Distorting Intramural Fibroids on Live Birth Rate in In Vitro Fertilization Cycles: A Systematic Review and Meta-Analysis.
Authors: Rikhraj, Kiran, Tan, Justin, Taskin, Omur, Albert, Arianne Y., Yong, Paul, Bedaiwy, Mohamed A.
Source: Journal of Women's Health (15409996). Feb2020, Vol. 29 Issue 2, p210-219. 10p. 1 Diagram, 1 Chart, 4 Graphs.
Subjects: Confidence intervals, Fertilization in vitro, Gynecologic surgery, Medical databases, Information storage & retrieval systems, Medical information storage & retrieval systems, Evaluation of medical care, MEDLINE, Meta-analysis, Miscarriage, Online information services, Pregnancy, Pregnancy complications, Risk assessment, Uterine fibroids, Women's health, Systematic reviews, Odds ratio, Disease complications, Disease risk factors
Abstract: What is the impact of noncavity-distorting intramural fibroids on live birth rates in in vitro fertilization (IVF) cycles? We searched Embase, MEDLINE, Google Scholar, Cochrane Library, and PUBMED from inception to May 2018. We included studies with women undergoing IVF treatment who had at least one noncavity-distorting intramural fibroid. The studies had to report one or more of the following outcomes: live birth rate as our primary outcome, and implantation rate, clinical pregnancy rate, or miscarriage rate as our secondary outcomes. We excluded studies where women also had submucosal fibroids or had undergone myomectomy. Two authors independently selected studies and extracted data. Methodological quality was assessed using Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. We included 15 studies with 5029 patients. Patients with noncavity-distorting intramural fibroids had 44% lower odds of live birth (estimated average odds ratio [OR] = 0.56, 95% confidence interval [CI] = 0.46–0.69) and 32% lower odds of clinical pregnancy (estimated average OR = 0.68, 95% CI = 0.56–0.83). Subgroup analysis of women with purely intramural fibroids showed significantly lower odds of live birth rates and clinic pregnancy rates. Analysis of prospective and retrospective studies shows that noncavity-distorting intramural fibroids have a significant adverse effect on live birth rates in women undergoing IVF. Further, well-designed prospective studies are needed to investigate whether removal of these fibroids improves IVF outcomes in this population. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: The Impact of Noncavity-Distorting Intramural Fibroids on Live Birth Rate in In Vitro Fertilization Cycles: A Systematic Review and Meta-Analysis.
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  Data: <searchLink fieldCode="AR" term="%22Rikhraj%2C+Kiran%22">Rikhraj, Kiran</searchLink><br /><searchLink fieldCode="AR" term="%22Tan%2C+Justin%22">Tan, Justin</searchLink><br /><searchLink fieldCode="AR" term="%22Taskin%2C+Omur%22">Taskin, Omur</searchLink><br /><searchLink fieldCode="AR" term="%22Albert%2C+Arianne+Y%2E%22">Albert, Arianne Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Yong%2C+Paul%22">Yong, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Bedaiwy%2C+Mohamed+A%2E%22">Bedaiwy, Mohamed A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Women's+Health+%2815409996%29%22">Journal of Women's Health (15409996)</searchLink>. Feb2020, Vol. 29 Issue 2, p210-219. 10p. 1 Diagram, 1 Chart, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Fertilization+in+vitro%22">Fertilization in vitro</searchLink><br /><searchLink fieldCode="DE" term="%22Gynecologic+surgery%22">Gynecologic surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+databases%22">Medical databases</searchLink><br /><searchLink fieldCode="DE" term="%22Information+storage+%26+retrieval+systems%22">Information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+information+storage+%26+retrieval+systems%22">Medical information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+of+medical+care%22">Evaluation of medical care</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Miscarriage%22">Miscarriage</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy+complications%22">Pregnancy complications</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Uterine+fibroids%22">Uterine fibroids</searchLink><br /><searchLink fieldCode="DE" term="%22Women's+health%22">Women's health</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: What is the impact of noncavity-distorting intramural fibroids on live birth rates in in vitro fertilization (IVF) cycles? We searched Embase, MEDLINE, Google Scholar, Cochrane Library, and PUBMED from inception to May 2018. We included studies with women undergoing IVF treatment who had at least one noncavity-distorting intramural fibroid. The studies had to report one or more of the following outcomes: live birth rate as our primary outcome, and implantation rate, clinical pregnancy rate, or miscarriage rate as our secondary outcomes. We excluded studies where women also had submucosal fibroids or had undergone myomectomy. Two authors independently selected studies and extracted data. Methodological quality was assessed using Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. We included 15 studies with 5029 patients. Patients with noncavity-distorting intramural fibroids had 44% lower odds of live birth (estimated average odds ratio [OR] = 0.56, 95% confidence interval [CI] = 0.46–0.69) and 32% lower odds of clinical pregnancy (estimated average OR = 0.68, 95% CI = 0.56–0.83). Subgroup analysis of women with purely intramural fibroids showed significantly lower odds of live birth rates and clinic pregnancy rates. Analysis of prospective and retrospective studies shows that noncavity-distorting intramural fibroids have a significant adverse effect on live birth rates in women undergoing IVF. Further, well-designed prospective studies are needed to investigate whether removal of these fibroids improves IVF outcomes in this population. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1089/jwh.2019.7813
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 210
    Subjects:
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Fertilization in vitro
        Type: general
      – SubjectFull: Gynecologic surgery
        Type: general
      – SubjectFull: Medical databases
        Type: general
      – SubjectFull: Information storage & retrieval systems
        Type: general
      – SubjectFull: Medical information storage & retrieval systems
        Type: general
      – SubjectFull: Evaluation of medical care
        Type: general
      – SubjectFull: MEDLINE
        Type: general
      – SubjectFull: Meta-analysis
        Type: general
      – SubjectFull: Miscarriage
        Type: general
      – SubjectFull: Online information services
        Type: general
      – SubjectFull: Pregnancy
        Type: general
      – SubjectFull: Pregnancy complications
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Uterine fibroids
        Type: general
      – SubjectFull: Women's health
        Type: general
      – SubjectFull: Systematic reviews
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Disease complications
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
    Titles:
      – TitleFull: The Impact of Noncavity-Distorting Intramural Fibroids on Live Birth Rate in In Vitro Fertilization Cycles: A Systematic Review and Meta-Analysis.
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            NameFull: Tan, Justin
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              M: 02
              Text: Feb2020
              Type: published
              Y: 2020
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