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BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II.

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Title: BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II.
Authors: Markham, A. (AUTHOR), Cameron, I. (AUTHOR), Franklin, P. (AUTHOR), Spedding, M. (AUTHOR)
Source: European Journal of Neuroscience. Sep2004, Vol. 20 Issue 5, p1189-1196. 8p.
Subjects: Neurons, Nervous system, Brain, Mitochondria, Organelles, Protoplasm
Abstract: Brain-derived neurotrophic factor (BDNF) governs both the selective survival of neurons during development and the experience-based regulation of synaptic strength throughout life. BDNF produced a concentration-dependent increase in the respiratory control index (RCI, a measure of the efficiency of respiratory coupling, ATP synthesis and organelle integrity) of rat brain mitochondria. This effect was mediated via a MAP kinase pathway and highly specific for oxidation of glutamate plus malate (complex I) by brain mitochondria. The oxidation by brain mitochondria of the complex II substrate succinate was unaffected by BDNF. The failure of BDNF to modify respiratory activity associated with mitochondrial preparations isolated from rat liver indicates that the actions of the neurotrophin are tissue specific. BDNF also increased the RCI values associated with Ca2+-induced respiration to a similar extent. This is the first demonstration that BDNF, in addition to modifying neuronal plasticity, can modify brain metabolism and the efficiency of oxygen utilization. The finding that neurotrophins can alter mitochondrial oxidative efficiency has important implications for neurodegenerative and psychiatric diseases. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II.
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  Data: <searchLink fieldCode="AR" term="%22Markham%2C+A%2E%22">Markham, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cameron%2C+I%2E%22">Cameron, I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Franklin%2C+P%2E%22">Franklin, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spedding%2C+M%2E%22">Spedding, M.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2004, Vol. 20 Issue 5, p1189-1196. 8p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system%22">Nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondria%22">Mitochondria</searchLink><br /><searchLink fieldCode="DE" term="%22Organelles%22">Organelles</searchLink><br /><searchLink fieldCode="DE" term="%22Protoplasm%22">Protoplasm</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Brain-derived neurotrophic factor (BDNF) governs both the selective survival of neurons during development and the experience-based regulation of synaptic strength throughout life. BDNF produced a concentration-dependent increase in the respiratory control index (RCI, a measure of the efficiency of respiratory coupling, ATP synthesis and organelle integrity) of rat brain mitochondria. This effect was mediated via a MAP kinase pathway and highly specific for oxidation of glutamate plus malate (complex I) by brain mitochondria. The oxidation by brain mitochondria of the complex II substrate succinate was unaffected by BDNF. The failure of BDNF to modify respiratory activity associated with mitochondrial preparations isolated from rat liver indicates that the actions of the neurotrophin are tissue specific. BDNF also increased the RCI values associated with Ca2+-induced respiration to a similar extent. This is the first demonstration that BDNF, in addition to modifying neuronal plasticity, can modify brain metabolism and the efficiency of oxygen utilization. The finding that neurotrophins can alter mitochondrial oxidative efficiency has important implications for neurodegenerative and psychiatric diseases. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/j.1460-9568.2004.03578.x
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 8
        StartPage: 1189
    Subjects:
      – SubjectFull: Neurons
        Type: general
      – SubjectFull: Nervous system
        Type: general
      – SubjectFull: Brain
        Type: general
      – SubjectFull: Mitochondria
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      – SubjectFull: Organelles
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      – SubjectFull: Protoplasm
        Type: general
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      – TitleFull: BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II.
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            NameFull: Markham, A.
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            NameFull: Cameron, I.
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            NameFull: Franklin, P.
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            NameFull: Spedding, M.
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            – D: 01
              M: 09
              Text: Sep2004
              Type: published
              Y: 2004
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            – TitleFull: European Journal of Neuroscience
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