View in EDS HTML Full Text PDF Full Text

Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis.

Saved in:
Bibliographic Details
Title: Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis.
Authors: Kim, Su Il, Kwon, Oh Eun, Park, Jung Min, Doo, Jeon Gang, Kim, Seok Hyun, Jung, Hae Rim, Min, Jin Young, Kim, Sung Wan, Lee, Young Chan, Eun, Young-Gyu
Source: Annals of Otology, Rhinology & Laryngology. Jun2020, Vol. 129 Issue 6, p542-547. 6p.
Subjects: Biomarkers, Enzyme-linked immunosorbent assay, Fluids, Glycoproteins, Interleukins, Research funding, Rhinitis, Severity of illness index, Nasal irrigation, Symptoms
Abstract: Objectives: This study investigated whether the biomarkers present in nasal fluid reflect the severity of symptoms in patients with persistent allergic rhinitis (PAR). Methods: We enrolled 29 PAR patients complaining of nasal symptoms and testing positive to skin prick test. Patients' total nasal symptom score (TNSS) was measured and their nasal lavage fluid (NALF) was collected. The levels of biomarkers including Clara cell protein 16 (CC16), tryptase, and interleukin 5 (IL-5) in NALF were determined via enzyme-linked immunosorbent assay (ELISA). Results: PAR patients were classified into persistent mild and persistent moderate-to-severe groups according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The CC16 alone was significantly negatively correlated with TNSS (P <.05). Further, the CC16 level was significantly lower in persistent moderate-to-severe group than persistent mild group of patients (P <.05). Conclusions: The levels of CC16 alone among several NALF biomarkers showed an inverse correlation with symptoms of PAR patients. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 143230355
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kim%2C+Su+Il%22&quot;&gt;Kim, Su Il&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kwon%2C+Oh+Eun%22&quot;&gt;Kwon, Oh Eun&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Park%2C+Jung+Min%22&quot;&gt;Park, Jung Min&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Doo%2C+Jeon+Gang%22&quot;&gt;Doo, Jeon Gang&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kim%2C+Seok+Hyun%22&quot;&gt;Kim, Seok Hyun&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jung%2C+Hae+Rim%22&quot;&gt;Jung, Hae Rim&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Min%2C+Jin+Young%22&quot;&gt;Min, Jin Young&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kim%2C+Sung+Wan%22&quot;&gt;Kim, Sung Wan&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lee%2C+Young+Chan%22&quot;&gt;Lee, Young Chan&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Eun%2C+Young-Gyu%22&quot;&gt;Eun, Young-Gyu&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22&quot;&gt;Annals of Otology, Rhinology &amp; Laryngology&lt;/searchLink&gt;. Jun2020, Vol. 129 Issue 6, p542-547. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biomarkers%22&quot;&gt;Biomarkers&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Enzyme-linked+immunosorbent+assay%22&quot;&gt;Enzyme-linked immunosorbent assay&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fluids%22&quot;&gt;Fluids&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Glycoproteins%22&quot;&gt;Glycoproteins&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Interleukins%22&quot;&gt;Interleukins&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research+funding%22&quot;&gt;Research funding&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Rhinitis%22&quot;&gt;Rhinitis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Severity+of+illness+index%22&quot;&gt;Severity of illness index&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nasal+irrigation%22&quot;&gt;Nasal irrigation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Symptoms%22&quot;&gt;Symptoms&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: This study investigated whether the biomarkers present in nasal fluid reflect the severity of symptoms in patients with persistent allergic rhinitis (PAR). Methods: We enrolled 29 PAR patients complaining of nasal symptoms and testing positive to skin prick test. Patients&#39; total nasal symptom score (TNSS) was measured and their nasal lavage fluid (NALF) was collected. The levels of biomarkers including Clara cell protein 16 (CC16), tryptase, and interleukin 5 (IL-5) in NALF were determined via enzyme-linked immunosorbent assay (ELISA). Results: PAR patients were classified into persistent mild and persistent moderate-to-severe groups according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The CC16 alone was significantly negatively correlated with TNSS (P &lt;.05). Further, the CC16 level was significantly lower in persistent moderate-to-severe group than persistent mild group of patients (P &lt;.05). Conclusions: The levels of CC16 alone among several NALF biomarkers showed an inverse correlation with symptoms of PAR patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Annals of Otology, Rhinology &amp; Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=143230355
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1177/0003489419898717
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 542
    Subjects:
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Enzyme-linked immunosorbent assay
        Type: general
      – SubjectFull: Fluids
        Type: general
      – SubjectFull: Glycoproteins
        Type: general
      – SubjectFull: Interleukins
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Rhinitis
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
      – SubjectFull: Nasal irrigation
        Type: general
      – SubjectFull: Symptoms
        Type: general
    Titles:
      – TitleFull: Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kim, Su Il
      – PersonEntity:
          Name:
            NameFull: Kwon, Oh Eun
      – PersonEntity:
          Name:
            NameFull: Park, Jung Min
      – PersonEntity:
          Name:
            NameFull: Doo, Jeon Gang
      – PersonEntity:
          Name:
            NameFull: Kim, Seok Hyun
      – PersonEntity:
          Name:
            NameFull: Jung, Hae Rim
      – PersonEntity:
          Name:
            NameFull: Min, Jin Young
      – PersonEntity:
          Name:
            NameFull: Kim, Sung Wan
      – PersonEntity:
          Name:
            NameFull: Lee, Young Chan
      – PersonEntity:
          Name:
            NameFull: Eun, Young-Gyu
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 00034894
          Numbering:
            – Type: volume
              Value: 129
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Annals of Otology, Rhinology & Laryngology
              Type: main
ResultId 1