Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms.
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| Title: | Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms. |
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| Authors: | Schweppe, Catherine A. (AUTHOR), Burzynski, Caitlin (AUTHOR), Jayanthi, Subramaniam (AUTHOR), Ladenheim, Bruce (AUTHOR), Cadet, Jean Lud (AUTHOR), Gardner, Eliot L. (AUTHOR), Xi, Zheng-Xiong (AUTHOR), van Praag, Henriette (AUTHOR), Newman, Amy Hauck (AUTHOR), Keck, Thomas M. (AUTHOR) |
| Source: | Psychopharmacology. Jul2020, Vol. 237 Issue 7, p1989-2005. 17p. 1 Color Photograph, 9 Graphs. |
| Subjects: | Methamphetamine, Cognition disorders, Methamphetamine abuse, Pharmacology, Spatial memory, Brain damage |
| Abstract: | Rationale: Abuse of the psychostimulant methamphetamine (METH) can cause long-lasting damage to brain monoaminergic systems and is associated with profound mental health problems for users, including lasting cognitive impairments. Animal models of METH exposure have been useful in dissecting the molecular effects of the drug on cognition, but many studies use acute, non-contingent "binge" administrations of METH which do not adequately approximate human METH use. Long-term METH exposure via long-access (LgA) self-administration paradigms has been proposed to more closely reflect human use and induce cognitive impairments. Objective: To better understand the role of contingency and patterns of exposure in METH-induced cognitive impairments, we analyzed behavioral and neurochemical outcomes in adult male rats, comparing non-contingent "binge" METH administration with contingent (LgA) METH self-administration and non-contingent yoked partners. Results: Binge METH (40 mg/kg, i.p., over 1 day) dramatically altered striatal and hippocampal dopamine, DOPAC, 5-HT, 5-HIAA, BDNF, and TrkB 75 days after drug exposure. In contrast, 6-h LgA METH self-administration (cumulative 24.8–48.9 mg METH, i.v., over 16 days) altered hippocampal BDNF in both contingent and yoked animals but reduced striatal 5-HIAA in only contingent animals. Neurochemical alterations following binge METH administration were not accompanied by cognitive deficits in Morris water maze, novel object recognition, or Y-maze tests. However, contingent LgA METH self-administration resulted in impaired spatial memory in the water maze. Conclusions: Overall, substantial differences in neurochemical markers between METH exposure and self-administration paradigms did not consistently translate to deficits in cognitive tasks, highlighting the complexity of correlating METH-induced neurochemical changes with cognitive outcomes. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 143875259 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Schweppe%2C+Catherine+A%2E%22">Schweppe, Catherine A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burzynski%2C+Caitlin%22">Burzynski, Caitlin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jayanthi%2C+Subramaniam%22">Jayanthi, Subramaniam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ladenheim%2C+Bruce%22">Ladenheim, Bruce</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cadet%2C+Jean+Lud%22">Cadet, Jean Lud</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gardner%2C+Eliot+L%2E%22">Gardner, Eliot L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xi%2C+Zheng-Xiong%22">Xi, Zheng-Xiong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Praag%2C+Henriette%22">van Praag, Henriette</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Newman%2C+Amy+Hauck%22">Newman, Amy Hauck</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Keck%2C+Thomas+M%2E%22">Keck, Thomas M.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jul2020, Vol. 237 Issue 7, p1989-2005. 17p. 1 Color Photograph, 9 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Methamphetamine%22">Methamphetamine</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Methamphetamine+abuse%22">Methamphetamine abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacology%22">Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Spatial+memory%22">Spatial memory</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+damage%22">Brain damage</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Abuse of the psychostimulant methamphetamine (METH) can cause long-lasting damage to brain monoaminergic systems and is associated with profound mental health problems for users, including lasting cognitive impairments. Animal models of METH exposure have been useful in dissecting the molecular effects of the drug on cognition, but many studies use acute, non-contingent "binge" administrations of METH which do not adequately approximate human METH use. Long-term METH exposure via long-access (LgA) self-administration paradigms has been proposed to more closely reflect human use and induce cognitive impairments. Objective: To better understand the role of contingency and patterns of exposure in METH-induced cognitive impairments, we analyzed behavioral and neurochemical outcomes in adult male rats, comparing non-contingent "binge" METH administration with contingent (LgA) METH self-administration and non-contingent yoked partners. Results: Binge METH (40 mg/kg, i.p., over 1 day) dramatically altered striatal and hippocampal dopamine, DOPAC, 5-HT, 5-HIAA, BDNF, and TrkB 75 days after drug exposure. In contrast, 6-h LgA METH self-administration (cumulative 24.8–48.9 mg METH, i.v., over 16 days) altered hippocampal BDNF in both contingent and yoked animals but reduced striatal 5-HIAA in only contingent animals. Neurochemical alterations following binge METH administration were not accompanied by cognitive deficits in Morris water maze, novel object recognition, or Y-maze tests. However, contingent LgA METH self-administration resulted in impaired spatial memory in the water maze. Conclusions: Overall, substantial differences in neurochemical markers between METH exposure and self-administration paradigms did not consistently translate to deficits in cognitive tasks, highlighting the complexity of correlating METH-induced neurochemical changes with cognitive outcomes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=143875259 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-020-05513-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1989 Subjects: – SubjectFull: Methamphetamine Type: general – SubjectFull: Cognition disorders Type: general – SubjectFull: Methamphetamine abuse Type: general – SubjectFull: Pharmacology Type: general – SubjectFull: Spatial memory Type: general – SubjectFull: Brain damage Type: general Titles: – TitleFull: Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Schweppe, Catherine A. – PersonEntity: Name: NameFull: Burzynski, Caitlin – PersonEntity: Name: NameFull: Jayanthi, Subramaniam – PersonEntity: Name: NameFull: Ladenheim, Bruce – PersonEntity: Name: NameFull: Cadet, Jean Lud – PersonEntity: Name: NameFull: Gardner, Eliot L. – PersonEntity: Name: NameFull: Xi, Zheng-Xiong – PersonEntity: Name: NameFull: van Praag, Henriette – PersonEntity: Name: NameFull: Newman, Amy Hauck – PersonEntity: Name: NameFull: Keck, Thomas M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 237 – Type: issue Value: 7 Titles: – TitleFull: Psychopharmacology Type: main |
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