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Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types.

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Title: Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types.
Authors: Laszlovszky, Tamás (AUTHOR), Schlingloff, Dániel (AUTHOR), Hegedüs, Panna (AUTHOR), Freund, Tamás F. (AUTHOR), Gulyás, Attila (AUTHOR), Kepecs, Adam (AUTHOR), Hangya, Balázs (AUTHOR)
Source: Nature Neuroscience. Aug2020, Vol. 23 Issue 8, p992-1003. 12p. 7 Color Photographs, 10 Graphs.
Abstract: Basal forebrain cholinergic neurons (BFCNs) modulate synaptic plasticity, cortical processing, brain states and oscillations. However, whether distinct types of BFCNs support different functions remains unclear. Therefore, we recorded BFCNs in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties. We identified two distinct types of BFCNs that differ in their firing modes, synchronization properties and behavioral correlates. Bursting cholinergic neurons (Burst-BFCNs) fired synchronously, phase-locked to cortical theta activity and fired precisely timed bursts after reward and punishment. Regular-firing cholinergic neurons (Reg-BFCNs) were found predominantly in the posterior basal forebrain, displayed strong theta rhythmicity and responded with precise single spikes after behavioral outcomes. In an auditory detection task, synchronization of Burst-BFCNs to the auditory cortex predicted the timing of behavioral responses, whereas tone-evoked cortical coupling of Reg-BFCNs predicted correct detections. We propose that differential recruitment of two basal forebrain cholinergic neuron types generates behavior-specific cortical activation. Laszlovszky et al. demonstrate the presence of two types of cholinergic neurons that differ in cellular physiology, coupling with cortical oscillations, synchrony within each group, behavior performance correlates and anatomical distribution. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types.
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  Data: <searchLink fieldCode="AR" term="%22Laszlovszky%2C+Tamás%22">Laszlovszky, Tamás</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schlingloff%2C+Dániel%22">Schlingloff, Dániel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hegedüs%2C+Panna%22">Hegedüs, Panna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Freund%2C+Tamás+F%2E%22">Freund, Tamás F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gulyás%2C+Attila%22">Gulyás, Attila</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kepecs%2C+Adam%22">Kepecs, Adam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hangya%2C+Balázs%22">Hangya, Balázs</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Aug2020, Vol. 23 Issue 8, p992-1003. 12p. 7 Color Photographs, 10 Graphs.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Basal forebrain cholinergic neurons (BFCNs) modulate synaptic plasticity, cortical processing, brain states and oscillations. However, whether distinct types of BFCNs support different functions remains unclear. Therefore, we recorded BFCNs in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties. We identified two distinct types of BFCNs that differ in their firing modes, synchronization properties and behavioral correlates. Bursting cholinergic neurons (Burst-BFCNs) fired synchronously, phase-locked to cortical theta activity and fired precisely timed bursts after reward and punishment. Regular-firing cholinergic neurons (Reg-BFCNs) were found predominantly in the posterior basal forebrain, displayed strong theta rhythmicity and responded with precise single spikes after behavioral outcomes. In an auditory detection task, synchronization of Burst-BFCNs to the auditory cortex predicted the timing of behavioral responses, whereas tone-evoked cortical coupling of Reg-BFCNs predicted correct detections. We propose that differential recruitment of two basal forebrain cholinergic neuron types generates behavior-specific cortical activation. Laszlovszky et al. demonstrate the presence of two types of cholinergic neurons that differ in cellular physiology, coupling with cortical oscillations, synchrony within each group, behavior performance correlates and anatomical distribution. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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