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Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations.

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Title: Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations.
Authors: Sonmez, A. Irem (AUTHOR), Almorsy, Ammar (AUTHOR), Ramsey, Laura B. (AUTHOR), Strawn, Jeffrey R. (AUTHOR), Croarkin, Paul E. (AUTHOR)
Source: Depression & Anxiety (1091-4269). Aug2020, Vol. 37 Issue 8, p747-759. 13p. 2 Diagrams, 1 Chart.
Subjects: Generalized anxiety disorder, Anxiety treatment, GABA, Drug side effects, Riluzole
Abstract: Background: Pediatric anxiety disorders such as generalized anxiety disorder (GAD) are common, impairing, and often undertreated. Moreover, many youth do not respond to standard, evidence-based psychosocial or psychopharmacologic treatment. An increased understanding of the gamma-aminobutyric acid (GABA) and glutamate neurotransmitter systems has created opportunities for novel intervention development for pediatric GAD.Methods: This narrative review examines potential candidates for pediatric GAD: eszopiclone, riluzole, eglumegad (LY354740), pimavanserin, agomelatine.Results: The pharmacology, preclinical data, clinical trial findings and known side effects of eszopiclone, riluzole, eglumegad (LY354740), pimavanserin, agomelatine, are reviewed, particularly with regard to their potential therapeutic relevance to pediatric GAD.Conclusion: Notwithstanding numerous challenges, some of these agents represent potential candidate drugs for pediatric GAD. Further treatment development studies of agomelatine, eszopiclone, pimavanserin and riluzole for pediatric GAD also have the prospect of informing the understanding of GABAergic and glutamatergic function across development. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations.
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  Data: <searchLink fieldCode="AR" term="%22Sonmez%2C+A%2E+Irem%22">Sonmez, A. Irem</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Almorsy%2C+Ammar%22">Almorsy, Ammar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramsey%2C+Laura+B%2E%22">Ramsey, Laura B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Strawn%2C+Jeffrey+R%2E%22">Strawn, Jeffrey R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Croarkin%2C+Paul+E%2E%22">Croarkin, Paul E.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. Aug2020, Vol. 37 Issue 8, p747-759. 13p. 2 Diagrams, 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Generalized+anxiety+disorder%22">Generalized anxiety disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+treatment%22">Anxiety treatment</searchLink><br /><searchLink fieldCode="DE" term="%22GABA%22">GABA</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Riluzole%22">Riluzole</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>Pediatric anxiety disorders such as generalized anxiety disorder (GAD) are common, impairing, and often undertreated. Moreover, many youth do not respond to standard, evidence-based psychosocial or psychopharmacologic treatment. An increased understanding of the gamma-aminobutyric acid (GABA) and glutamate neurotransmitter systems has created opportunities for novel intervention development for pediatric GAD.<bold>Methods: </bold>This narrative review examines potential candidates for pediatric GAD: eszopiclone, riluzole, eglumegad (LY354740), pimavanserin, agomelatine.<bold>Results: </bold>The pharmacology, preclinical data, clinical trial findings and known side effects of eszopiclone, riluzole, eglumegad (LY354740), pimavanserin, agomelatine, are reviewed, particularly with regard to their potential therapeutic relevance to pediatric GAD.<bold>Conclusion: </bold>Notwithstanding numerous challenges, some of these agents represent potential candidate drugs for pediatric GAD. Further treatment development studies of agomelatine, eszopiclone, pimavanserin and riluzole for pediatric GAD also have the prospect of informing the understanding of GABAergic and glutamatergic function across development. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Aug2020
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