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Default mode network connectivity change corresponds to ketamine's delayed glutamatergic effects.

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Title: Default mode network connectivity change corresponds to ketamine's delayed glutamatergic effects.
Authors: Li, Meng (AUTHOR), Woelfer, Marie (AUTHOR), Colic, Lejla (AUTHOR), Safron, Adam (AUTHOR), Chang, Catie (AUTHOR), Heinze, Hans-Jochen (AUTHOR), Speck, Oliver (AUTHOR), Mayberg, Helen S. (AUTHOR), Biswal, Bharat B. (AUTHOR), Salvadore, Giacomo (AUTHOR), Fejtova, Anna (AUTHOR), Walter, Martin (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Mar2020, Vol. 270 Issue 2, p207-216. 10p. 3 Charts, 2 Graphs.
Subjects: Ketamine, Cingulate cortex, Brain metabolism, Nuclear magnetic resonance spectroscopy, Prefrontal cortex, Default mode network
Abstract: Ketamine exerts rapid antidepressant effects peaking 24 h after a single infusion, which have been suggested to be reflected by both reduced functional connectivity (FC) within default mode network (DMN) and altered glutamatergic levels in the perigenual anterior cingulate cortex (pgACC) at 24 h. Understanding the interrelation and time point specificity of ketamine-induced changes of brain circuitry and metabolism is thus key to future therapeutic developments. We investigated the correlation of late glutamatergic changes with FC changes seeded from the posterior cingulate cortex (PCC) and tested the prediction of the latter by acute fractional amplitude of low-frequency fluctuations (fALFF). In a double-blind, randomized, placebo-controlled study of 61 healthy subjects, we compared effects of subanesthetic ketamine infusion (0.5 mg/kg over 40 min) on resting-state fMRI and MR-Spectroscopy at 7 T 1 h and 24 h post-infusion. FC decrease between PCC and dorsomedial prefrontal cortex (dmPFC) was found at 24 h post-infusion (but not 1 h) and this FC decrease correlated with glutamatergic changes at 24 h in pgACC. Acute increase in fALFF was found in ventral PCC at 1 h which was not observed at 24 h and inversely correlated with the reduced dPCC FC towards the dmPFC at 24 h. The correlation of metabolic and functional markers of delayed ketamine effects and their temporal specificity suggest a potential mechanistic relationship between glutamatergic modulation and reconfiguration of brain regions belonging to the DMN. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Default mode network connectivity change corresponds to ketamine's delayed glutamatergic effects.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Meng%22">Li, Meng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Woelfer%2C+Marie%22">Woelfer, Marie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Colic%2C+Lejla%22">Colic, Lejla</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Safron%2C+Adam%22">Safron, Adam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Catie%22">Chang, Catie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heinze%2C+Hans-Jochen%22">Heinze, Hans-Jochen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Speck%2C+Oliver%22">Speck, Oliver</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mayberg%2C+Helen+S%2E%22">Mayberg, Helen S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Biswal%2C+Bharat+B%2E%22">Biswal, Bharat B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salvadore%2C+Giacomo%22">Salvadore, Giacomo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fejtova%2C+Anna%22">Fejtova, Anna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Walter%2C+Martin%22">Walter, Martin</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Mar2020, Vol. 270 Issue 2, p207-216. 10p. 3 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Ketamine%22">Ketamine</searchLink><br /><searchLink fieldCode="DE" term="%22Cingulate+cortex%22">Cingulate cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+metabolism%22">Brain metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance+spectroscopy%22">Nuclear magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Default+mode+network%22">Default mode network</searchLink>
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  Label: Abstract
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  Data: Ketamine exerts rapid antidepressant effects peaking 24 h after a single infusion, which have been suggested to be reflected by both reduced functional connectivity (FC) within default mode network (DMN) and altered glutamatergic levels in the perigenual anterior cingulate cortex (pgACC) at 24 h. Understanding the interrelation and time point specificity of ketamine-induced changes of brain circuitry and metabolism is thus key to future therapeutic developments. We investigated the correlation of late glutamatergic changes with FC changes seeded from the posterior cingulate cortex (PCC) and tested the prediction of the latter by acute fractional amplitude of low-frequency fluctuations (fALFF). In a double-blind, randomized, placebo-controlled study of 61 healthy subjects, we compared effects of subanesthetic ketamine infusion (0.5 mg/kg over 40 min) on resting-state fMRI and MR-Spectroscopy at 7 T 1 h and 24 h post-infusion. FC decrease between PCC and dorsomedial prefrontal cortex (dmPFC) was found at 24 h post-infusion (but not 1 h) and this FC decrease correlated with glutamatergic changes at 24 h in pgACC. Acute increase in fALFF was found in ventral PCC at 1 h which was not observed at 24 h and inversely correlated with the reduced dPCC FC towards the dmPFC at 24 h. The correlation of metabolic and functional markers of delayed ketamine effects and their temporal specificity suggest a potential mechanistic relationship between glutamatergic modulation and reconfiguration of brain regions belonging to the DMN. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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