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Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats.

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Title: Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats.
Authors: Kimbrough, Adam (AUTHOR), Kononoff, Jenni (AUTHOR), Simpson, Sierra (AUTHOR), Kallupi, Marsida (AUTHOR), Sedighim, Sharona (AUTHOR), Palomino, Kenia (AUTHOR), Conlisk, Dana (AUTHOR), Momper, Jeremiah D. (AUTHOR), de Guglielmo, Giordano (AUTHOR), George, Olivier (AUTHOR)
Source: Psychopharmacology. May2020, Vol. 237 Issue 5, p1545-1555. 11p. 1 Diagram, 1 Chart, 3 Graphs.
Subjects: Rats, Oxycodone, Test validity, Predictive validity, Drug withdrawal symptoms, Nociceptive pain, Hyperalgesia
Abstract: Rationale: Over the last decade, oxycodone has become one of the most widely abused drugs in the USA. Oxycodone use disorder (OUD) is a serious health problem that has prompted a need to develop animal models of OUD that have both face and predictive validity. Oxycodone use in humans is more prevalent in women and leads to pronounced hyperalgesia and irritability during withdrawal. However, unclear is whether current animal models of oxycodone self-administration recapitulate these characteristics in humans. Objectives: We assessed the face validity of a model of extended-access oxycodone self-administration in rats by examining the escalation of oxycodone intake and behavioral symptoms of withdrawal, including irritability-like behavior and mechanical nociception, in male and female Wistar rats. Results: Both male and female rats escalated their oxycodone intake over fourteen 12-h self-administration sessions. After escalation, female rats administered more drug than male rats. No differences in plasma oxycodone levels were identified, but males had a significantly higher level of oxycodone in the brain at 30 min. Extended access to oxycodone significantly decreased aggressive-like behavior and increased defensive-like behaviors when tested immediately after a 12-h self-administration session, followed by a rebound increase in aggressive-like behavior 12 h into withdrawal. Tests of mechanical nociception thresholds during withdrawal indicated pronounced hyperalgesia. No sex differences in irritability-like behavior or pain sensitivity were observed. Conclusions: The present study demonstrated the face validity of the extended access model of oxycodone self-administration by identifying sex differences in the escalation of oxycodone intake and pronounced changes in pain and affective states. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats.
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  Data: <searchLink fieldCode="AR" term="%22Kimbrough%2C+Adam%22">Kimbrough, Adam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kononoff%2C+Jenni%22">Kononoff, Jenni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Simpson%2C+Sierra%22">Simpson, Sierra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kallupi%2C+Marsida%22">Kallupi, Marsida</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sedighim%2C+Sharona%22">Sedighim, Sharona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palomino%2C+Kenia%22">Palomino, Kenia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Conlisk%2C+Dana%22">Conlisk, Dana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Momper%2C+Jeremiah+D%2E%22">Momper, Jeremiah D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Guglielmo%2C+Giordano%22">de Guglielmo, Giordano</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22George%2C+Olivier%22">George, Olivier</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. May2020, Vol. 237 Issue 5, p1545-1555. 11p. 1 Diagram, 1 Chart, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Oxycodone%22">Oxycodone</searchLink><br /><searchLink fieldCode="DE" term="%22Test+validity%22">Test validity</searchLink><br /><searchLink fieldCode="DE" term="%22Predictive+validity%22">Predictive validity</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+withdrawal+symptoms%22">Drug withdrawal symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Nociceptive+pain%22">Nociceptive pain</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperalgesia%22">Hyperalgesia</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Rationale: Over the last decade, oxycodone has become one of the most widely abused drugs in the USA. Oxycodone use disorder (OUD) is a serious health problem that has prompted a need to develop animal models of OUD that have both face and predictive validity. Oxycodone use in humans is more prevalent in women and leads to pronounced hyperalgesia and irritability during withdrawal. However, unclear is whether current animal models of oxycodone self-administration recapitulate these characteristics in humans. Objectives: We assessed the face validity of a model of extended-access oxycodone self-administration in rats by examining the escalation of oxycodone intake and behavioral symptoms of withdrawal, including irritability-like behavior and mechanical nociception, in male and female Wistar rats. Results: Both male and female rats escalated their oxycodone intake over fourteen 12-h self-administration sessions. After escalation, female rats administered more drug than male rats. No differences in plasma oxycodone levels were identified, but males had a significantly higher level of oxycodone in the brain at 30 min. Extended access to oxycodone significantly decreased aggressive-like behavior and increased defensive-like behaviors when tested immediately after a 12-h self-administration session, followed by a rebound increase in aggressive-like behavior 12 h into withdrawal. Tests of mechanical nociception thresholds during withdrawal indicated pronounced hyperalgesia. No sex differences in irritability-like behavior or pain sensitivity were observed. Conclusions: The present study demonstrated the face validity of the extended access model of oxycodone self-administration by identifying sex differences in the escalation of oxycodone intake and pronounced changes in pain and affective states. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Oxycodone
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              Text: May2020
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