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Individual risk and familial liability for suicide attempt and suicide in autism: a population-based study.

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Title: Individual risk and familial liability for suicide attempt and suicide in autism: a population-based study.
Authors: Hirvikoski, T., Boman, M., Chen, Q., D'Onofrio, B. M., Mittendorfer-Rutz, E., Lichtenstein, P., Bölte, S., Larsson, H.
Source: Psychological Medicine. Jul2020, Vol. 50 Issue 9, p1463-1474. 12p.
Subjects: Diagnosis of autism, Autism, Suicide risk factors, Confidence intervals, Reporting of diseases, Longitudinal method, Case studies, People with intellectual disabilities, Physicians, Risk assessment, Sex distribution, Suicidal behavior, Suicide, Comorbidity, Logistic regression analysis, Extended families, Psychosocial factors, Statistical models, Odds ratio
Geographic Terms: Sweden
Abstract: Background: Studies on the individual gender-specific risk and familial co-aggregation of suicidal behaviour in autism spectrum disorder (ASD) are lacking. Methods: We conducted a matched case-cohort study applying conditional logistic regression models on 54 168 individuals recorded in 1987–2013 with ASD in Swedish national registers: ASD without ID n = 43 570 (out of which n = 19035, 43.69% with ADHD); ASD + ID n = 10 598 (out of which n = 2894 individuals, 27.31% with ADHD), and 270 840 controls, as well as 347 155 relatives of individuals with ASD and 1 735 775 control relatives. Results: The risk for suicidal behaviours [reported as odds ratio OR (95% confidence interval CI)] was most increased in the ASD without ID group with comorbid ADHD [suicide attempt 7.25 (6.79–7.73); most severe attempts i.e. requiring inpatient stay 12.37 (11.33–13.52); suicide 13.09 (8.54–20.08)]. The risk was also increased in ASD + ID group [all suicide attempts 2.60 (2.31–2.92); inpatient only 3.45 (2.96–4.02); suicide 2.31 (1.16–4.57)]. Females with ASD without ID had generally higher risk for suicidal behaviours than males, while both genders had highest risk in the case of comorbid ADHD [females, suicide attempts 10.27 (9.27–11.37); inpatient only 13.42 (11.87–15.18); suicide 14.26 (6.03–33.72); males, suicide attempts 5.55 (5.10–6.05); inpatient only 11.33 (9.98–12.86); suicide 12.72 (7.77–20.82)]. Adjustment for psychiatric comorbidity attenuated the risk estimates. In comparison to controls, relatives of individuals with ASD also had an increased risk of suicidal behaviour. Conclusions: Clinicians treating patients with ASD should be vigilant for suicidal behaviour and consider treatment of psychiatric comorbidity. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Individual risk and familial liability for suicide attempt and suicide in autism: a population-based study.
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  Data: <searchLink fieldCode="AR" term="%22Hirvikoski%2C+T%2E%22">Hirvikoski, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Boman%2C+M%2E%22">Boman, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Q%2E%22">Chen, Q.</searchLink><br /><searchLink fieldCode="AR" term="%22D'Onofrio%2C+B%2E+M%2E%22">D'Onofrio, B. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mittendorfer-Rutz%2C+E%2E%22">Mittendorfer-Rutz, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Lichtenstein%2C+P%2E%22">Lichtenstein, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Bölte%2C+S%2E%22">Bölte, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Larsson%2C+H%2E%22">Larsson, H.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jul2020, Vol. 50 Issue 9, p1463-1474. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Diagnosis+of+autism%22">Diagnosis of autism</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Suicide+risk+factors%22">Suicide risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Reporting+of+diseases%22">Reporting of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Case+studies%22">Case studies</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+intellectual+disabilities%22">People with intellectual disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Physicians%22">Physicians</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Suicidal+behavior%22">Suicidal behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Suicide%22">Suicide</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Extended+families%22">Extended families</searchLink><br /><searchLink fieldCode="DE" term="%22Psychosocial+factors%22">Psychosocial factors</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+models%22">Statistical models</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Sweden%22">Sweden</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Studies on the individual gender-specific risk and familial co-aggregation of suicidal behaviour in autism spectrum disorder (ASD) are lacking. Methods: We conducted a matched case-cohort study applying conditional logistic regression models on 54 168 individuals recorded in 1987–2013 with ASD in Swedish national registers: ASD without ID n = 43 570 (out of which n = 19035, 43.69% with ADHD); ASD + ID n = 10 598 (out of which n = 2894 individuals, 27.31% with ADHD), and 270 840 controls, as well as 347 155 relatives of individuals with ASD and 1 735 775 control relatives. Results: The risk for suicidal behaviours [reported as odds ratio OR (95% confidence interval CI)] was most increased in the ASD without ID group with comorbid ADHD [suicide attempt 7.25 (6.79–7.73); most severe attempts i.e. requiring inpatient stay 12.37 (11.33–13.52); suicide 13.09 (8.54–20.08)]. The risk was also increased in ASD + ID group [all suicide attempts 2.60 (2.31–2.92); inpatient only 3.45 (2.96–4.02); suicide 2.31 (1.16–4.57)]. Females with ASD without ID had generally higher risk for suicidal behaviours than males, while both genders had highest risk in the case of comorbid ADHD [females, suicide attempts 10.27 (9.27–11.37); inpatient only 13.42 (11.87–15.18); suicide 14.26 (6.03–33.72); males, suicide attempts 5.55 (5.10–6.05); inpatient only 11.33 (9.98–12.86); suicide 12.72 (7.77–20.82)]. Adjustment for psychiatric comorbidity attenuated the risk estimates. In comparison to controls, relatives of individuals with ASD also had an increased risk of suicidal behaviour. Conclusions: Clinicians treating patients with ASD should be vigilant for suicidal behaviour and consider treatment of psychiatric comorbidity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=144772219
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    Identifiers:
      – Type: doi
        Value: 10.1017/S0033291719001405
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 1463
    Subjects:
      – SubjectFull: Diagnosis of autism
        Type: general
      – SubjectFull: Autism
        Type: general
      – SubjectFull: Suicide risk factors
        Type: general
      – SubjectFull: Confidence intervals
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      – SubjectFull: Reporting of diseases
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Case studies
        Type: general
      – SubjectFull: People with intellectual disabilities
        Type: general
      – SubjectFull: Physicians
        Type: general
      – SubjectFull: Risk assessment
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      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Suicidal behavior
        Type: general
      – SubjectFull: Suicide
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Logistic regression analysis
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      – SubjectFull: Extended families
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      – SubjectFull: Psychosocial factors
        Type: general
      – SubjectFull: Statistical models
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      – SubjectFull: Odds ratio
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      – SubjectFull: Sweden
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      – TitleFull: Individual risk and familial liability for suicide attempt and suicide in autism: a population-based study.
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              Text: Jul2020
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