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Peripheral Nerve Field Stimulation for Chronic Back Pain: Therapy Outcome Predictive Factors.

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Title: Peripheral Nerve Field Stimulation for Chronic Back Pain: Therapy Outcome Predictive Factors.
Authors: Gorp, Eric‐Jan, Eldabe, Sam, Slavin, Konstantin V., Rigoard, Philippe, Goossens, Stefaan, Mielke, Dorothee, Barolat, Giancarlo, Declerck, Christ, Gilmore, Chris, Gültuna, Ismaïl, Vissers, Kris C.P., Tinsley, Jennifer, Likar, Rudolf, Luyet, Pierre‐Philippe
Source: Pain Practice. Jun2020, Vol. 20 Issue 5, p522-533. 12p. 5 Charts.
Subjects: Treatment of backaches, Chronic pain treatment, Age distribution, Mental depression, Leg, Multivariate analysis, Neurosurgery, Neural stimulation, Neuralgia, Quality of life, Research, Spinal cord, Statistics, Sample size (Statistics), Treatment effectiveness, Severity of illness index, Functional assessment
Abstract: Objective: To identify variables that influence pain reduction following peripheral nerve field stimulation (PNFS) in order to identify a potential responder profile. Methods: Exploratory univariate and multivariate (random forest) analyses were performed separately on 2 randomized controlled trials and a registry; all included patients with chronic back pain, mainly failed back surgery syndrome. An international expert panel judged the clinical relevance of variables to identify responders by consensus. Results: Variables identified that may help predict PNFS success in patients with back pain include patient and pain characteristics (age, time since onset of pain and spinal surgery, pain medication history, position and size of pain area, pain severity, mixed nociceptive/neuropathic pain, health‐related quality of life, depression, functional disability, and leg pain status), implant procedure variables (the number and position of leads, paresthesia coverage, and amount of pain relief during the trial), and programming (number of programs, cathodes, and anodes; pulse rate; pulse width; and percentage of device usage). Conclusions: While these analyses are exploratory and restricted to a limited sample size, they suggest variables that may play a role in predicting a therapeutic response. These results, however, are informative only and should be cautiously interpreted. Future research to validate the variables in a clinical study is needed. [ABSTRACT FROM AUTHOR]
Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Peripheral Nerve Field Stimulation for Chronic Back Pain: Therapy Outcome Predictive Factors.
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  Data: <searchLink fieldCode="AR" term="%22Gorp%2C+Eric‐Jan%22">Gorp, Eric‐Jan</searchLink><br /><searchLink fieldCode="AR" term="%22Eldabe%2C+Sam%22">Eldabe, Sam</searchLink><br /><searchLink fieldCode="AR" term="%22Slavin%2C+Konstantin+V%2E%22">Slavin, Konstantin V.</searchLink><br /><searchLink fieldCode="AR" term="%22Rigoard%2C+Philippe%22">Rigoard, Philippe</searchLink><br /><searchLink fieldCode="AR" term="%22Goossens%2C+Stefaan%22">Goossens, Stefaan</searchLink><br /><searchLink fieldCode="AR" term="%22Mielke%2C+Dorothee%22">Mielke, Dorothee</searchLink><br /><searchLink fieldCode="AR" term="%22Barolat%2C+Giancarlo%22">Barolat, Giancarlo</searchLink><br /><searchLink fieldCode="AR" term="%22Declerck%2C+Christ%22">Declerck, Christ</searchLink><br /><searchLink fieldCode="AR" term="%22Gilmore%2C+Chris%22">Gilmore, Chris</searchLink><br /><searchLink fieldCode="AR" term="%22Gültuna%2C+Ismaïl%22">Gültuna, Ismaïl</searchLink><br /><searchLink fieldCode="AR" term="%22Vissers%2C+Kris+C%2EP%2E%22">Vissers, Kris C.P.</searchLink><br /><searchLink fieldCode="AR" term="%22Tinsley%2C+Jennifer%22">Tinsley, Jennifer</searchLink><br /><searchLink fieldCode="AR" term="%22Likar%2C+Rudolf%22">Likar, Rudolf</searchLink><br /><searchLink fieldCode="AR" term="%22Luyet%2C+Pierre‐Philippe%22">Luyet, Pierre‐Philippe</searchLink>
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  Label: Abstract
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  Data: Objective: To identify variables that influence pain reduction following peripheral nerve field stimulation (PNFS) in order to identify a potential responder profile. Methods: Exploratory univariate and multivariate (random forest) analyses were performed separately on 2 randomized controlled trials and a registry; all included patients with chronic back pain, mainly failed back surgery syndrome. An international expert panel judged the clinical relevance of variables to identify responders by consensus. Results: Variables identified that may help predict PNFS success in patients with back pain include patient and pain characteristics (age, time since onset of pain and spinal surgery, pain medication history, position and size of pain area, pain severity, mixed nociceptive/neuropathic pain, health‐related quality of life, depression, functional disability, and leg pain status), implant procedure variables (the number and position of leads, paresthesia coverage, and amount of pain relief during the trial), and programming (number of programs, cathodes, and anodes; pulse rate; pulse width; and percentage of device usage). Conclusions: While these analyses are exploratory and restricted to a limited sample size, they suggest variables that may play a role in predicting a therapeutic response. These results, however, are informative only and should be cautiously interpreted. Future research to validate the variables in a clinical study is needed. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=143594759
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        Value: 10.1111/papr.12880
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        Text: English
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        StartPage: 522
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      – SubjectFull: Treatment of backaches
        Type: general
      – SubjectFull: Chronic pain treatment
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      – SubjectFull: Age distribution
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      – SubjectFull: Mental depression
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      – SubjectFull: Leg
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      – SubjectFull: Multivariate analysis
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      – SubjectFull: Neurosurgery
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      – SubjectFull: Neural stimulation
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      – SubjectFull: Neuralgia
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      – SubjectFull: Spinal cord
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Severity of illness index
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      – SubjectFull: Functional assessment
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