Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double‐blind, placebo‐controlled clinical trial.
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| Title: | Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double‐blind, placebo‐controlled clinical trial. |
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| Authors: | Momtazmanesh, Sara (AUTHOR), Amirimoghaddam‐Yazdi, Zeinab (AUTHOR), Moghaddam, Hossein Sanjari (AUTHOR), Mohammadi, Mohammad Reza (AUTHOR), Akhondzadeh, Shahin (AUTHOR) |
| Source: | Psychiatry & Clinical Neurosciences. Jul2020, Vol. 74 Issue 7, p398-405. 8p. 1 Diagram, 3 Charts, 2 Graphs. |
| Subjects: | Children with autism spectrum disorders, Sulforaphane, Autism spectrum disorders, Clinical trials, Treatment effectiveness |
| Abstract: | Aim: Irritability related to autism spectrum disorder (ASD) complicates the management of ASD patients at home and in clinical settings. In this randomized, double‐blind, placebo‐controlled clinical trial, we aimed to investigate the beneficial effects of adjuvant treatment with risperidone and sulforaphane in alleviating the irritability of children with ASD. Methods: Sixty drug‐free patients aged 4–12 years were randomly assigned to one of two groups receiving risperidone plus sulforaphane or placebo. Risperidone was started with a daily dose of 0.25 mg in patients weighing <20 kg and 0.5 mg in those weighing ≥20 kg and increased stepwise to reach a maximum of 1 mg (<20 kg), 2.5 mg (20–45 kg), and 3.5 mg (>45 kg). Sulforaphane was administered at a daily dose of 50 μmol (≤45 kg) or 100 μmol (>45 kg). The participants were assessed with the Aberrant Behavior Checklist – Community Edition at baseline and at Weeks 5 and 10. Results: Compared to the placebo group, ASD patients in the sulforaphane group showed greater improvements in Irritability score (primary outcome measure; P = 0.001) and Hyperactivity/Noncompliance score (secondary outcome measure; P = 0.015), and significant Time × Treatment effect for Irritability (P = 0.007) and Hyperactivity/Noncompliance (P = 0.008). However, no difference was seen in improvements in the other secondary measures: Lethargy/Social Interaction score, Stereotypic Behavior score, Inappropriate Speech score, and frequency of adverse events. Conclusion: Our results support the safety and efficacy of sulforaphane as an adjuvant to risperidone for improvement of irritability and hyperactivity symptoms in children with ASD. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 144355470 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double‐blind, placebo‐controlled clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Momtazmanesh%2C+Sara%22">Momtazmanesh, Sara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amirimoghaddam‐Yazdi%2C+Zeinab%22">Amirimoghaddam‐Yazdi, Zeinab</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moghaddam%2C+Hossein+Sanjari%22">Moghaddam, Hossein Sanjari</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mohammadi%2C+Mohammad+Reza%22">Mohammadi, Mohammad Reza</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akhondzadeh%2C+Shahin%22">Akhondzadeh, Shahin</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Jul2020, Vol. 74 Issue 7, p398-405. 8p. 1 Diagram, 3 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Children+with+autism+spectrum+disorders%22">Children with autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Sulforaphane%22">Sulforaphane</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aim: Irritability related to autism spectrum disorder (ASD) complicates the management of ASD patients at home and in clinical settings. In this randomized, double‐blind, placebo‐controlled clinical trial, we aimed to investigate the beneficial effects of adjuvant treatment with risperidone and sulforaphane in alleviating the irritability of children with ASD. Methods: Sixty drug‐free patients aged 4–12 years were randomly assigned to one of two groups receiving risperidone plus sulforaphane or placebo. Risperidone was started with a daily dose of 0.25 mg in patients weighing <20 kg and 0.5 mg in those weighing ≥20 kg and increased stepwise to reach a maximum of 1 mg (<20 kg), 2.5 mg (20–45 kg), and 3.5 mg (>45 kg). Sulforaphane was administered at a daily dose of 50 μmol (≤45 kg) or 100 μmol (>45 kg). The participants were assessed with the Aberrant Behavior Checklist – Community Edition at baseline and at Weeks 5 and 10. Results: Compared to the placebo group, ASD patients in the sulforaphane group showed greater improvements in Irritability score (primary outcome measure; P = 0.001) and Hyperactivity/Noncompliance score (secondary outcome measure; P = 0.015), and significant Time × Treatment effect for Irritability (P = 0.007) and Hyperactivity/Noncompliance (P = 0.008). However, no difference was seen in improvements in the other secondary measures: Lethargy/Social Interaction score, Stereotypic Behavior score, Inappropriate Speech score, and frequency of adverse events. Conclusion: Our results support the safety and efficacy of sulforaphane as an adjuvant to risperidone for improvement of irritability and hyperactivity symptoms in children with ASD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/pcn.13016 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 398 Subjects: – SubjectFull: Children with autism spectrum disorders Type: general – SubjectFull: Sulforaphane Type: general – SubjectFull: Autism spectrum disorders Type: general – SubjectFull: Clinical trials Type: general – SubjectFull: Treatment effectiveness Type: general Titles: – TitleFull: Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double‐blind, placebo‐controlled clinical trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Momtazmanesh, Sara – PersonEntity: Name: NameFull: Amirimoghaddam‐Yazdi, Zeinab – PersonEntity: Name: NameFull: Moghaddam, Hossein Sanjari – PersonEntity: Name: NameFull: Mohammadi, Mohammad Reza – PersonEntity: Name: NameFull: Akhondzadeh, Shahin IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 13231316 Numbering: – Type: volume Value: 74 – Type: issue Value: 7 Titles: – TitleFull: Psychiatry & Clinical Neurosciences Type: main |
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