Contingent negative variation: a biomarker of abnormal attention in functional movement disorders.
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| Title: | Contingent negative variation: a biomarker of abnormal attention in functional movement disorders. |
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| Authors: | Teodoro, T. (AUTHOR), Koreki, A. (AUTHOR), Meppelink, A. M. (AUTHOR), Little, S. (AUTHOR), Nielsen, G. (AUTHOR), Macerollo, A. (AUTHOR), Ferreira, J. J. (AUTHOR), Pareés, I. (AUTHOR), Lang, A. (AUTHOR), Edwards, M. J. (AUTHOR) |
| Source: | European Journal of Neurology. Jun2020, Vol. 27 Issue 6, p985-994. 10p. 1 Chart, 4 Graphs. |
| Subjects: | Movement disorders, Physical therapy, Attention, Neurological disorders, Logarithms |
| Abstract: | Background and purpose: Contingent negative variation (CNV) is a negative cortical wave that precedes a pre‐cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention. The aim was to ascertain whether the clinical improvement of functional movement disorders after physiotherapy would be associated with faster reaction times and modulation of CNV. Methods: Motor performance and CNV were analysed during a pre‐cued choice reaction time task with varying cue validity. Twenty‐one patients with functional movement disorders and 13 healthy controls at baseline were compared. Patients then underwent physiotherapy. At follow‐up after physiotherapy, patients were categorized as clinically improved (responders) or not improved (non‐responders) and retested. Results: At baseline, patients did not generate CNV, contrary to controls [mean amplitude (µV) at the end of preparation to move: patients −0.47 (95% CI −1.94, 1.00) versus controls −2.59 (95% CI −4.46, −0.72)]. Responders performed faster after physiotherapy [mean natural logarithm (ln) reaction time (RT) (ms): follow‐up 6.112 (95% CI 5.923, 6.301) versus baseline 6.206 (95% CI 6.019, 6.394), P = 0.010], contrary to non‐responders. Simultaneously, responders showed a recovery of CNV after physiotherapy [follow‐up −1.95 (95% CI −3.49, −0.41) versus baseline −0.19 (95% CI −1.73, 1.35), P < 0.001], contrary to non‐responders [follow‐up −0.32 (95% CI −1.79, 1.14) versus baseline −0.72 (95% CI −2.19, 0.75), P = 0.381]. Conclusions: Clinical improvement of functional movement disorders after physiotherapy was associated with faster reaction times and normalization of CNV, which was absent at baseline. These findings suggest that CNV may constitute a useful neurophysiological biomarker related to abnormal attention in functional movement disorders. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 143217465 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Contingent negative variation: a biomarker of abnormal attention in functional movement disorders. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Teodoro%2C+T%2E%22">Teodoro, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koreki%2C+A%2E%22">Koreki, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meppelink%2C+A%2E+M%2E%22">Meppelink, A. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Little%2C+S%2E%22">Little, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nielsen%2C+G%2E%22">Nielsen, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Macerollo%2C+A%2E%22">Macerollo, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferreira%2C+J%2E+J%2E%22">Ferreira, J. J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pareés%2C+I%2E%22">Pareés, I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lang%2C+A%2E%22">Lang, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Edwards%2C+M%2E+J%2E%22">Edwards, M. J.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jun2020, Vol. 27 Issue 6, p985-994. 10p. 1 Chart, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Movement+disorders%22">Movement disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+therapy%22">Physical therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Attention%22">Attention</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Logarithms%22">Logarithms</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose: Contingent negative variation (CNV) is a negative cortical wave that precedes a pre‐cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention. The aim was to ascertain whether the clinical improvement of functional movement disorders after physiotherapy would be associated with faster reaction times and modulation of CNV. Methods: Motor performance and CNV were analysed during a pre‐cued choice reaction time task with varying cue validity. Twenty‐one patients with functional movement disorders and 13 healthy controls at baseline were compared. Patients then underwent physiotherapy. At follow‐up after physiotherapy, patients were categorized as clinically improved (responders) or not improved (non‐responders) and retested. Results: At baseline, patients did not generate CNV, contrary to controls [mean amplitude (µV) at the end of preparation to move: patients −0.47 (95% CI −1.94, 1.00) versus controls −2.59 (95% CI −4.46, −0.72)]. Responders performed faster after physiotherapy [mean natural logarithm (ln) reaction time (RT) (ms): follow‐up 6.112 (95% CI 5.923, 6.301) versus baseline 6.206 (95% CI 6.019, 6.394), P = 0.010], contrary to non‐responders. Simultaneously, responders showed a recovery of CNV after physiotherapy [follow‐up −1.95 (95% CI −3.49, −0.41) versus baseline −0.19 (95% CI −1.73, 1.35), P < 0.001], contrary to non‐responders [follow‐up −0.32 (95% CI −1.79, 1.14) versus baseline −0.72 (95% CI −2.19, 0.75), P = 0.381]. Conclusions: Clinical improvement of functional movement disorders after physiotherapy was associated with faster reaction times and normalization of CNV, which was absent at baseline. These findings suggest that CNV may constitute a useful neurophysiological biomarker related to abnormal attention in functional movement disorders. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.14189 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 985 Subjects: – SubjectFull: Movement disorders Type: general – SubjectFull: Physical therapy Type: general – SubjectFull: Attention Type: general – SubjectFull: Neurological disorders Type: general – SubjectFull: Logarithms Type: general Titles: – TitleFull: Contingent negative variation: a biomarker of abnormal attention in functional movement disorders. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Teodoro, T. – PersonEntity: Name: NameFull: Koreki, A. – PersonEntity: Name: NameFull: Meppelink, A. M. – PersonEntity: Name: NameFull: Little, S. – PersonEntity: Name: NameFull: Nielsen, G. – PersonEntity: Name: NameFull: Macerollo, A. – PersonEntity: Name: NameFull: Ferreira, J. J. – PersonEntity: Name: NameFull: Pareés, I. – PersonEntity: Name: NameFull: Lang, A. – PersonEntity: Name: NameFull: Edwards, M. J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 27 – Type: issue Value: 6 Titles: – TitleFull: European Journal of Neurology Type: main |
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