View in EDS HTML Full Text PDF Full Text

Affective lability in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.

Saved in:
Bibliographic Details
Title: Affective lability in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.
Authors: Zwicker, Alyson, Drobinin, Vladislav, MacKenzie, Lynn E., Howes Vallis, Emily, Patterson, Victoria C., Cumby, Jill, Propper, Lukas, Abidi, Sabina, Bagnell, Alexa, Pavlova, Barbara, Alda, Martin, Uher, Rudolf
Source: European Child & Adolescent Psychiatry. Apr2020, Vol. 29 Issue 4, p445-451. 7p. 2 Charts, 1 Graph.
Subjects: Affective disorders, Children of people with mental illness, Confidence intervals, Mental depression, Longitudinal method, Bipolar disorder, Regression analysis, Schizophrenia, Self-evaluation, Descriptive statistics
Abstract: Affective lability, defined as the propensity to experience excessive and unpredictable changes in mood, has been proposed as a potential transdiagnostic predictor of major mood and psychotic disorders. A parental diagnosis of bipolar disorder has been associated with increased affective lability in offspring. However, the association between affective lability and family history of other mood and psychotic disorders has not been examined. We measured affective lability using the self- and parent-reported Children's Affective Lability Scale in a cohort of 320 youth aged 6–17 years, including 137 offspring of a parent with major depressive disorder, 68 offspring of a parent with bipolar disorder, 24 offspring of a parent with schizophrenia, and 91 offspring of control parents. We tested differences in affective lability between groups using mixed-effects linear regression. Offspring of a parent with major depressive disorder (β = 0.46, 95% CI 0.17–0.76, p = 0.002) or bipolar disorder (β = 0.47, 95% CI 0.12–0.81, p = 0.008) had significantly higher affective lability scores than control offspring. Affective lability did not differ significantly between offspring of a parent with schizophrenia and offspring of control parents. Our results suggest that elevated affective lability during childhood is a marker of familial risk for mood disorders. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 142453064
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Affective lability in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zwicker%2C+Alyson%22">Zwicker, Alyson</searchLink><br /><searchLink fieldCode="AR" term="%22Drobinin%2C+Vladislav%22">Drobinin, Vladislav</searchLink><br /><searchLink fieldCode="AR" term="%22MacKenzie%2C+Lynn+E%2E%22">MacKenzie, Lynn E.</searchLink><br /><searchLink fieldCode="AR" term="%22Howes+Vallis%2C+Emily%22">Howes Vallis, Emily</searchLink><br /><searchLink fieldCode="AR" term="%22Patterson%2C+Victoria+C%2E%22">Patterson, Victoria C.</searchLink><br /><searchLink fieldCode="AR" term="%22Cumby%2C+Jill%22">Cumby, Jill</searchLink><br /><searchLink fieldCode="AR" term="%22Propper%2C+Lukas%22">Propper, Lukas</searchLink><br /><searchLink fieldCode="AR" term="%22Abidi%2C+Sabina%22">Abidi, Sabina</searchLink><br /><searchLink fieldCode="AR" term="%22Bagnell%2C+Alexa%22">Bagnell, Alexa</searchLink><br /><searchLink fieldCode="AR" term="%22Pavlova%2C+Barbara%22">Pavlova, Barbara</searchLink><br /><searchLink fieldCode="AR" term="%22Alda%2C+Martin%22">Alda, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Uher%2C+Rudolf%22">Uher, Rudolf</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Apr2020, Vol. 29 Issue 4, p445-451. 7p. 2 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Children+of+people+with+mental+illness%22">Children of people with mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Self-evaluation%22">Self-evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Affective lability, defined as the propensity to experience excessive and unpredictable changes in mood, has been proposed as a potential transdiagnostic predictor of major mood and psychotic disorders. A parental diagnosis of bipolar disorder has been associated with increased affective lability in offspring. However, the association between affective lability and family history of other mood and psychotic disorders has not been examined. We measured affective lability using the self- and parent-reported Children's Affective Lability Scale in a cohort of 320 youth aged 6–17 years, including 137 offspring of a parent with major depressive disorder, 68 offspring of a parent with bipolar disorder, 24 offspring of a parent with schizophrenia, and 91 offspring of control parents. We tested differences in affective lability between groups using mixed-effects linear regression. Offspring of a parent with major depressive disorder (β = 0.46, 95% CI 0.17–0.76, p = 0.002) or bipolar disorder (β = 0.47, 95% CI 0.12–0.81, p = 0.008) had significantly higher affective lability scores than control offspring. Affective lability did not differ significantly between offspring of a parent with schizophrenia and offspring of control parents. Our results suggest that elevated affective lability during childhood is a marker of familial risk for mood disorders. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=142453064
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00787-019-01355-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 445
    Subjects:
      – SubjectFull: Affective disorders
        Type: general
      – SubjectFull: Children of people with mental illness
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Self-evaluation
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
    Titles:
      – TitleFull: Affective lability in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zwicker, Alyson
      – PersonEntity:
          Name:
            NameFull: Drobinin, Vladislav
      – PersonEntity:
          Name:
            NameFull: MacKenzie, Lynn E.
      – PersonEntity:
          Name:
            NameFull: Howes Vallis, Emily
      – PersonEntity:
          Name:
            NameFull: Patterson, Victoria C.
      – PersonEntity:
          Name:
            NameFull: Cumby, Jill
      – PersonEntity:
          Name:
            NameFull: Propper, Lukas
      – PersonEntity:
          Name:
            NameFull: Abidi, Sabina
      – PersonEntity:
          Name:
            NameFull: Bagnell, Alexa
      – PersonEntity:
          Name:
            NameFull: Pavlova, Barbara
      – PersonEntity:
          Name:
            NameFull: Alda, Martin
      – PersonEntity:
          Name:
            NameFull: Uher, Rudolf
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 10188827
          Numbering:
            – Type: volume
              Value: 29
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: European Child & Adolescent Psychiatry
              Type: main
ResultId 1