Serial changes in fibrinolysis and coagulation activation markers in acute and convalescent phase of ischemic stroke.
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| Title: | Serial changes in fibrinolysis and coagulation activation markers in acute and convalescent phase of ischemic stroke. |
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| Authors: | Haapaniemi, E., Soinne, L., Syrjälä, M., Kaste, M., Tatlisumak, T. |
| Source: | Acta Neurologica Scandinavica. Oct2004, Vol. 110 Issue 4, p242-247. 6p. |
| Subjects: | Fibrinolysis, Blood coagulation, Biomarkers, Cerebrovascular disease, Cerebral infarction |
| Abstract: | Haapaniemi E, Soinne L, Syrjälä M, Kaste M, Tatlisumak T. Serial changes in fibrinolysis and coagulation activation markers in acute and convalescent phase of ischemic stroke.Acta Neurol Scand 2004 DOI: 10.1111/j.1600-0404.2004.00304.x© Blackwell Munksgaard 2004The changes in the activity of a number of plasma markers of coagulation and fibrinolysis have previously been studied in patients with ischemic stroke, with conflicting results. We aimed to find out the changes in the activities of a wide array of markers of the coagulation and the fibrinolytic system of mildly or moderately affected first-ever ischemic stroke patients.In a prospective, longitudinal, case–control study, we studied plasma plasminogen activator inhibitor type-1 (PAI-1) activity, tissue-type plasminogen activator antigen (t-PA:Ag), d-dimer, prothrombin fragment 1+2 (F 1+2), and thrombin–antithrombin III complex (TAT) levels in 55 consecutive patients on admission, 1 week, 1 month, and 3 months after an ischemic stroke. Sex- and age-matched controls were studied once. All patients underwent blood sampling at each study time point; comprehensive stroke risk factors were recorded, and the etiology of the ischemic stroke was determined. All patients were contacted 3 years later for possible recurrent ischemic events.PAI-1 activity was increased in the acute phase and at 3 months, D-dimer levels were significantly higher at 1 week and 1 month after stroke, whereas t-PA:Ag, TAT and F 1+2 levels remained stable during the whole study period.The changes of the fibrinolytic and coagulation system activity in the patients with mild or moderate ischemic stroke appeared minor compared with the results of previous studies, which included more severely ill patients. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 14359609 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Serial changes in fibrinolysis and coagulation activation markers in acute and convalescent phase of ischemic stroke. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Haapaniemi%2C+E%2E%22">Haapaniemi, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Soinne%2C+L%2E%22">Soinne, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Syrjälä%2C+M%2E%22">Syrjälä, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaste%2C+M%2E%22">Kaste, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Tatlisumak%2C+T%2E%22">Tatlisumak, T.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Oct2004, Vol. 110 Issue 4, p242-247. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Fibrinolysis%22">Fibrinolysis</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+coagulation%22">Blood coagulation</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebrovascular+disease%22">Cerebrovascular disease</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+infarction%22">Cerebral infarction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Haapaniemi E, Soinne L, Syrjälä M, Kaste M, Tatlisumak T. Serial changes in fibrinolysis and coagulation activation markers in acute and convalescent phase of ischemic stroke.Acta Neurol Scand 2004 DOI: 10.1111/j.1600-0404.2004.00304.x© Blackwell Munksgaard 2004The changes in the activity of a number of plasma markers of coagulation and fibrinolysis have previously been studied in patients with ischemic stroke, with conflicting results. We aimed to find out the changes in the activities of a wide array of markers of the coagulation and the fibrinolytic system of mildly or moderately affected first-ever ischemic stroke patients.In a prospective, longitudinal, case–control study, we studied plasma plasminogen activator inhibitor type-1 (PAI-1) activity, tissue-type plasminogen activator antigen (t-PA:Ag), d-dimer, prothrombin fragment 1+2 (F 1+2), and thrombin–antithrombin III complex (TAT) levels in 55 consecutive patients on admission, 1 week, 1 month, and 3 months after an ischemic stroke. Sex- and age-matched controls were studied once. All patients underwent blood sampling at each study time point; comprehensive stroke risk factors were recorded, and the etiology of the ischemic stroke was determined. All patients were contacted 3 years later for possible recurrent ischemic events.PAI-1 activity was increased in the acute phase and at 3 months, D-dimer levels were significantly higher at 1 week and 1 month after stroke, whereas t-PA:Ag, TAT and F 1+2 levels remained stable during the whole study period.The changes of the fibrinolytic and coagulation system activity in the patients with mild or moderate ischemic stroke appeared minor compared with the results of previous studies, which included more severely ill patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1600-0404.2004.00304.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 242 Subjects: – SubjectFull: Fibrinolysis Type: general – SubjectFull: Blood coagulation Type: general – SubjectFull: Biomarkers Type: general – SubjectFull: Cerebrovascular disease Type: general – SubjectFull: Cerebral infarction Type: general Titles: – TitleFull: Serial changes in fibrinolysis and coagulation activation markers in acute and convalescent phase of ischemic stroke. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Haapaniemi, E. – PersonEntity: Name: NameFull: Soinne, L. – PersonEntity: Name: NameFull: Syrjälä, M. – PersonEntity: Name: NameFull: Kaste, M. – PersonEntity: Name: NameFull: Tatlisumak, T. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 110 – Type: issue Value: 4 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
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