Sex‐dependency of oestrogen‐induced structural synaptic plasticity: Inhibition of aromatase versus application of estradiol in rodents.
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| Title: | Sex‐dependency of oestrogen‐induced structural synaptic plasticity: Inhibition of aromatase versus application of estradiol in rodents. |
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| Authors: | Brandt, Nicola (AUTHOR), Rune, Gabriele M. (AUTHOR) |
| Source: | European Journal of Neuroscience. Jul2020, Vol. 52 Issue 1, p2548-2559. 12p. 1 Color Photograph, 2 Diagrams. |
| Subjects: | Neuroplasticity, Long-term potentiation, Sex (Biology), Rodents, Memory, Estradiol |
| Abstract: | Sex‐dependent differences in learning and memory formation in humans have been frequently shown. The mechanisms underlying the formation and retention of memories are assumed to involve synaptic plasticity in the hippocampus. Estradiol was shown to effect synaptic plasticity in the hippocampus of rodents. The effects after exogenous application of estradiol to animals frequently produce inconsistent results, in particular, if sex is not considered in the studies. Recently we provided evidence that locally synthesized estradiol plays an essential role on synaptic connectivity in the hippocampus of females but not of male mice. In females, inhibition of local estradiol synthesis leads to synapse loss, which results from impairment of long‐term potentiation and dephosphorylation of cofilin, and thereby the destabilization of postsynaptic dendritic spines. This sex‐dependency was also seen in the classical aromatase knock‐out mouse. Intriguingly, no differences between sexes have been found in a conditional forebrain‐specific aromatase knock‐out mouse. Altogether, the findings underscore the necessity of including 'Sex as a Biological Variable' in studies of sex steroid‐induced synaptic plasticity. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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