Sodium retention by uPA‐plasmin‐ENaC in nephrotic syndrome—Authors reply.

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Title: Sodium retention by uPA‐plasmin‐ENaC in nephrotic syndrome—Authors reply.
Authors: Hinrichs, Gitte R. (AUTHOR), Weyer, Kathrin (AUTHOR), Friis, Ulla G. (AUTHOR), Svenningsen, Per (AUTHOR), Lund, Ida Katrine (AUTHOR), Nielsen, Rikke (AUTHOR), Mollet, Géraldine (AUTHOR), Antignac, Corinne (AUTHOR), Bistrup, Claus (AUTHOR), Jensen, Boye L. (AUTHOR), Birn, Henrik (AUTHOR)
Source: Acta Physiologica. Apr2020, Vol. 228 Issue 4, p1-3. 3p.
Subjects: Nephrotic syndrome, Plasminogen activators, Serine proteinases, Brugada syndrome, Serum albumin
Abstract: Sodium retention by uPA-plasmin-ENaC in nephrotic syndrome - Authors reply There is a great interest in exploring the mechanisms of oedema in nephrotic syndrome (NS) as evidenced by two parallel studies published in Acta Physiologica.[[1]] This has generated an editorial comment[3] which we respond to by this rebuttal. This seminal observation indicates that serine protease activity contributes to nephrotic sodium retention in mouse NS [8]; however, the importance of the individual protease(s) remains to be clarified. [Extracted from the article]
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Database: Psychology and Behavioral Sciences Collection
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Abstract:Sodium retention by uPA-plasmin-ENaC in nephrotic syndrome - Authors reply There is a great interest in exploring the mechanisms of oedema in nephrotic syndrome (NS) as evidenced by two parallel studies published in Acta Physiologica.[[1]] This has generated an editorial comment[3] which we respond to by this rebuttal. This seminal observation indicates that serine protease activity contributes to nephrotic sodium retention in mouse NS [8]; however, the importance of the individual protease(s) remains to be clarified. [Extracted from the article]
ISSN:17481708
DOI:10.1111/apha.13432