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Modulation by Mianserin Pretreatment of the Chronic Electroconvulsive Shock Effects on the Adrenergic System in the Cerebral Cortex of the Rat.

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Title: Modulation by Mianserin Pretreatment of the Chronic Electroconvulsive Shock Effects on the Adrenergic System in the Cerebral Cortex of the Rat.
Authors: Nalepa, Irena, Chalecka-Franaszek, Elzbieta, Vetulani, Jerzy
Source: Human Psychopharmacology: Clinical & Experimental. Jul/Aug96, Vol. 11 Issue 4, p273-282. 10p.
Subjects: Electroconvulsive therapy, Adrenergic receptors, Inositol phosphates, Cyclic adenylic acid, Protein kinase C, Psychopharmacology
Abstract: The effect of a series of electroconvulsive shock (ECS) applied after chronic administration of mianserin was tested in the rat. ECS in the group pretreated with mianserin produced a significantly larger increase in the density of α1-adrenoceptors, while its effect on β-adrenoceptor density and cyclic AMP response to noradrenaline were independent of the mianserin pretreatment. However, the cyclic AMP response to isoproterenol in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) in slices from rats receiving ECS after mianserin pretreatment was significantly higher than in the slices of rats receiving either treatment alone. While ECS did not change the responsiveness of α1-adrenoceptors as measured by IP response to noradrenaline, it significantly attenuated the responses when given after mianserin; mianserin alone significantly increased the responsiveness of α1-adrenoceptors. All treatments reduced the attenuation of IP response by protein kinase C activator TPA. The results suggest that pretreatment with mianserin may affect the ECS action of direct and PKC-modulated adrenergic response systems. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Modulation by Mianserin Pretreatment of the Chronic Electroconvulsive Shock Effects on the Adrenergic System in the Cerebral Cortex of the Rat.
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  Data: <searchLink fieldCode="AR" term="%22Nalepa%2C+Irena%22">Nalepa, Irena</searchLink><br /><searchLink fieldCode="AR" term="%22Chalecka-Franaszek%2C+Elzbieta%22">Chalecka-Franaszek, Elzbieta</searchLink><br /><searchLink fieldCode="AR" term="%22Vetulani%2C+Jerzy%22">Vetulani, Jerzy</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Jul/Aug96, Vol. 11 Issue 4, p273-282. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Electroconvulsive+therapy%22">Electroconvulsive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Adrenergic+receptors%22">Adrenergic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Inositol+phosphates%22">Inositol phosphates</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclic+adenylic+acid%22">Cyclic adenylic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinase+C%22">Protein kinase C</searchLink><br /><searchLink fieldCode="DE" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>
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  Data: The effect of a series of electroconvulsive shock (ECS) applied after chronic administration of mianserin was tested in the rat. ECS in the group pretreated with mianserin produced a significantly larger increase in the density of α1-adrenoceptors, while its effect on β-adrenoceptor density and cyclic AMP response to noradrenaline were independent of the mianserin pretreatment. However, the cyclic AMP response to isoproterenol in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) in slices from rats receiving ECS after mianserin pretreatment was significantly higher than in the slices of rats receiving either treatment alone. While ECS did not change the responsiveness of α1-adrenoceptors as measured by IP response to noradrenaline, it significantly attenuated the responses when given after mianserin; mianserin alone significantly increased the responsiveness of α1-adrenoceptors. All treatments reduced the attenuation of IP response by protein kinase C activator TPA. The results suggest that pretreatment with mianserin may affect the ECS action of direct and PKC-modulated adrenergic response systems. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/(SICI)1099-1077(199607)11:4<273::AID-HUP769>3.0.CO;2-E
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      – Code: eng
        Text: English
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      – SubjectFull: Electroconvulsive therapy
        Type: general
      – SubjectFull: Adrenergic receptors
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      – SubjectFull: Inositol phosphates
        Type: general
      – SubjectFull: Cyclic adenylic acid
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      – SubjectFull: Protein kinase C
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      – SubjectFull: Psychopharmacology
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      – TitleFull: Modulation by Mianserin Pretreatment of the Chronic Electroconvulsive Shock Effects on the Adrenergic System in the Cerebral Cortex of the Rat.
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            NameFull: Nalepa, Irena
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            NameFull: Chalecka-Franaszek, Elzbieta
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            NameFull: Vetulani, Jerzy
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            – D: 01
              M: 07
              Text: Jul/Aug96
              Type: published
              Y: 1996
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              Value: 11
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            – TitleFull: Human Psychopharmacology: Clinical & Experimental
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