View in EDS HTML Full Text PDF Full Text

Age effects on basic symptoms in the community: A route to gain new insight into the neurodevelopment of psychosis?

Saved in:
Bibliographic Details
Title: Age effects on basic symptoms in the community: A route to gain new insight into the neurodevelopment of psychosis?
Authors: Schultze-Lutter, Frauke (AUTHOR), Ruhrmann, Stephan (AUTHOR), Michel, Chantal (AUTHOR), Kindler, Jochen (AUTHOR), Schimmelmann, Benno G. (AUTHOR), Schmidt, Stefanie J. (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Apr2020, Vol. 270 Issue 3, p311-324. 14p. 1 Diagram, 5 Charts, 1 Graph.
Subjects: Neural development, Psychoses, Age, Pathology, Mental illness
Geographic Terms: Bern (Switzerland)
Abstract: Reports of limited clinical significance of attenuated psychotic symptoms before age 15/16 indicate an important role of neurodevelopment in the early detection of psychoses. Therefore, we examined if age also exerts an influence on the prevalence and clinical significance of the 14 cognitive and perceptive basic symptoms (BS) used in psychosis-risk criteria and conceptualized as the most direct self-experienced expression of neurobiological aberrations. A random representative general population sample of the Swiss canton Bern (N = 689, age 8–40 years, 06/2011–05/2014) was interviewed for BS, psychosocial functioning, and current mental disorder. BS were reported by 18% of participants, mainly cognitive BS (15%). In regression analyses, age affected perceptive and cognitive BS differently, indicating an age threshold for perceptive BS in late adolescence (around age 18) and for cognitive BS in young adulthood (early twenties)—with higher prevalence, but a lesser association with functional deficits and the presence of mental disorder in the below-threshold groups. Thereby, interaction effects between age and BS on functioning and mental disorder were commonly stronger than individual effects of age and BS. Indicating support of the proposed "substrate-closeness" of BS, differential age effects of perceptual and cognitive BS seem to follow normal brain maturation processes, in which they might occur as infrequent and temporary non-pathological disturbances. Their persistence or occurrence after conclusion of main brain maturation processes, however, might signify aberrant maturation or neurodegenerative processes. Thus, BS might provide important insight into the pathogenesis of psychosis and into differential neuroprotective or anti-inflammatory targets. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 142224837
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Age effects on basic symptoms in the community: A route to gain new insight into the neurodevelopment of psychosis?
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Schultze-Lutter%2C+Frauke%22">Schultze-Lutter, Frauke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ruhrmann%2C+Stephan%22">Ruhrmann, Stephan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michel%2C+Chantal%22">Michel, Chantal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kindler%2C+Jochen%22">Kindler, Jochen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schimmelmann%2C+Benno+G%2E%22">Schimmelmann, Benno G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmidt%2C+Stefanie+J%2E%22">Schmidt, Stefanie J.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Apr2020, Vol. 270 Issue 3, p311-324. 14p. 1 Diagram, 5 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Age%22">Age</searchLink><br /><searchLink fieldCode="DE" term="%22Pathology%22">Pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Bern+%28Switzerland%29%22">Bern (Switzerland)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Reports of limited clinical significance of attenuated psychotic symptoms before age 15/16 indicate an important role of neurodevelopment in the early detection of psychoses. Therefore, we examined if age also exerts an influence on the prevalence and clinical significance of the 14 cognitive and perceptive basic symptoms (BS) used in psychosis-risk criteria and conceptualized as the most direct self-experienced expression of neurobiological aberrations. A random representative general population sample of the Swiss canton Bern (N = 689, age 8–40 years, 06/2011–05/2014) was interviewed for BS, psychosocial functioning, and current mental disorder. BS were reported by 18% of participants, mainly cognitive BS (15%). In regression analyses, age affected perceptive and cognitive BS differently, indicating an age threshold for perceptive BS in late adolescence (around age 18) and for cognitive BS in young adulthood (early twenties)—with higher prevalence, but a lesser association with functional deficits and the presence of mental disorder in the below-threshold groups. Thereby, interaction effects between age and BS on functioning and mental disorder were commonly stronger than individual effects of age and BS. Indicating support of the proposed "substrate-closeness" of BS, differential age effects of perceptual and cognitive BS seem to follow normal brain maturation processes, in which they might occur as infrequent and temporary non-pathological disturbances. Their persistence or occurrence after conclusion of main brain maturation processes, however, might signify aberrant maturation or neurodegenerative processes. Thus, BS might provide important insight into the pathogenesis of psychosis and into differential neuroprotective or anti-inflammatory targets. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=142224837
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-018-0949-4
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 311
    Subjects:
      – SubjectFull: Neural development
        Type: general
      – SubjectFull: Psychoses
        Type: general
      – SubjectFull: Age
        Type: general
      – SubjectFull: Pathology
        Type: general
      – SubjectFull: Mental illness
        Type: general
      – SubjectFull: Bern (Switzerland)
        Type: general
    Titles:
      – TitleFull: Age effects on basic symptoms in the community: A route to gain new insight into the neurodevelopment of psychosis?
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Schultze-Lutter, Frauke
      – PersonEntity:
          Name:
            NameFull: Ruhrmann, Stephan
      – PersonEntity:
          Name:
            NameFull: Michel, Chantal
      – PersonEntity:
          Name:
            NameFull: Kindler, Jochen
      – PersonEntity:
          Name:
            NameFull: Schimmelmann, Benno G.
      – PersonEntity:
          Name:
            NameFull: Schmidt, Stefanie J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 270
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1