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Urinalysis in patients with neuromyelitis optica spectrum disorder.

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Title: Urinalysis in patients with neuromyelitis optica spectrum disorder.
Authors: Chen, Z. G. (AUTHOR), Huang, J. (AUTHOR), Fan, R. (AUTHOR), Weng, R. H. (AUTHOR), Shinohara, R. T. (AUTHOR), Landis, J. R. (AUTHOR), Chen, Y. (AUTHOR), Jiang, Y. (AUTHOR)
Source: European Journal of Neurology. Apr2020, Vol. 27 Issue 4, p619-625. 7p. 1 Diagram, 4 Charts, 1 Graph.
Subjects: Neuromyelitis optica, Specific gravity, Urinalysis, Central nervous system, Immunoglobulin G
Abstract: Background and purpose: Increasing evidence has demonstrated that aquaporin‐4 (AQP4) immunoglobulin G causes damage to the kidney in neuromyelitis optica spectrum disorder (NMOSD). However, changes in urinalysis in NMOSD have not been investigated thus far. Our objective was to evaluate the changes in urinalysis in NMOSD patients. Methods: Case data were collected from 44 patients with AQP4 antibody‐positive NMOSD, 53 patients with multiple sclerosis (MS) and 79 age‐ and sex‐matched healthy controls. Analyses of early morning urine and 24‐h urine samples comparing NMOSD with MS patients were conducted. Results: In the acute phase, urine pH levels (P < 0.001) and urine specific gravity levels (P < 0.001) from NMOSD patients were significantly higher and lower, respectively, than for MS patients. 24‐h urine sodium and 24‐h urine volume from NMOSD patients were significantly higher than for MS patients (both P = 0.001). A 24‐h urine volume higher than 2500 ml (odds ratio 11.7, 95% confidence interval 1.863–73.066) and a 24‐h urine sodium higher than 200 mmol (odds ratio 16.0, 95% confidence interval 2.122–120.648) are more likely to occur in NMOSD patients in the acute phase than in MS patients. Conclusions: The urinalysis results were significantly different between NMOSD patients and MS patients. The pathophysiological changes in AQP4 antibody‐positive NMOSD patients were not limited to the central nervous system. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Urinalysis in patients with neuromyelitis optica spectrum disorder.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Z%2E+G%2E%22&quot;&gt;Chen, Z. G.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Huang%2C+J%2E%22&quot;&gt;Huang, J.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fan%2C+R%2E%22&quot;&gt;Fan, R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Weng%2C+R%2E+H%2E%22&quot;&gt;Weng, R. H.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shinohara%2C+R%2E+T%2E%22&quot;&gt;Shinohara, R. T.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Landis%2C+J%2E+R%2E%22&quot;&gt;Landis, J. R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Y%2E%22&quot;&gt;Chen, Y.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jiang%2C+Y%2E%22&quot;&gt;Jiang, Y.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Apr2020, Vol. 27 Issue 4, p619-625. 7p. 1 Diagram, 4 Charts, 1 Graph.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neuromyelitis+optica%22&quot;&gt;Neuromyelitis optica&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Specific+gravity%22&quot;&gt;Specific gravity&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Urinalysis%22&quot;&gt;Urinalysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Central+nervous+system%22&quot;&gt;Central nervous system&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Immunoglobulin+G%22&quot;&gt;Immunoglobulin G&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
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  Data: Background and purpose: Increasing evidence has demonstrated that aquaporin‐4 (AQP4) immunoglobulin G causes damage to the kidney in neuromyelitis optica spectrum disorder (NMOSD). However, changes in urinalysis in NMOSD have not been investigated thus far. Our objective was to evaluate the changes in urinalysis in NMOSD patients. Methods: Case data were collected from 44 patients with AQP4 antibody‐positive NMOSD, 53 patients with multiple sclerosis (MS) and 79 age‐ and sex‐matched healthy controls. Analyses of early morning urine and 24‐h urine samples comparing NMOSD with MS patients were conducted. Results: In the acute phase, urine pH levels (P &lt; 0.001) and urine specific gravity levels (P &lt; 0.001) from NMOSD patients were significantly higher and lower, respectively, than for MS patients. 24‐h urine sodium and 24‐h urine volume from NMOSD patients were significantly higher than for MS patients (both P = 0.001). A 24‐h urine volume higher than 2500 ml (odds ratio 11.7, 95% confidence interval 1.863–73.066) and a 24‐h urine sodium higher than 200 mmol (odds ratio 16.0, 95% confidence interval 2.122–120.648) are more likely to occur in NMOSD patients in the acute phase than in MS patients. Conclusions: The urinalysis results were significantly different between NMOSD patients and MS patients. The pathophysiological changes in AQP4 antibody‐positive NMOSD patients were not limited to the central nervous system. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/ene.14128
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 619
    Subjects:
      – SubjectFull: Neuromyelitis optica
        Type: general
      – SubjectFull: Specific gravity
        Type: general
      – SubjectFull: Urinalysis
        Type: general
      – SubjectFull: Central nervous system
        Type: general
      – SubjectFull: Immunoglobulin G
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      – TitleFull: Urinalysis in patients with neuromyelitis optica spectrum disorder.
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              Text: Apr2020
              Type: published
              Y: 2020
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