View in EDS

Does Interleukin-6 Genotype Influence Cerebral Injury or Developmental Progress After Preterm Birth?

Saved in:
Bibliographic Details
Title: Does Interleukin-6 Genotype Influence Cerebral Injury or Developmental Progress After Preterm Birth?
Authors: Harding, David R., Dhamrait, Sukbhir, Whitelaw, Andrew, Humphries, Steve E., Marlow, Neil, Montgomery, Hugh E.
Source: Pediatrics. Oct2004, Vol. 114 Issue 4, p941-947. 7p. 3 Charts.
Subjects: Interleukin-6, Genetic polymorphisms, Cerebral palsy, Brain damage, Premature infants
Abstract: Objective. The severity of the proinflammatory response may determine outcome in the critically ill. Genetic variation in the promoter region of the gene encoding the proinflammatory cytokine interleukin- 6 (IL-6; -174 CC genotype) may encode enhanced production of IL-6. Our objective was to determine whether the CC genotype is associated with worse early illness severity, neurologic injury, and lower developmental scores among surviving preterm children. Methods. Genotype was determined from dried blood spots that were taken for neonatal screening tests 7 days or more after birth; outcome was independently assessed as part of a longitudinal study of children of >32 weeks' gestational age. Results. CC genotype was associated with worse intensive care indices. Significant hemorrhagic brain injuries occurred in 5 (19%) of 27 children with CC genotype compared with 7 (6%) of 121 children with GC or GG genotype, and images consistent with white matter damage (ventriculomegaly or cystic periventricular leukomalacia) occurred in 9 (26%) of CC patients compared with 9 (7%) in GC/GG children. Disability occurred significantly more often in CC children: 8 (31%) compared with 16 (13%). A similar trend was also noted in children with cerebral palsy (15% compared with 7%, respectively). Developmental, cognitive, and motor scores at 2 years and 5.5 years were independent of genotype among children with or without disability. Conclusions. In a population of surviving children who were born at >32 weeks' gestational age, variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 14487661
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Does Interleukin-6 Genotype Influence Cerebral Injury or Developmental Progress After Preterm Birth?
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Harding%2C+David+R%2E%22">Harding, David R.</searchLink><br /><searchLink fieldCode="AR" term="%22Dhamrait%2C+Sukbhir%22">Dhamrait, Sukbhir</searchLink><br /><searchLink fieldCode="AR" term="%22Whitelaw%2C+Andrew%22">Whitelaw, Andrew</searchLink><br /><searchLink fieldCode="AR" term="%22Humphries%2C+Steve+E%2E%22">Humphries, Steve E.</searchLink><br /><searchLink fieldCode="AR" term="%22Marlow%2C+Neil%22">Marlow, Neil</searchLink><br /><searchLink fieldCode="AR" term="%22Montgomery%2C+Hugh+E%2E%22">Montgomery, Hugh E.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Oct2004, Vol. 114 Issue 4, p941-947. 7p. 3 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Interleukin-6%22">Interleukin-6</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+palsy%22">Cerebral palsy</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+damage%22">Brain damage</searchLink><br /><searchLink fieldCode="DE" term="%22Premature+infants%22">Premature infants</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective. The severity of the proinflammatory response may determine outcome in the critically ill. Genetic variation in the promoter region of the gene encoding the proinflammatory cytokine interleukin- 6 (IL-6; -174 CC genotype) may encode enhanced production of IL-6. Our objective was to determine whether the CC genotype is associated with worse early illness severity, neurologic injury, and lower developmental scores among surviving preterm children. Methods. Genotype was determined from dried blood spots that were taken for neonatal screening tests 7 days or more after birth; outcome was independently assessed as part of a longitudinal study of children of >32 weeks' gestational age. Results. CC genotype was associated with worse intensive care indices. Significant hemorrhagic brain injuries occurred in 5 (19%) of 27 children with CC genotype compared with 7 (6%) of 121 children with GC or GG genotype, and images consistent with white matter damage (ventriculomegaly or cystic periventricular leukomalacia) occurred in 9 (26%) of CC patients compared with 9 (7%) in GC/GG children. Disability occurred significantly more often in CC children: 8 (31%) compared with 16 (13%). A similar trend was also noted in children with cerebral palsy (15% compared with 7%, respectively). Developmental, cognitive, and motor scores at 2 years and 5.5 years were independent of genotype among children with or without disability. Conclusions. In a population of surviving children who were born at >32 weeks' gestational age, variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=14487661
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1542/peds.2003-0494-F
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 941
    Subjects:
      – SubjectFull: Interleukin-6
        Type: general
      – SubjectFull: Genetic polymorphisms
        Type: general
      – SubjectFull: Cerebral palsy
        Type: general
      – SubjectFull: Brain damage
        Type: general
      – SubjectFull: Premature infants
        Type: general
    Titles:
      – TitleFull: Does Interleukin-6 Genotype Influence Cerebral Injury or Developmental Progress After Preterm Birth?
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Harding, David R.
      – PersonEntity:
          Name:
            NameFull: Dhamrait, Sukbhir
      – PersonEntity:
          Name:
            NameFull: Whitelaw, Andrew
      – PersonEntity:
          Name:
            NameFull: Humphries, Steve E.
      – PersonEntity:
          Name:
            NameFull: Marlow, Neil
      – PersonEntity:
          Name:
            NameFull: Montgomery, Hugh E.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: Oct2004
              Type: published
              Y: 2004
          Identifiers:
            – Type: issn-print
              Value: 00314005
          Numbering:
            – Type: volume
              Value: 114
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Pediatrics
              Type: main
ResultId 1