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Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts.

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Title: Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts.
Authors: Thesing, C. S. (AUTHOR), Lok, A. (AUTHOR), Milaneschi, Y. (AUTHOR), Assies, J. (AUTHOR), Bockting, C. L. H. (AUTHOR), Figueroa, C. A. (AUTHOR), Giltay, E. J. (AUTHOR), Penninx, B. W. J. H. (AUTHOR), Ruhé, H. G. (AUTHOR), Schene, A. H. (AUTHOR), Bot, M. (AUTHOR), Mocking, R. J. T. (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Apr2020, Vol. 141 Issue 4, p362-373. 12p. 1 Chart, 2 Graphs.
Subjects: Mental depression, Fatty acids, Unsaturated fatty acids
Geographic Terms: Netherlands
Abstract: Objective: Omega‐3 (n‐3) and omega‐6 (n‐6) polyunsaturated fatty acid (PUFA) alterations in patients with major depressive disorder (MDD) have been shown to persist after remission. Whether these alterations are risk factors for MDD recurrence remains unknown. Here, we examined whether fatty acids predict time until MDD recurrence in remitted MDD patients. Methods: Data were used from remitted MDD patients of the Netherlands Study of Depression and Anxiety (n = 356) and the Depression Evaluation Longitudinal Therapy Assessment studies (n = 118). Associations of FAs with time until MDD recurrence up to 8‐year follow‐up were analyzed using Cox regression analyses. Study‐specific estimates were pooled using mega‐ and meta‐analysis techniques. Results: 27.5% (NESDA) and 56.8% (DELTA) participants had an MDD recurrence. Pooled results showed that no FA was significantly associated with time until MDD recurrence (n‐3 PUFAs: hazard ratio (HR) = 1.17, 95% confidence interval (CI) = 0.98–1.41, P = 0.082; n‐6 PUFAs: HR = 1.08, 95% CI = 0.84–1.38, P = 0.55). Conclusion: In remitted MDD patients, circulating PUFAs were not associated with prospective risk of MDD recurrence. Consequently, circulating PUFAs are unlikely to reflect a vulnerability marker for recurrence, so correcting n‐3 PUFA 'deficits' through supplementation does not seem a promising option to prevent MDD recurrence. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts.
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  Data: <searchLink fieldCode="AR" term="%22Thesing%2C+C%2E+S%2E%22">Thesing, C. S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lok%2C+A%2E%22">Lok, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Milaneschi%2C+Y%2E%22">Milaneschi, Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Assies%2C+J%2E%22">Assies, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bockting%2C+C%2E+L%2E+H%2E%22">Bockting, C. L. H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Figueroa%2C+C%2E+A%2E%22">Figueroa, C. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giltay%2C+E%2E+J%2E%22">Giltay, E. J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Penninx%2C+B%2E+W%2E+J%2E+H%2E%22">Penninx, B. W. J. H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ruhé%2C+H%2E+G%2E%22">Ruhé, H. G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schene%2C+A%2E+H%2E%22">Schene, A. H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bot%2C+M%2E%22">Bot, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mocking%2C+R%2E+J%2E+T%2E%22">Mocking, R. J. T.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Apr2020, Vol. 141 Issue 4, p362-373. 12p. 1 Chart, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Fatty+acids%22">Fatty acids</searchLink><br /><searchLink fieldCode="DE" term="%22Unsaturated+fatty+acids%22">Unsaturated fatty acids</searchLink>
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  Data: Objective: Omega‐3 (n‐3) and omega‐6 (n‐6) polyunsaturated fatty acid (PUFA) alterations in patients with major depressive disorder (MDD) have been shown to persist after remission. Whether these alterations are risk factors for MDD recurrence remains unknown. Here, we examined whether fatty acids predict time until MDD recurrence in remitted MDD patients. Methods: Data were used from remitted MDD patients of the Netherlands Study of Depression and Anxiety (n = 356) and the Depression Evaluation Longitudinal Therapy Assessment studies (n = 118). Associations of FAs with time until MDD recurrence up to 8‐year follow‐up were analyzed using Cox regression analyses. Study‐specific estimates were pooled using mega‐ and meta‐analysis techniques. Results: 27.5% (NESDA) and 56.8% (DELTA) participants had an MDD recurrence. Pooled results showed that no FA was significantly associated with time until MDD recurrence (n‐3 PUFAs: hazard ratio (HR) = 1.17, 95% confidence interval (CI) = 0.98–1.41, P = 0.082; n‐6 PUFAs: HR = 1.08, 95% CI = 0.84–1.38, P = 0.55). Conclusion: In remitted MDD patients, circulating PUFAs were not associated with prospective risk of MDD recurrence. Consequently, circulating PUFAs are unlikely to reflect a vulnerability marker for recurrence, so correcting n‐3 PUFA 'deficits' through supplementation does not seem a promising option to prevent MDD recurrence. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Unsaturated fatty acids
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