Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves.
Saved in:
| Title: | Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves. |
|---|---|
| Authors: | Court, Felipe A., Sherman, Diane L., Pratt, Thomas, Garry, Emer M., Ribchester, Richard R., Cottreall, David F., Fleetwood-Walker, Susan M., Brophy, Peter J. |
| Source: | Nature. 9/9/2004, Vol. 431 Issue 7005, p191-195. 5p. |
| Subjects: | Nerves, Impulse (Psychology), Nodes of Ranvier, Vertebrates, Cells, Cytoplasm |
| Abstract: | Nerve impulses are propagated at nodes of Ranvier in the myclinated nerves of vertebrates. Internodal distances have been proposed to affect the velocity of nerve impulse conduction1; however, direct evidence is lacking, and the cellular mechanisms that might regulate the length of the myclinated segments are unknown. Ramón y Cajal described longitudinal and transverse bands of cytoplasm or trabeculae in intemodal Schwann cells and suggested that they had a nutritive function2. Here we show that internodal growth in wild-type nerves is precisely matched to nerve extension, but disruption of the cytoplasmic bands in Periaxin-null mice impairs Schwann cell elongation during nerve growth. By contrast, myelination proceeds normally. The capacity of wild-type and mutant Schwann cells to elongate is cell-autonomous, indicating that passive stretching can account for the lengthening of the internode during limb growth. As predicted on theoretical grounds, decreased internodal distances strikingly decrease conduction velocities and so affect motor function. We propose that microtubule-based transport in the longitudinal bands of Cajal permits internodal Schwann cells to lengthen in response to axonal growth, thus ensuring rapid nerve impulse transmission. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 14396914 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Court%2C+Felipe+A%2E%22">Court, Felipe A.</searchLink><br /><searchLink fieldCode="AR" term="%22Sherman%2C+Diane+L%2E%22">Sherman, Diane L.</searchLink><br /><searchLink fieldCode="AR" term="%22Pratt%2C+Thomas%22">Pratt, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Garry%2C+Emer+M%2E%22">Garry, Emer M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ribchester%2C+Richard+R%2E%22">Ribchester, Richard R.</searchLink><br /><searchLink fieldCode="AR" term="%22Cottreall%2C+David+F%2E%22">Cottreall, David F.</searchLink><br /><searchLink fieldCode="AR" term="%22Fleetwood-Walker%2C+Susan+M%2E%22">Fleetwood-Walker, Susan M.</searchLink><br /><searchLink fieldCode="AR" term="%22Brophy%2C+Peter+J%2E%22">Brophy, Peter J.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 9/9/2004, Vol. 431 Issue 7005, p191-195. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nerves%22">Nerves</searchLink><br /><searchLink fieldCode="DE" term="%22Impulse+%28Psychology%29%22">Impulse (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Nodes+of+Ranvier%22">Nodes of Ranvier</searchLink><br /><searchLink fieldCode="DE" term="%22Vertebrates%22">Vertebrates</searchLink><br /><searchLink fieldCode="DE" term="%22Cells%22">Cells</searchLink><br /><searchLink fieldCode="DE" term="%22Cytoplasm%22">Cytoplasm</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Nerve impulses are propagated at nodes of Ranvier in the myclinated nerves of vertebrates. Internodal distances have been proposed to affect the velocity of nerve impulse conduction1; however, direct evidence is lacking, and the cellular mechanisms that might regulate the length of the myclinated segments are unknown. Ramón y Cajal described longitudinal and transverse bands of cytoplasm or trabeculae in intemodal Schwann cells and suggested that they had a nutritive function2. Here we show that internodal growth in wild-type nerves is precisely matched to nerve extension, but disruption of the cytoplasmic bands in Periaxin-null mice impairs Schwann cell elongation during nerve growth. By contrast, myelination proceeds normally. The capacity of wild-type and mutant Schwann cells to elongate is cell-autonomous, indicating that passive stretching can account for the lengthening of the internode during limb growth. As predicted on theoretical grounds, decreased internodal distances strikingly decrease conduction velocities and so affect motor function. We propose that microtubule-based transport in the longitudinal bands of Cajal permits internodal Schwann cells to lengthen in response to axonal growth, thus ensuring rapid nerve impulse transmission. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=14396914 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature02841 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 191 Subjects: – SubjectFull: Nerves Type: general – SubjectFull: Impulse (Psychology) Type: general – SubjectFull: Nodes of Ranvier Type: general – SubjectFull: Vertebrates Type: general – SubjectFull: Cells Type: general – SubjectFull: Cytoplasm Type: general Titles: – TitleFull: Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Court, Felipe A. – PersonEntity: Name: NameFull: Sherman, Diane L. – PersonEntity: Name: NameFull: Pratt, Thomas – PersonEntity: Name: NameFull: Garry, Emer M. – PersonEntity: Name: NameFull: Ribchester, Richard R. – PersonEntity: Name: NameFull: Cottreall, David F. – PersonEntity: Name: NameFull: Fleetwood-Walker, Susan M. – PersonEntity: Name: NameFull: Brophy, Peter J. IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 09 Text: 9/9/2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 431 – Type: issue Value: 7005 Titles: – TitleFull: Nature Type: main |
| ResultId | 1 |
