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Observed psychopathology in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.

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Title: Observed psychopathology in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.
Authors: Sandstrom, A., MacKenzie, L., Pizzo, A., Fine, A., Rempel, S., Howard, C., Stephens, M., Patterson, V. C., Drobinin, V., Van Gestel, H., Howes Vallis, E., Zwicker, A., Propper, L., Abidi, S., Bagnell, A., Lovas, D., Cumby, J., Alda, M., Uher, R., Pavlova, B.
Source: Psychological Medicine. Apr2020, Vol. 50 Issue 6, p1050-1056. 7p.
Subjects: Attention-deficit hyperactivity disorder, Behavior disorders in children, Children of parents with disabilities, Mental depression, Language disorders, Bipolar disorder, Pathological psychology, Schizophrenia, Psychosocial factors, Anxiety disorders
Abstract: Background: Children of parents with mood and psychotic disorders are at elevated risk for a range of behavioral and emotional problems. However, as the usual reporter of psychopathology in children is the parent, reports of early problems in children of parents with mood and psychotic disorders may be biased by the parents' own experience of mental illness and their mental state. Methods: Independent observers rated psychopathology using the Test Observation Form in 378 children and youth between the ages of 4 and 24 (mean = 11.01, s.d. = 4.40) who had a parent with major depressive disorder, bipolar disorder, schizophrenia, or no history of mood and psychotic disorders. Results: Observed attentional problems were elevated in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia (effect sizes ranging between 0.31 and 0.56). Oppositional behavior and language/thought problems showed variable degrees of elevation (effect sizes 0.17 to 0.57) across the three high-risk groups, with the greatest difficulties observed in offspring of parents with bipolar disorder. Observed anxiety was increased in offspring of parents with major depressive disorder and bipolar disorder (effect sizes 0.19 and 0.25 respectively) but not in offspring of parents with schizophrenia. Conclusions: Our results suggest that externalizing problems and cognitive and language difficulties may represent a general manifestation of familial risk for mood and psychotic disorders, while anxiety may be a specific marker of liability for mood disorders. Observer assessment may improve early identification of risk and selection of youth who may benefit from targeted prevention. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Observed psychopathology in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Sandstrom%2C+A%2E%22">Sandstrom, A.</searchLink><br /><searchLink fieldCode="AR" term="%22MacKenzie%2C+L%2E%22">MacKenzie, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Pizzo%2C+A%2E%22">Pizzo, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Fine%2C+A%2E%22">Fine, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Rempel%2C+S%2E%22">Rempel, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Howard%2C+C%2E%22">Howard, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Stephens%2C+M%2E%22">Stephens, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Patterson%2C+V%2E+C%2E%22">Patterson, V. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Drobinin%2C+V%2E%22">Drobinin, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Gestel%2C+H%2E%22">Van Gestel, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Howes+Vallis%2C+E%2E%22">Howes Vallis, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Zwicker%2C+A%2E%22">Zwicker, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Propper%2C+L%2E%22">Propper, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Abidi%2C+S%2E%22">Abidi, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Bagnell%2C+A%2E%22">Bagnell, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Lovas%2C+D%2E%22">Lovas, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Cumby%2C+J%2E%22">Cumby, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Alda%2C+M%2E%22">Alda, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Uher%2C+R%2E%22">Uher, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Pavlova%2C+B%2E%22">Pavlova, B.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Apr2020, Vol. 50 Issue 6, p1050-1056. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+disorders+in+children%22">Behavior disorders in children</searchLink><br /><searchLink fieldCode="DE" term="%22Children+of+parents+with+disabilities%22">Children of parents with disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Language+disorders%22">Language disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Psychosocial+factors%22">Psychosocial factors</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Children of parents with mood and psychotic disorders are at elevated risk for a range of behavioral and emotional problems. However, as the usual reporter of psychopathology in children is the parent, reports of early problems in children of parents with mood and psychotic disorders may be biased by the parents' own experience of mental illness and their mental state. Methods: Independent observers rated psychopathology using the Test Observation Form in 378 children and youth between the ages of 4 and 24 (mean = 11.01, s.d. = 4.40) who had a parent with major depressive disorder, bipolar disorder, schizophrenia, or no history of mood and psychotic disorders. Results: Observed attentional problems were elevated in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia (effect sizes ranging between 0.31 and 0.56). Oppositional behavior and language/thought problems showed variable degrees of elevation (effect sizes 0.17 to 0.57) across the three high-risk groups, with the greatest difficulties observed in offspring of parents with bipolar disorder. Observed anxiety was increased in offspring of parents with major depressive disorder and bipolar disorder (effect sizes 0.19 and 0.25 respectively) but not in offspring of parents with schizophrenia. Conclusions: Our results suggest that externalizing problems and cognitive and language difficulties may represent a general manifestation of familial risk for mood and psychotic disorders, while anxiety may be a specific marker of liability for mood disorders. Observer assessment may improve early identification of risk and selection of youth who may benefit from targeted prevention. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=142977010
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        Value: 10.1017/S0033291719001089
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        Text: English
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      – SubjectFull: Behavior disorders in children
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