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Effects of psychological treatment of mental health problems in pregnant women to protect their offspring: randomised controlled trial.

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Title: Effects of psychological treatment of mental health problems in pregnant women to protect their offspring: randomised controlled trial.
Authors: Burger, Huibert (AUTHOR), Verbeek, Tjitte (AUTHOR), Aris-Meijer, Judith L. (AUTHOR), Beijers, Chantal (AUTHOR), Mol, Ben W. (AUTHOR), Hollon, Steven D. (AUTHOR), Ormel, Johan (AUTHOR), van Pampus, Mariëlle G. (AUTHOR), Bockting, Claudi L.H. (AUTHOR)
Source: British Journal of Psychiatry. Apr2020, Vol. 216 Issue 4, p182-188. 7p.
Subjects: Prenatal depression, Mental health services, Maternal health, Child Behavior Checklist, Treatment effectiveness, Motor ability in children, Anxiety disorders treatment, Research, Child development, Research methodology, Evaluation research, Medical cooperation, Prenatal exposure delayed effects, Comparative studies, Mental depression, Pregnancy complications
Geographic Terms: Netherlands
Abstract: Background: Perinatal depression and anxiety are associated with unfavourable child outcomes.Aims: To assess among women with antenatal depression or anxiety the effectiveness of prenatally initiated cognitive-behavioural therapy (CBT) on mother and child compared with care as usual (CAU). Trial registration: Netherlands Trial Register number NTR2242.Method: Pregnant women (n = 282) who screened positive for symptoms of depression and/or anxiety were randomised to either CBT (n = 140) or CAU (n = 142). The primary outcome was child behavioural and emotional problems at age 18 months, assessed using the Child Behavior Checklist (CBCL). Secondary outcomes were maternal symptoms during and up to 18 months after pregnancy, neonatal outcomes, mother-infant bonding and child cognitive and motor development at age 18 months.Results: In total, 94 (67%) women in the CBT group and 98 (69%) in the CAU group completed the study. The mean CBCL Total Problems score was non-significantly higher in the CBT group than in the CAU group (mean difference: 1.38 (95% CI -1.82 to 4.57); t = 0.85, P = 0.399). No effects on secondary outcomes were observed except for depression and anxiety, which were higher in the CBT group than in the CAU group at mid-pregnancy. A post hoc analysis of the 98 women with anxiety disorders showed lower infant gestational age at delivery in the CBT than in the CAU group.Conclusions: Prenatally initiated CBT did not improve maternal symptoms or child outcomes among non-help-seeking women with antenatal depression or anxiety. Our findings are not in line with present recommendations for universal screening and treatment for antenatal depression or anxiety, and future work may include the relevance of baseline help-seeking. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of psychological treatment of mental health problems in pregnant women to protect their offspring: randomised controlled trial.
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  Data: <searchLink fieldCode="AR" term="%22Burger%2C+Huibert%22">Burger, Huibert</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verbeek%2C+Tjitte%22">Verbeek, Tjitte</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aris-Meijer%2C+Judith+L%2E%22">Aris-Meijer, Judith L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beijers%2C+Chantal%22">Beijers, Chantal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mol%2C+Ben+W%2E%22">Mol, Ben W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hollon%2C+Steven+D%2E%22">Hollon, Steven D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ormel%2C+Johan%22">Ormel, Johan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Pampus%2C+Mariëlle+G%2E%22">van Pampus, Mariëlle G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bockting%2C+Claudi+L%2EH%2E%22">Bockting, Claudi L.H.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Apr2020, Vol. 216 Issue 4, p182-188. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Prenatal+depression%22">Prenatal depression</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health+services%22">Mental health services</searchLink><br /><searchLink fieldCode="DE" term="%22Maternal+health%22">Maternal health</searchLink><br /><searchLink fieldCode="DE" term="%22Child+Behavior+Checklist%22">Child Behavior Checklist</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+ability+in+children%22">Motor ability in children</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders+treatment%22">Anxiety disorders treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Child+development%22">Child development</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+exposure+delayed+effects%22">Prenatal exposure delayed effects</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy+complications%22">Pregnancy complications</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Netherlands%22">Netherlands</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>Perinatal depression and anxiety are associated with unfavourable child outcomes.<bold>Aims: </bold>To assess among women with antenatal depression or anxiety the effectiveness of prenatally initiated cognitive-behavioural therapy (CBT) on mother and child compared with care as usual (CAU). Trial registration: Netherlands Trial Register number NTR2242.<bold>Method: </bold>Pregnant women (n = 282) who screened positive for symptoms of depression and/or anxiety were randomised to either CBT (n = 140) or CAU (n = 142). The primary outcome was child behavioural and emotional problems at age 18 months, assessed using the Child Behavior Checklist (CBCL). Secondary outcomes were maternal symptoms during and up to 18 months after pregnancy, neonatal outcomes, mother-infant bonding and child cognitive and motor development at age 18 months.<bold>Results: </bold>In total, 94 (67%) women in the CBT group and 98 (69%) in the CAU group completed the study. The mean CBCL Total Problems score was non-significantly higher in the CBT group than in the CAU group (mean difference: 1.38 (95% CI -1.82 to 4.57); t = 0.85, P = 0.399). No effects on secondary outcomes were observed except for depression and anxiety, which were higher in the CBT group than in the CAU group at mid-pregnancy. A post hoc analysis of the 98 women with anxiety disorders showed lower infant gestational age at delivery in the CBT than in the CAU group.<bold>Conclusions: </bold>Prenatally initiated CBT did not improve maternal symptoms or child outcomes among non-help-seeking women with antenatal depression or anxiety. Our findings are not in line with present recommendations for universal screening and treatment for antenatal depression or anxiety, and future work may include the relevance of baseline help-seeking. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=142473056
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1192/bjp.2019.260
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 182
    Subjects:
      – SubjectFull: Prenatal depression
        Type: general
      – SubjectFull: Mental health services
        Type: general
      – SubjectFull: Maternal health
        Type: general
      – SubjectFull: Child Behavior Checklist
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Motor ability in children
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      – SubjectFull: Anxiety disorders treatment
        Type: general
      – SubjectFull: Research
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      – SubjectFull: Child development
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      – SubjectFull: Research methodology
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      – SubjectFull: Evaluation research
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      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Prenatal exposure delayed effects
        Type: general
      – SubjectFull: Comparative studies
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      – SubjectFull: Mental depression
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      – SubjectFull: Pregnancy complications
        Type: general
      – SubjectFull: Netherlands
        Type: general
    Titles:
      – TitleFull: Effects of psychological treatment of mental health problems in pregnant women to protect their offspring: randomised controlled trial.
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              Text: Apr2020
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