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Effect of BIN1 on cardiac dysfunction and malignant arrhythmias.

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Title: Effect of BIN1 on cardiac dysfunction and malignant arrhythmias.
Authors: Jiang, Xiao‐Xin (AUTHOR), Zhu, Yan‐Rong (AUTHOR), Liu, Hong‐Ming (AUTHOR), Chen, Shao‐Liang (AUTHOR), Zhang, Dai‐Min (AUTHOR)
Source: Acta Physiologica. Mar2020, Vol. 228 Issue 3, p1-11. 11p. 4 Diagrams.
Subjects: Arrhythmia, Heart failure, Cardiac contraction, Heart diseases, Sudden death, Ryanodine receptors
Abstract: Heart failure (HF) is the end‐stage syndrome for most cardiac diseases, and the 5‐year morbidity and mortality of HF remain high. Malignant arrhythmia is the main cause of sudden death in the progression of HF. Recently, bridging integrator 1 (BIN1) was discovered as a regulator of transverse tubule function and calcium signalling in cardiomyocytes. BIN1 downregulation is linked to abnormal cardiac contraction, and it increases the possibility of malignant arrhythmias preceding HF. Because of the detectability of cardiac BIN1 in peripheral blood, BIN1 may serve as a predictor of HF and may be useful in therapy development. However, the mechanism of BIN1 downregulation in HF and how BIN1 regulates normal cardiac function under physiological conditions remain unclear. In this review, recent progress in the biological studies of BIN1‐related cardiomyocytes and the effect of cardiac dysfunction and malignant arrhythmia will be discussed. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effect of BIN1 on cardiac dysfunction and malignant arrhythmias.
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  Data: <searchLink fieldCode="AR" term="%22Jiang%2C+Xiao‐Xin%22">Jiang, Xiao‐Xin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Yan‐Rong%22">Zhu, Yan‐Rong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Hong‐Ming%22">Liu, Hong‐Ming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Shao‐Liang%22">Chen, Shao‐Liang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Dai‐Min%22">Zhang, Dai‐Min</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Mar2020, Vol. 228 Issue 3, p1-11. 11p. 4 Diagrams.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Arrhythmia%22">Arrhythmia</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+failure%22">Heart failure</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiac+contraction%22">Cardiac contraction</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+diseases%22">Heart diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Sudden+death%22">Sudden death</searchLink><br /><searchLink fieldCode="DE" term="%22Ryanodine+receptors%22">Ryanodine receptors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Heart failure (HF) is the end‐stage syndrome for most cardiac diseases, and the 5‐year morbidity and mortality of HF remain high. Malignant arrhythmia is the main cause of sudden death in the progression of HF. Recently, bridging integrator 1 (BIN1) was discovered as a regulator of transverse tubule function and calcium signalling in cardiomyocytes. BIN1 downregulation is linked to abnormal cardiac contraction, and it increases the possibility of malignant arrhythmias preceding HF. Because of the detectability of cardiac BIN1 in peripheral blood, BIN1 may serve as a predictor of HF and may be useful in therapy development. However, the mechanism of BIN1 downregulation in HF and how BIN1 regulates normal cardiac function under physiological conditions remain unclear. In this review, recent progress in the biological studies of BIN1‐related cardiomyocytes and the effect of cardiac dysfunction and malignant arrhythmia will be discussed. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/apha.13429
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      – Code: eng
        Text: English
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        PageCount: 11
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      – SubjectFull: Arrhythmia
        Type: general
      – SubjectFull: Heart failure
        Type: general
      – SubjectFull: Cardiac contraction
        Type: general
      – SubjectFull: Heart diseases
        Type: general
      – SubjectFull: Sudden death
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      – SubjectFull: Ryanodine receptors
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    Titles:
      – TitleFull: Effect of BIN1 on cardiac dysfunction and malignant arrhythmias.
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            NameFull: Zhu, Yan‐Rong
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            NameFull: Chen, Shao‐Liang
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            NameFull: Zhang, Dai‐Min
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              Text: Mar2020
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              Y: 2020
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