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A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity.

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Title: A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity.
Authors: Searchfield, G. D. (AUTHOR), Poppe, T. N. E. R. (AUTHOR), Durai, M. (AUTHOR), Jensen, M. (AUTHOR), Kennedy, M. A. (AUTHOR), Maggo, S. (AUTHOR), Miller, A. L. (AUTHOR), Park, J. (AUTHOR), Russell, B. R. (AUTHOR), Shekhawat, G. S. (AUTHOR), Spiegel, D. (AUTHOR), Sundram, F. (AUTHOR), Wise, K. (AUTHOR)
Source: International Journal of Neuroscience. Jul2020, Vol. 130 Issue 7, p671-682. 12p.
Subjects: Functional magnetic resonance imaging, Placebos, Psychoacoustics
Abstract: Background: This study was conducted to investigate the short-term behavioural and neurophysiological effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus perception. Methods: A double-blind randomized controlled cross-over design. Part 1. Behavioural measures of tinnitus following 30 mg MDMA or placebo administration (N = 5 participants) and Part 2. Behavioural measures of tinnitus and correlations between pairs of apriori regions of interest (ROI) using resting-state functional magnetic resonance imaging (rs-fMRI) before and after 70 mg of MDMA or placebo (N = 8 participants). Results: The results to MDMA were similar to placebo. For the 70 mg dose, there was a significant reduction after 4 h in annoyance and ignore ratings. RsMRI showed decreased connectivity compared with placebo administration between the left hippocampal, right hippocampal, left amygdala and right amygdala regions, and between the right posterior parahippocampal cortex and the left amygdala after two hours of 70 mg MDMA administration. Increased connectivity compared to placebo administration was found post MDMA between the right post-central gyrus and right posterior and superior temporal gyrus, and between the thalamus and frontoparietal network. Conclusions: Following 70 mg of MDMA two tinnitus rating scales significantly improved. There was, however, a placebo effect. Compared with placebo the rsMRI following the MDMA showed reductions in connectivity between the amygdala, hippocampus and parahippocampal gyrus. There is sufficient proof of concept to support future investigation of MDMA as a treatment for tinnitus. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity.
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  Data: <searchLink fieldCode="AR" term="%22Searchfield%2C+G%2E+D%2E%22">Searchfield, G. D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poppe%2C+T%2E+N%2E+E%2E+R%2E%22">Poppe, T. N. E. R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Durai%2C+M%2E%22">Durai, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jensen%2C+M%2E%22">Jensen, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kennedy%2C+M%2E+A%2E%22">Kennedy, M. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maggo%2C+S%2E%22">Maggo, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miller%2C+A%2E+L%2E%22">Miller, A. L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+J%2E%22">Park, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Russell%2C+B%2E+R%2E%22">Russell, B. R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shekhawat%2C+G%2E+S%2E%22">Shekhawat, G. S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spiegel%2C+D%2E%22">Spiegel, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sundram%2C+F%2E%22">Sundram, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wise%2C+K%2E%22">Wise, K.</searchLink> (AUTHOR)
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  Data: Background: This study was conducted to investigate the short-term behavioural and neurophysiological effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus perception. Methods: A double-blind randomized controlled cross-over design. Part 1. Behavioural measures of tinnitus following 30 mg MDMA or placebo administration (N = 5 participants) and Part 2. Behavioural measures of tinnitus and correlations between pairs of apriori regions of interest (ROI) using resting-state functional magnetic resonance imaging (rs-fMRI) before and after 70 mg of MDMA or placebo (N = 8 participants). Results: The results to MDMA were similar to placebo. For the 70 mg dose, there was a significant reduction after 4 h in annoyance and ignore ratings. RsMRI showed decreased connectivity compared with placebo administration between the left hippocampal, right hippocampal, left amygdala and right amygdala regions, and between the right posterior parahippocampal cortex and the left amygdala after two hours of 70 mg MDMA administration. Increased connectivity compared to placebo administration was found post MDMA between the right post-central gyrus and right posterior and superior temporal gyrus, and between the thalamus and frontoparietal network. Conclusions: Following 70 mg of MDMA two tinnitus rating scales significantly improved. There was, however, a placebo effect. Compared with placebo the rsMRI following the MDMA showed reductions in connectivity between the amygdala, hippocampus and parahippocampal gyrus. There is sufficient proof of concept to support future investigation of MDMA as a treatment for tinnitus. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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