Chuanxiong (Rhizome of Ligusticum chuanxiong) Protects Ovariectomized Hyperlipidemic Rats from Bone Loss.
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| Title: | Chuanxiong (Rhizome of Ligusticum chuanxiong) Protects Ovariectomized Hyperlipidemic Rats from Bone Loss. |
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| Authors: | Dong, Xiao-Li (AUTHOR), Yu, Wen-Xuan (AUTHOR), Li, Chun-Mei (AUTHOR), Zhou, Li-Ping (AUTHOR), Wong, Man-Sau (AUTHOR) |
| Source: | American Journal of Chinese Medicine. 2020, Vol. 48 Issue 2, p463-485. 23p. 4 Charts, 6 Graphs. |
| Subjects: | Cardiovascular disease prevention, Lipid metabolism, Osteoporosis prevention, Medicinal plants, Animal experimentation, Herbal medicine, Hyperlipidemia, Chinese medicine, Ovariectomy, Rats, Plant extracts, Oxidative stress, Therapeutics |
| Geographic Terms: | China |
| Abstract: | Oxidative stress (OS) is the common mechanism for age-related diseases. The co-occurrence of osteoporosis (OP) and cardiovascular disease (CVD) in postmenopausal women makes it warranted to find a holistic approach for treatment of multiple diseases or conditions. The rhizome of Ligusticum chuanxiong Hort. (CX), which has high anti-oxidant properties and is widely used for CVD treatment in China, might be the potential candidate. In the present study, CX ethanol extract (CXE) was applied to H2O2 induced MG63 cells to study its effects and mechanisms on osteoblastogenesis against OS. CXE was then administered to six-month-old Sprague Dawley sham or ovariectomized (OVX) rats fed either a low saturated fat-sucrose (LFS) or a high fat-sucrose (HFS) diet for 12 weeks, to confirm its anti-osteoporotic effects. The results demonstrated that CXE directly improved proliferation and differentiation in vitro in an H2O2-induced osteoblast cell model by attenuating cellular reactive oxygen species levels and inhibiting osteoblast apoptosis via PI3K/Akt signaling pathway. CXE significantly improved bone properties as revealed by the increase in trabecular bone mineral density and decrease in trabecular separation at proximal metaphysis of the tibia (PT) in HFS-fed OVX rats but not in LFS-fed OVX rats. CXE ameliorated dyslipidemia, greatly reduced lipid deposition and malondialdehyde levels, improved activities of superoxide dismutase, catalase and glutathione peroxidase in the livers of HFS-fed OVX rats. In conclusion, CXE could favor osteoblastogenesis against OS. The ability of CXE to reduce bone loss in HFS-fed OVX rats was associated with its abilities to correct dyslipidemia, and reduce lipid deposition and OS levels. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 142947967 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Chuanxiong (Rhizome of Ligusticum chuanxiong) Protects Ovariectomized Hyperlipidemic Rats from Bone Loss. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dong%2C+Xiao-Li%22">Dong, Xiao-Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Wen-Xuan%22">Yu, Wen-Xuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Chun-Mei%22">Li, Chun-Mei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Li-Ping%22">Zhou, Li-Ping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wong%2C+Man-Sau%22">Wong, Man-Sau</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2020, Vol. 48 Issue 2, p463-485. 23p. 4 Charts, 6 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cardiovascular+disease+prevention%22">Cardiovascular disease prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Lipid+metabolism%22">Lipid metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Osteoporosis+prevention%22">Osteoporosis prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Medicinal+plants%22">Medicinal plants</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Herbal+medicine%22">Herbal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperlipidemia%22">Hyperlipidemia</searchLink><br /><searchLink fieldCode="DE" term="%22Chinese+medicine%22">Chinese medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Ovariectomy%22">Ovariectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+extracts%22">Plant extracts</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22China%22">China</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Oxidative stress (OS) is the common mechanism for age-related diseases. The co-occurrence of osteoporosis (OP) and cardiovascular disease (CVD) in postmenopausal women makes it warranted to find a holistic approach for treatment of multiple diseases or conditions. The rhizome of Ligusticum chuanxiong Hort. (CX), which has high anti-oxidant properties and is widely used for CVD treatment in China, might be the potential candidate. In the present study, CX ethanol extract (CXE) was applied to H2O2 induced MG63 cells to study its effects and mechanisms on osteoblastogenesis against OS. CXE was then administered to six-month-old Sprague Dawley sham or ovariectomized (OVX) rats fed either a low saturated fat-sucrose (LFS) or a high fat-sucrose (HFS) diet for 12 weeks, to confirm its anti-osteoporotic effects. The results demonstrated that CXE directly improved proliferation and differentiation in vitro in an H2O2-induced osteoblast cell model by attenuating cellular reactive oxygen species levels and inhibiting osteoblast apoptosis via PI3K/Akt signaling pathway. CXE significantly improved bone properties as revealed by the increase in trabecular bone mineral density and decrease in trabecular separation at proximal metaphysis of the tibia (PT) in HFS-fed OVX rats but not in LFS-fed OVX rats. CXE ameliorated dyslipidemia, greatly reduced lipid deposition and malondialdehyde levels, improved activities of superoxide dismutase, catalase and glutathione peroxidase in the livers of HFS-fed OVX rats. In conclusion, CXE could favor osteoblastogenesis against OS. The ability of CXE to reduce bone loss in HFS-fed OVX rats was associated with its abilities to correct dyslipidemia, and reduce lipid deposition and OS levels. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1142/S0192415X2050024X Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 23 StartPage: 463 Subjects: – SubjectFull: Cardiovascular disease prevention Type: general – SubjectFull: Lipid metabolism Type: general – SubjectFull: Osteoporosis prevention Type: general – SubjectFull: Medicinal plants Type: general – SubjectFull: Animal experimentation Type: general – SubjectFull: Herbal medicine Type: general – SubjectFull: Hyperlipidemia Type: general – SubjectFull: Chinese medicine Type: general – SubjectFull: Ovariectomy Type: general – SubjectFull: Rats Type: general – SubjectFull: Plant extracts Type: general – SubjectFull: Oxidative stress Type: general – SubjectFull: Therapeutics Type: general – SubjectFull: China Type: general Titles: – TitleFull: Chuanxiong (Rhizome of Ligusticum chuanxiong) Protects Ovariectomized Hyperlipidemic Rats from Bone Loss. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dong, Xiao-Li – PersonEntity: Name: NameFull: Yu, Wen-Xuan – PersonEntity: Name: NameFull: Li, Chun-Mei – PersonEntity: Name: NameFull: Zhou, Li-Ping – PersonEntity: Name: NameFull: Wong, Man-Sau IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 0192415X Numbering: – Type: volume Value: 48 – Type: issue Value: 2 Titles: – TitleFull: American Journal of Chinese Medicine Type: main |
| ResultId | 1 |
