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Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring.

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Title: Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring.
Authors: Ellis, Alexandra S. (AUTHOR), Toussaint, Andre B. (AUTHOR), Knouse, Melissa C. (AUTHOR), Thomas, Arthur S. (AUTHOR), Bongiovanni, Angela R. (AUTHOR), Mayberry, Hannah L. (AUTHOR), Bhakta, Shivam (AUTHOR), Peer, Kyle (AUTHOR), Bangasser, Debra A. (AUTHOR), Wimmer, Mathieu E. (AUTHOR)
Source: Psychopharmacology. Apr2020, Vol. 237 Issue 4, p1209-1221. 13p. 2 Charts, 5 Graphs.
Subjects: Pharmacology, Morphine, Memory testing, Memory, Defensiveness (Psychology), Conception, Glucocorticoids, Maternally acquired immunity
Abstract: Rationale: Parental drug use around or before conception can have adverse consequences for offspring. Historically, this research has focused on the effects of maternal substance use on future generations but less is known about the influence of the paternal lineage. This study focused on the impact of chronic paternal morphine exposure prior to conception on behavioral outcomes in male and female progeny. Objectives: This study sought to investigate the impact of paternal morphine self-administration on anxiety-like behavior, the stress response, and memory in male and female offspring. Methods: Adult, drug-naïve male and female progeny of morphine-treated sires and controls were evaluated for anxiety-like behavior using defensive probe burying and novelty-induced hypophagia paradigms. Hypothalamic-pituitary-adrenal (HPA) axis function was assessed by measuring plasma corticosterone levels following a restraint stressor in male and female progeny. Memory was probed using a battery of tests including object location memory, novel object recognition, and contextual fear conditioning. Results: Paternal morphine exposure did not alter anxiety-like behavior or stress-induced HPA axis activation in male or female offspring. Morphine-sired male and female offspring showed intact hippocampus-dependent memory: they performed normally on the long-term fear conditioning and object location memory tests. In contrast, paternal morphine exposure selectively disrupted novel object recognition in female, but not male, progeny. Conclusions: Our findings demonstrate that paternal morphine taking produces sex-specific and selective impairments in object recognition memory while leaving hippocampal function largely intact. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring.
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  Data: <searchLink fieldCode="AR" term="%22Ellis%2C+Alexandra+S%2E%22">Ellis, Alexandra S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Toussaint%2C+Andre+B%2E%22">Toussaint, Andre B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Knouse%2C+Melissa+C%2E%22">Knouse, Melissa C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomas%2C+Arthur+S%2E%22">Thomas, Arthur S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bongiovanni%2C+Angela+R%2E%22">Bongiovanni, Angela R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mayberry%2C+Hannah+L%2E%22">Mayberry, Hannah L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bhakta%2C+Shivam%22">Bhakta, Shivam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peer%2C+Kyle%22">Peer, Kyle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bangasser%2C+Debra+A%2E%22">Bangasser, Debra A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wimmer%2C+Mathieu+E%2E%22">Wimmer, Mathieu E.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Apr2020, Vol. 237 Issue 4, p1209-1221. 13p. 2 Charts, 5 Graphs.
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  Data: Rationale: Parental drug use around or before conception can have adverse consequences for offspring. Historically, this research has focused on the effects of maternal substance use on future generations but less is known about the influence of the paternal lineage. This study focused on the impact of chronic paternal morphine exposure prior to conception on behavioral outcomes in male and female progeny. Objectives: This study sought to investigate the impact of paternal morphine self-administration on anxiety-like behavior, the stress response, and memory in male and female offspring. Methods: Adult, drug-naïve male and female progeny of morphine-treated sires and controls were evaluated for anxiety-like behavior using defensive probe burying and novelty-induced hypophagia paradigms. Hypothalamic-pituitary-adrenal (HPA) axis function was assessed by measuring plasma corticosterone levels following a restraint stressor in male and female progeny. Memory was probed using a battery of tests including object location memory, novel object recognition, and contextual fear conditioning. Results: Paternal morphine exposure did not alter anxiety-like behavior or stress-induced HPA axis activation in male or female offspring. Morphine-sired male and female offspring showed intact hippocampus-dependent memory: they performed normally on the long-term fear conditioning and object location memory tests. In contrast, paternal morphine exposure selectively disrupted novel object recognition in female, but not male, progeny. Conclusions: Our findings demonstrate that paternal morphine taking produces sex-specific and selective impairments in object recognition memory while leaving hippocampal function largely intact. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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